Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285702985> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4285702985 endingPage "487" @default.
- W4285702985 startingPage "479" @default.
- W4285702985 abstract "A self-nano emulsifying drug delivery system (SNEDDS) has been explored to improve poorly watersoluble drug clopidogrel’s solubility and dissolution rate. Different formulations were prepared using oil, surfactant, and co-surfactant in varying ratios. From the ternary phase diagram resultant formulations were investigated for clarity, phase separation, drug content, % transmittance, globule size, freeze-thaw, in vitro dissolution studies, particle size analysis, and zeta potential. Based on particle size, zeta potential and dissolution profile, and other studies, F6 was the best formulation of clopidogrel SNEDDS. The particle size of the optimized SNEDDS formulation was found to be 5.2 nm, and zeta potential was found to be -29 mV which complies with the requirement of the zeta potential for stability. The % release from optimized SNEDDS formulation F6 was highest (98.93%) and faster than other SNEDDS formulations and pure drug substance (32%), indicating the influence of droplet size on the drug dissolution rate. FTIR data revealed no physicochemical interaction between drug and excipients. In vivo bioavailability studies were carried out on the optimized formulation (F6), mean time to attain peak drug concentration (Tmax) was 0.5 ± 0.53 and 1.5 ± 0.72 minutes for the optimized and pure drug, respectively, while means maximum drug concentration (Cmax) was 6.77 ± 1.73 ng/mL and 2.10 ± 0.39 ng/mL respectively. AUC0-α and AUC0-t for the optimized formulation were significantly higher (p is less than0.05) 20.5 ± 2.48 ng.h/mL than the pure drug 6.34 ± 1.73 ng h/mL, respectively. Thus, the results indicate clopidogrel with SNEDDS formulation may be used to improve solubility and dissolution rate for the effective management of heart disease." @default.
- W4285702985 created "2022-07-18" @default.
- W4285702985 creator A5033022937 @default.
- W4285702985 creator A5092754068 @default.
- W4285702985 date "2020-03-03" @default.
- W4285702985 modified "2023-09-26" @default.
- W4285702985 title "Formulation and In-vivo Studies of Clopidogrel by Self-nanoemulsifying Drug Delivery System" @default.
- W4285702985 doi "https://doi.org/10.25004/ijpsdr.2021.130504" @default.
- W4285702985 hasPublicationYear "2020" @default.
- W4285702985 type Work @default.
- W4285702985 citedByCount "0" @default.
- W4285702985 crossrefType "journal-article" @default.
- W4285702985 hasAuthorship W4285702985A5033022937 @default.
- W4285702985 hasAuthorship W4285702985A5092754068 @default.
- W4285702985 hasBestOaLocation W42857029851 @default.
- W4285702985 hasConcept C14029885 @default.
- W4285702985 hasConcept C147789679 @default.
- W4285702985 hasConcept C155574463 @default.
- W4285702985 hasConcept C155672457 @default.
- W4285702985 hasConcept C171250308 @default.
- W4285702985 hasConcept C178790620 @default.
- W4285702985 hasConcept C181389837 @default.
- W4285702985 hasConcept C185592680 @default.
- W4285702985 hasConcept C187530423 @default.
- W4285702985 hasConcept C192562407 @default.
- W4285702985 hasConcept C22979827 @default.
- W4285702985 hasConcept C2779820397 @default.
- W4285702985 hasConcept C2780035454 @default.
- W4285702985 hasConcept C2781430271 @default.
- W4285702985 hasConcept C43617362 @default.
- W4285702985 hasConcept C55493867 @default.
- W4285702985 hasConcept C58226133 @default.
- W4285702985 hasConcept C71924100 @default.
- W4285702985 hasConcept C86181022 @default.
- W4285702985 hasConcept C88380143 @default.
- W4285702985 hasConcept C98274493 @default.
- W4285702985 hasConceptScore W4285702985C14029885 @default.
- W4285702985 hasConceptScore W4285702985C147789679 @default.
- W4285702985 hasConceptScore W4285702985C155574463 @default.
- W4285702985 hasConceptScore W4285702985C155672457 @default.
- W4285702985 hasConceptScore W4285702985C171250308 @default.
- W4285702985 hasConceptScore W4285702985C178790620 @default.
- W4285702985 hasConceptScore W4285702985C181389837 @default.
- W4285702985 hasConceptScore W4285702985C185592680 @default.
- W4285702985 hasConceptScore W4285702985C187530423 @default.
- W4285702985 hasConceptScore W4285702985C192562407 @default.
- W4285702985 hasConceptScore W4285702985C22979827 @default.
- W4285702985 hasConceptScore W4285702985C2779820397 @default.
- W4285702985 hasConceptScore W4285702985C2780035454 @default.
- W4285702985 hasConceptScore W4285702985C2781430271 @default.
- W4285702985 hasConceptScore W4285702985C43617362 @default.
- W4285702985 hasConceptScore W4285702985C55493867 @default.
- W4285702985 hasConceptScore W4285702985C58226133 @default.
- W4285702985 hasConceptScore W4285702985C71924100 @default.
- W4285702985 hasConceptScore W4285702985C86181022 @default.
- W4285702985 hasConceptScore W4285702985C88380143 @default.
- W4285702985 hasConceptScore W4285702985C98274493 @default.
- W4285702985 hasIssue "05" @default.
- W4285702985 hasLocation W42857029851 @default.
- W4285702985 hasOpenAccess W4285702985 @default.
- W4285702985 hasPrimaryLocation W42857029851 @default.
- W4285702985 hasRelatedWork W1972121686 @default.
- W4285702985 hasRelatedWork W2043446470 @default.
- W4285702985 hasRelatedWork W2083034643 @default.
- W4285702985 hasRelatedWork W2086623451 @default.
- W4285702985 hasRelatedWork W2096309345 @default.
- W4285702985 hasRelatedWork W2317645922 @default.
- W4285702985 hasRelatedWork W2325393554 @default.
- W4285702985 hasRelatedWork W2592924892 @default.
- W4285702985 hasRelatedWork W875949149 @default.
- W4285702985 hasRelatedWork W3089060975 @default.
- W4285702985 hasVolume "13" @default.
- W4285702985 isParatext "false" @default.
- W4285702985 isRetracted "false" @default.
- W4285702985 workType "article" @default.