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- W4285702922 abstract "Abstract Background Several studies have shown a substantial impact of Rotavirus (RV) vaccination on the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of most impact studies could be confused by a dynamic and complex space-time process. Therefore, there is a need to analyse the impact of RV vaccination on RV and AGE hospitalisations in a space-time framework to detect geographical-time patterns while avoiding the potential confusion caused by population inequalities in the impact estimations. Methods A retrospective population-based study using real-world data from the Valencia Region was performed among children aged less than 3 years old in the period 2005-2016. A Bayesian spatio-temporal model was constructed to analyse RV and AGE hospitalisations and to estimate the vaccination impact measured in averted hospitalisations. Results We found important spatio-temporal patterns in RV and AGE hospitalisations, RV vaccination coverage and in their associated adverted hospitalisations. Overall, ~1866 hospital admissions for RV were averted by RV vaccination during 2007–2016. Despite the low-medium vaccine coverage (~50%) in 2015-2016, relevant 36% and 20% reductions were estimated in RV and AGE hospitalisations respectively. Conclusions The introduction of the RV vaccines has substantially reduced the number of RV hospitalisations, averting ~1866 admissions during 2007-2016 which were space and time dependent. This study improves the methodologies commonly used to estimate the RV vaccine impact and their interpretation." @default.
- W4285702922 created "2022-07-18" @default.
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- W4285702922 date "2020-03-03" @default.
- W4285702922 modified "2023-10-06" @default.
- W4285702922 title "Spatio-temporal impact of self-financed Rotavirus vaccination on Rotavirus and acute gastroenteritis hospitalisations in the Valencia Region, Spain" @default.
- W4285702922 doi "https://doi.org/10.21203/rs.3.rs-15736/v1" @default.
- W4285702922 hasPublicationYear "2020" @default.
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