Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285733513> ?p ?o ?g. }
- W4285733513 endingPage "1480" @default.
- W4285733513 startingPage "1480" @default.
- W4285733513 abstract "In the present study, gastro-resistant microparticles (MPs) were produced using the spray-drying technique as controlled-release systems for some model liposoluble vitamins, including retinyl-palmitate, retinyl-acetate, β-carotene, cholecalciferol and α-tocopherol. The gastroprotective action of three different gastro-resistant excipients, the anionic methacrylic copolymer (Eudraguard®® Biotic, E1207), the cellulose acetate phthalate (CAP) and whey proteins (WPs), was compared. The latter was used to produce a novel delivery system manufactured with only food-derived components, such as milk, and showed several improvements over the two synthetic gastro-resistant agents. Scanning electron microscopy (SEM) images showed a quite homogeneous spherical shape of all microparticle batches, with an average diameter between 7 and 15 μm. FTIR analysis was used to evaluate the effective incorporation of vitamins within the microparticles and the absence of any degradation to the components of the formulation. The comparison graphs of differential scanning calorimetry (DSC) confirmed that the spray drying technique generates a solid in which the physical interactions between the excipients and the vitamins are very strong. Release studies showed a prominent pH-controlled release and partially a delayed-release profile. Ex vivo permeation studies of retinyl palmitate, retinyl acetate and α-tocopherol revealed greater transmucosal permeation capacity for microparticles produced with the WPs and milk." @default.
- W4285733513 created "2022-07-18" @default.
- W4285733513 creator A5006583048 @default.
- W4285733513 creator A5026243912 @default.
- W4285733513 creator A5040668512 @default.
- W4285733513 creator A5079930659 @default.
- W4285733513 creator A5090532766 @default.
- W4285733513 date "2022-07-15" @default.
- W4285733513 modified "2023-09-27" @default.
- W4285733513 title "Gastro-Resistant Microparticles Produced by Spray-Drying as Controlled Release Systems for Liposoluble Vitamins" @default.
- W4285733513 cites W1965360500 @default.
- W4285733513 cites W1975868078 @default.
- W4285733513 cites W1994771061 @default.
- W4285733513 cites W1998126370 @default.
- W4285733513 cites W2000730170 @default.
- W4285733513 cites W2014879978 @default.
- W4285733513 cites W2022869901 @default.
- W4285733513 cites W2032989482 @default.
- W4285733513 cites W2034808342 @default.
- W4285733513 cites W2040521258 @default.
- W4285733513 cites W2055968474 @default.
- W4285733513 cites W2079633519 @default.
- W4285733513 cites W2081202706 @default.
- W4285733513 cites W2086762638 @default.
- W4285733513 cites W2587983561 @default.
- W4285733513 cites W2588166728 @default.
- W4285733513 cites W2765299354 @default.
- W4285733513 cites W2912941728 @default.
- W4285733513 cites W2940872955 @default.
- W4285733513 cites W2971462171 @default.
- W4285733513 cites W2981490594 @default.
- W4285733513 cites W3008335090 @default.
- W4285733513 cites W3017083809 @default.
- W4285733513 cites W3021657205 @default.
- W4285733513 cites W3037100894 @default.
- W4285733513 cites W3044100501 @default.
- W4285733513 cites W3195426841 @default.
- W4285733513 cites W3201331693 @default.
- W4285733513 cites W347376517 @default.
- W4285733513 cites W4205108637 @default.
- W4285733513 cites W4206414763 @default.
- W4285733513 cites W4213422893 @default.
- W4285733513 doi "https://doi.org/10.3390/pharmaceutics14071480" @default.
- W4285733513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35890375" @default.
- W4285733513 hasPublicationYear "2022" @default.
- W4285733513 type Work @default.
- W4285733513 citedByCount "1" @default.
- W4285733513 countsByYear W42857335132023 @default.
- W4285733513 crossrefType "journal-article" @default.
- W4285733513 hasAuthorship W4285733513A5006583048 @default.
- W4285733513 hasAuthorship W4285733513A5026243912 @default.
- W4285733513 hasAuthorship W4285733513A5040668512 @default.
- W4285733513 hasAuthorship W4285733513A5079930659 @default.
- W4285733513 hasAuthorship W4285733513A5090532766 @default.
- W4285733513 hasBestOaLocation W42857335131 @default.
- W4285733513 hasConcept C121332964 @default.
- W4285733513 hasConcept C127413603 @default.
- W4285733513 hasConcept C155672457 @default.
- W4285733513 hasConcept C163588942 @default.
- W4285733513 hasConcept C171250308 @default.
- W4285733513 hasConcept C185592680 @default.
- W4285733513 hasConcept C192562407 @default.
- W4285733513 hasConcept C2776940978 @default.
- W4285733513 hasConcept C2777118752 @default.
- W4285733513 hasConcept C2777326149 @default.
- W4285733513 hasConcept C2777521759 @default.
- W4285733513 hasConcept C2779251873 @default.
- W4285733513 hasConcept C2779573558 @default.
- W4285733513 hasConcept C2779587474 @default.
- W4285733513 hasConcept C31903555 @default.
- W4285733513 hasConcept C39519442 @default.
- W4285733513 hasConcept C41625074 @default.
- W4285733513 hasConcept C42360764 @default.
- W4285733513 hasConcept C43617362 @default.
- W4285733513 hasConcept C50670333 @default.
- W4285733513 hasConcept C55493867 @default.
- W4285733513 hasConcept C86181022 @default.
- W4285733513 hasConcept C97355855 @default.
- W4285733513 hasConceptScore W4285733513C121332964 @default.
- W4285733513 hasConceptScore W4285733513C127413603 @default.
- W4285733513 hasConceptScore W4285733513C155672457 @default.
- W4285733513 hasConceptScore W4285733513C163588942 @default.
- W4285733513 hasConceptScore W4285733513C171250308 @default.
- W4285733513 hasConceptScore W4285733513C185592680 @default.
- W4285733513 hasConceptScore W4285733513C192562407 @default.
- W4285733513 hasConceptScore W4285733513C2776940978 @default.
- W4285733513 hasConceptScore W4285733513C2777118752 @default.
- W4285733513 hasConceptScore W4285733513C2777326149 @default.
- W4285733513 hasConceptScore W4285733513C2777521759 @default.
- W4285733513 hasConceptScore W4285733513C2779251873 @default.
- W4285733513 hasConceptScore W4285733513C2779573558 @default.
- W4285733513 hasConceptScore W4285733513C2779587474 @default.
- W4285733513 hasConceptScore W4285733513C31903555 @default.
- W4285733513 hasConceptScore W4285733513C39519442 @default.
- W4285733513 hasConceptScore W4285733513C41625074 @default.
- W4285733513 hasConceptScore W4285733513C42360764 @default.
- W4285733513 hasConceptScore W4285733513C43617362 @default.
- W4285733513 hasConceptScore W4285733513C50670333 @default.