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- W4285698108 abstract "Abstract Background Archaea are the least-studied members of the gut-dwelling autochthonous microbiota. Few studies have reported the exclusive dominance of methanogens in the archaeal microbiome (archaeome) of the human gut, although information regarding the diversity and abundance of other archaeal phylotypes is limited. Results We surveyed the archaeome in the faecal samples collected from 897 normal East Asian subjects living in South Korea. In total, 42.47% faecal samples were positive for archaeal colonization, which were subsequently subjected to archaeal 16S rRNA gene deep sequencing and abundance estimation. The mean archaeal abundance was 9.89 ± 4.48% of the total bacterial and archaeal abundance. We observed extensive colonization of haloarchaea (95.53%) in the Korean gut, with 9.63% mean relative abundance in archaeal communities. Haloarchaea were relatively more abundant than methanogens in certain samples. The presence of haloarchaea was also verified by fluorescence in situ hybridization analysis. Owing to large inter-individual variations, we categorized the human gut archaeome into four archaeal enterotypes. Conclusions The study demonstrated that the human gut archaeome is indigenous, responsive, and functional, expanding our understanding of the archaeal signature in the gut of normal healthy individuals." @default.
- W4285698108 created "2022-07-18" @default.
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- W4285698108 date "2020-03-17" @default.
- W4285698108 modified "2023-10-16" @default.
- W4285698108 title "The human gut archaeome: identification of diverse haloarchaea in Korean subjects" @default.
- W4285698108 doi "https://doi.org/10.21203/rs.3.rs-17518/v1" @default.
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