Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285732011> ?p ?o ?g. }
- W4285732011 endingPage "4149" @default.
- W4285732011 startingPage "4149" @default.
- W4285732011 abstract "Background: To date, no consistent data are available on the possible impact of CFTR modulators on glucose metabolism. The aim of this study was to test the hypothesis that treatment with CFTR modulators is associated with an improvement in the key direct determinants of glucose regulation in children and young adults affected by Cystic Fibrosis (CF). Methods: In this study, 21 CF patients aged 10–25 underwent oral glucose tolerance test (OGTT) before and after 12–18 months of treatment with Lumacaftor/Ivacaftor or Elexacaftor-Ivacaftor-Tezacaftor. β-cell function (i.e., first and second phase of insulin secretion measured as derivative and proportional control, respectively) and insulin clearance were estimated by OGTT mathematical modelling. Insulin sensitivity was estimated by the Oral Glucose Sensitivity Index (OGIS). The dynamic interplay between β-cell function, insulin clearance and insulin sensitivity was analysed by vector plots of glucose-stimulated insulin bioavailability vs. insulin sensitivity. Results: No changes in glucose tolerance occurred after either treatment, whereas a significant improvement in pulmonary function and chronic bacterial infection was observed. Beta cell function and insulin clearance did not change in both treatment groups. Insulin sensitivity worsened in the Lumacaftor/Ivacaftor group. The analysis of vector plots confirmed that glucose regulation was stable in both groups. Conclusions: Treatment of CF patients with CFTR modulators does not significantly ameliorate glucose homeostasis and/or any of its direct determinants." @default.
- W4285732011 created "2022-07-18" @default.
- W4285732011 creator A5002314055 @default.
- W4285732011 creator A5005911906 @default.
- W4285732011 creator A5006141192 @default.
- W4285732011 creator A5015697536 @default.
- W4285732011 creator A5019204267 @default.
- W4285732011 creator A5027649273 @default.
- W4285732011 creator A5033692164 @default.
- W4285732011 creator A5034234671 @default.
- W4285732011 creator A5037721874 @default.
- W4285732011 creator A5043405461 @default.
- W4285732011 creator A5050145548 @default.
- W4285732011 creator A5065186921 @default.
- W4285732011 creator A5068659305 @default.
- W4285732011 creator A5080239986 @default.
- W4285732011 creator A5090764509 @default.
- W4285732011 date "2022-07-17" @default.
- W4285732011 modified "2023-10-18" @default.
- W4285732011 title "Impact of CFTR Modulators on Beta-Cell Function in Children and Young Adults with Cystic Fibrosis" @default.
- W4285732011 cites W1504170793 @default.
- W4285732011 cites W1510427588 @default.
- W4285732011 cites W1924064069 @default.
- W4285732011 cites W2008985050 @default.
- W4285732011 cites W2019133751 @default.
- W4285732011 cites W2019993996 @default.
- W4285732011 cites W2059516713 @default.
- W4285732011 cites W2081657572 @default.
- W4285732011 cites W2111473023 @default.
- W4285732011 cites W2114854928 @default.
- W4285732011 cites W2127277443 @default.
- W4285732011 cites W2127358544 @default.
- W4285732011 cites W2133073268 @default.
- W4285732011 cites W2147821592 @default.
- W4285732011 cites W2150709240 @default.
- W4285732011 cites W2152703443 @default.
- W4285732011 cites W2171472692 @default.
- W4285732011 cites W2183555230 @default.
- W4285732011 cites W2409183258 @default.
- W4285732011 cites W2496297269 @default.
- W4285732011 cites W2775094274 @default.
- W4285732011 cites W2802569467 @default.
- W4285732011 cites W2808871427 @default.
- W4285732011 cites W2888375595 @default.
- W4285732011 cites W2912589944 @default.
- W4285732011 cites W2952529739 @default.
- W4285732011 cites W2969483245 @default.
- W4285732011 cites W2981067716 @default.
- W4285732011 cites W2985266424 @default.
- W4285732011 cites W2991267152 @default.
- W4285732011 cites W3012476207 @default.
- W4285732011 cites W3083960198 @default.
- W4285732011 cites W3109501881 @default.
- W4285732011 cites W3110766335 @default.
- W4285732011 cites W3111980965 @default.
- W4285732011 cites W3131324876 @default.
- W4285732011 cites W3166702694 @default.
- W4285732011 cites W3182318848 @default.
- W4285732011 cites W3199130498 @default.
- W4285732011 doi "https://doi.org/10.3390/jcm11144149" @default.
- W4285732011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35887914" @default.
- W4285732011 hasPublicationYear "2022" @default.
- W4285732011 type Work @default.
- W4285732011 citedByCount "9" @default.
- W4285732011 countsByYear W42857320112023 @default.
- W4285732011 crossrefType "journal-article" @default.
- W4285732011 hasAuthorship W4285732011A5002314055 @default.
- W4285732011 hasAuthorship W4285732011A5005911906 @default.
- W4285732011 hasAuthorship W4285732011A5006141192 @default.
- W4285732011 hasAuthorship W4285732011A5015697536 @default.
- W4285732011 hasAuthorship W4285732011A5019204267 @default.
- W4285732011 hasAuthorship W4285732011A5027649273 @default.
- W4285732011 hasAuthorship W4285732011A5033692164 @default.
- W4285732011 hasAuthorship W4285732011A5034234671 @default.
- W4285732011 hasAuthorship W4285732011A5037721874 @default.
- W4285732011 hasAuthorship W4285732011A5043405461 @default.
- W4285732011 hasAuthorship W4285732011A5050145548 @default.
- W4285732011 hasAuthorship W4285732011A5065186921 @default.
- W4285732011 hasAuthorship W4285732011A5068659305 @default.
- W4285732011 hasAuthorship W4285732011A5080239986 @default.
- W4285732011 hasAuthorship W4285732011A5090764509 @default.
- W4285732011 hasBestOaLocation W42857320111 @default.
- W4285732011 hasConcept C126322002 @default.
- W4285732011 hasConcept C134018914 @default.
- W4285732011 hasConcept C17093226 @default.
- W4285732011 hasConcept C2776502428 @default.
- W4285732011 hasConcept C2776938444 @default.
- W4285732011 hasConcept C2777391703 @default.
- W4285732011 hasConcept C2778428886 @default.
- W4285732011 hasConcept C2779306644 @default.
- W4285732011 hasConcept C2780833929 @default.
- W4285732011 hasConcept C3017594256 @default.
- W4285732011 hasConcept C3018667095 @default.
- W4285732011 hasConcept C555293320 @default.
- W4285732011 hasConcept C63645605 @default.
- W4285732011 hasConcept C71924100 @default.
- W4285732011 hasConceptScore W4285732011C126322002 @default.
- W4285732011 hasConceptScore W4285732011C134018914 @default.