Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285729803> ?p ?o ?g. }
- W4285729803 abstract "Abstract We explore current ideas around the representation of a protein as an amorphous material, in turn represented by an abstract graph 𝒢 with edges weighted by elastic stiffnesses. By embedding this graph in physical space, we can map every graph to a spectrum of conformational fluctuations and responses (as a result of say, ligand-binding). This sets up a “genotype-phenotype” map, which we use to evolve the amorphous material to select for fitness. Using this, we study the emergence of allosteric interaction, hinge joint, crack formation and a slide bolt in functional proteins such as Adenylate kinase, HSP90, Calmodulin and GPCR proteins. We find that these emergent features are associated with specific geometries and mode spectra of floppy or liquid-like regions. Our analysis provides insight into understanding the architectural demands on a protein that enable a prescribed function and its stability to mutations." @default.
- W4285729803 created "2022-07-18" @default.
- W4285729803 creator A5010558645 @default.
- W4285729803 creator A5012972121 @default.
- W4285729803 creator A5028628058 @default.
- W4285729803 creator A5062853417 @default.
- W4285729803 date "2022-07-18" @default.
- W4285729803 modified "2023-09-23" @default.
- W4285729803 title "Protein as evolvable functionally-constrained amorphous matter" @default.
- W4285729803 cites W1576403707 @default.
- W4285729803 cites W1969460352 @default.
- W4285729803 cites W1969644422 @default.
- W4285729803 cites W1974093948 @default.
- W4285729803 cites W1989161865 @default.
- W4285729803 cites W1998093640 @default.
- W4285729803 cites W2003180932 @default.
- W4285729803 cites W2004967763 @default.
- W4285729803 cites W2005392755 @default.
- W4285729803 cites W2007304949 @default.
- W4285729803 cites W2007436440 @default.
- W4285729803 cites W2021664957 @default.
- W4285729803 cites W2038441129 @default.
- W4285729803 cites W2039258749 @default.
- W4285729803 cites W2045777307 @default.
- W4285729803 cites W2056479429 @default.
- W4285729803 cites W2069187446 @default.
- W4285729803 cites W2072699715 @default.
- W4285729803 cites W2082028745 @default.
- W4285729803 cites W2083654158 @default.
- W4285729803 cites W2094795801 @default.
- W4285729803 cites W2096929343 @default.
- W4285729803 cites W2097294533 @default.
- W4285729803 cites W2104477830 @default.
- W4285729803 cites W2106777560 @default.
- W4285729803 cites W2107238748 @default.
- W4285729803 cites W2145897869 @default.
- W4285729803 cites W2151457629 @default.
- W4285729803 cites W2172021704 @default.
- W4285729803 cites W2485975781 @default.
- W4285729803 cites W2519253539 @default.
- W4285729803 cites W2577732298 @default.
- W4285729803 cites W2614802632 @default.
- W4285729803 cites W2744309759 @default.
- W4285729803 cites W2777807685 @default.
- W4285729803 cites W2798859743 @default.
- W4285729803 cites W2809303314 @default.
- W4285729803 cites W2950773610 @default.
- W4285729803 cites W2962790996 @default.
- W4285729803 cites W2964643360 @default.
- W4285729803 cites W2997054914 @default.
- W4285729803 cites W3102870834 @default.
- W4285729803 cites W3110573705 @default.
- W4285729803 cites W3135516789 @default.
- W4285729803 cites W4214901844 @default.
- W4285729803 cites W4239833133 @default.
- W4285729803 doi "https://doi.org/10.1101/2022.07.17.500335" @default.
- W4285729803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36503910" @default.
- W4285729803 hasPublicationYear "2022" @default.
- W4285729803 type Work @default.
- W4285729803 citedByCount "0" @default.
- W4285729803 crossrefType "posted-content" @default.
- W4285729803 hasAuthorship W4285729803A5010558645 @default.
- W4285729803 hasAuthorship W4285729803A5012972121 @default.
- W4285729803 hasAuthorship W4285729803A5028628058 @default.
- W4285729803 hasAuthorship W4285729803A5062853417 @default.
- W4285729803 hasBestOaLocation W42857298031 @default.
- W4285729803 hasConcept C127413603 @default.
- W4285729803 hasConcept C132525143 @default.
- W4285729803 hasConcept C154945302 @default.
- W4285729803 hasConcept C166342909 @default.
- W4285729803 hasConcept C170493617 @default.
- W4285729803 hasConcept C17744445 @default.
- W4285729803 hasConcept C185592680 @default.
- W4285729803 hasConcept C199539241 @default.
- W4285729803 hasConcept C2776359362 @default.
- W4285729803 hasConcept C41008148 @default.
- W4285729803 hasConcept C41608201 @default.
- W4285729803 hasConcept C44000306 @default.
- W4285729803 hasConcept C54355233 @default.
- W4285729803 hasConcept C56052488 @default.
- W4285729803 hasConcept C66938386 @default.
- W4285729803 hasConcept C70721500 @default.
- W4285729803 hasConcept C78458016 @default.
- W4285729803 hasConcept C8010536 @default.
- W4285729803 hasConcept C80444323 @default.
- W4285729803 hasConcept C86803240 @default.
- W4285729803 hasConcept C94625758 @default.
- W4285729803 hasConceptScore W4285729803C127413603 @default.
- W4285729803 hasConceptScore W4285729803C132525143 @default.
- W4285729803 hasConceptScore W4285729803C154945302 @default.
- W4285729803 hasConceptScore W4285729803C166342909 @default.
- W4285729803 hasConceptScore W4285729803C170493617 @default.
- W4285729803 hasConceptScore W4285729803C17744445 @default.
- W4285729803 hasConceptScore W4285729803C185592680 @default.
- W4285729803 hasConceptScore W4285729803C199539241 @default.
- W4285729803 hasConceptScore W4285729803C2776359362 @default.
- W4285729803 hasConceptScore W4285729803C41008148 @default.
- W4285729803 hasConceptScore W4285729803C41608201 @default.
- W4285729803 hasConceptScore W4285729803C44000306 @default.
- W4285729803 hasConceptScore W4285729803C54355233 @default.