Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285703022> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4285703022 abstract "Abstract Disturbed sleep is associated with cognitive decline in Alzheimer’s disease (AD) patients. The progressive sequence of how neurodegeneration affects aspects of sleep architecture in conjunction with behavioural changes is not well understood. We investigated changes in sleep architecture, spectral power and circadian rhythmicity in the tet-off rTg4510 mouse overexpressing human P301L tau within the same subject over time. Doxycycline-induced transgene-suppressed rTg4510 mice, tTa carriers and wild-type mice were used as comparators. Using EEG electrodes, spectral power and sleep stages were measured from within the home cage environment. In addition, locomotor activity and performance during a T-maze task were measured. Spectral power, primarily in the NREM delta band, showed a time-dependent decrease in rTg4510 mice compared to all other groups. After the initial changes in spectral power, wake during the dark period increased whereas NREM and number of REM sleep bouts decreased in rTg4510 compared to wild-type mice. Home cage locomotor activity significantly increased in rTg4510 compared to wild-type mice by 40 weeks of age. Peak-to-peak circadian rhythm amplitude and performance in the T-maze was impaired throughout the experiment independent of time. At 46 weeks brain histopathological changes were measured in all animals demonstrating significant degeneration in hippocampus and cortex, and protection with doxycycline. Pathology significantly correlated with sleep outcomes, in addition to locomotor and cognitive measures. In conclusion, we show that reduced EEG slow wave activity precedes reductions in sleep and home-cage locomotor activity in a mouse model of tauopathy. The data shows increasing mutant tau changes sleep architecture, EEG properties, behavior and cognition; which suggest tau related effects on sleep architecture in AD patients." @default.
- W4285703022 created "2022-07-18" @default.
- W4285703022 creator A5000321046 @default.
- W4285703022 creator A5004375021 @default.
- W4285703022 creator A5034067504 @default.
- W4285703022 creator A5035900980 @default.
- W4285703022 creator A5042909017 @default.
- W4285703022 creator A5048701762 @default.
- W4285703022 creator A5049968178 @default.
- W4285703022 creator A5056880508 @default.
- W4285703022 creator A5059871245 @default.
- W4285703022 date "2020-03-03" @default.
- W4285703022 modified "2023-09-28" @default.
- W4285703022 title "Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration." @default.
- W4285703022 doi "https://doi.org/10.21203/rs.3.rs-15862/v1" @default.
- W4285703022 hasPublicationYear "2020" @default.
- W4285703022 type Work @default.
- W4285703022 citedByCount "0" @default.
- W4285703022 crossrefType "posted-content" @default.
- W4285703022 hasAuthorship W4285703022A5000321046 @default.
- W4285703022 hasAuthorship W4285703022A5004375021 @default.
- W4285703022 hasAuthorship W4285703022A5034067504 @default.
- W4285703022 hasAuthorship W4285703022A5035900980 @default.
- W4285703022 hasAuthorship W4285703022A5042909017 @default.
- W4285703022 hasAuthorship W4285703022A5048701762 @default.
- W4285703022 hasAuthorship W4285703022A5049968178 @default.
- W4285703022 hasAuthorship W4285703022A5056880508 @default.
- W4285703022 hasAuthorship W4285703022A5059871245 @default.
- W4285703022 hasBestOaLocation W42857030221 @default.
- W4285703022 hasConcept C111919701 @default.
- W4285703022 hasConcept C121332964 @default.
- W4285703022 hasConcept C121446783 @default.
- W4285703022 hasConcept C126322002 @default.
- W4285703022 hasConcept C134018914 @default.
- W4285703022 hasConcept C15744967 @default.
- W4285703022 hasConcept C169760540 @default.
- W4285703022 hasConcept C20566671 @default.
- W4285703022 hasConcept C24890656 @default.
- W4285703022 hasConcept C2775841894 @default.
- W4285703022 hasConcept C2776925932 @default.
- W4285703022 hasConcept C2777739294 @default.
- W4285703022 hasConcept C2778329153 @default.
- W4285703022 hasConcept C2779134260 @default.
- W4285703022 hasConcept C2781161787 @default.
- W4285703022 hasConcept C2781291010 @default.
- W4285703022 hasConcept C41008148 @default.
- W4285703022 hasConcept C522805319 @default.
- W4285703022 hasConcept C71924100 @default.
- W4285703022 hasConceptScore W4285703022C111919701 @default.
- W4285703022 hasConceptScore W4285703022C121332964 @default.
- W4285703022 hasConceptScore W4285703022C121446783 @default.
- W4285703022 hasConceptScore W4285703022C126322002 @default.
- W4285703022 hasConceptScore W4285703022C134018914 @default.
- W4285703022 hasConceptScore W4285703022C15744967 @default.
- W4285703022 hasConceptScore W4285703022C169760540 @default.
- W4285703022 hasConceptScore W4285703022C20566671 @default.
- W4285703022 hasConceptScore W4285703022C24890656 @default.
- W4285703022 hasConceptScore W4285703022C2775841894 @default.
- W4285703022 hasConceptScore W4285703022C2776925932 @default.
- W4285703022 hasConceptScore W4285703022C2777739294 @default.
- W4285703022 hasConceptScore W4285703022C2778329153 @default.
- W4285703022 hasConceptScore W4285703022C2779134260 @default.
- W4285703022 hasConceptScore W4285703022C2781161787 @default.
- W4285703022 hasConceptScore W4285703022C2781291010 @default.
- W4285703022 hasConceptScore W4285703022C41008148 @default.
- W4285703022 hasConceptScore W4285703022C522805319 @default.
- W4285703022 hasConceptScore W4285703022C71924100 @default.
- W4285703022 hasLocation W42857030221 @default.
- W4285703022 hasLocation W42857030222 @default.
- W4285703022 hasLocation W42857030223 @default.
- W4285703022 hasOpenAccess W4285703022 @default.
- W4285703022 hasPrimaryLocation W42857030221 @default.
- W4285703022 hasRelatedWork W1600658415 @default.
- W4285703022 hasRelatedWork W189532250 @default.
- W4285703022 hasRelatedWork W1980943192 @default.
- W4285703022 hasRelatedWork W2000750607 @default.
- W4285703022 hasRelatedWork W2023414805 @default.
- W4285703022 hasRelatedWork W2181502492 @default.
- W4285703022 hasRelatedWork W2372236271 @default.
- W4285703022 hasRelatedWork W2378138679 @default.
- W4285703022 hasRelatedWork W2505914565 @default.
- W4285703022 hasRelatedWork W3205383111 @default.
- W4285703022 isParatext "false" @default.
- W4285703022 isRetracted "false" @default.
- W4285703022 workType "article" @default.