Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285733874> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4285733874 endingPage "1550" @default.
- W4285733874 startingPage "1550" @default.
- W4285733874 abstract "Circoviruses are the smallest single-stranded DNA viruses that infect mammalian species, avian species, fish, and insects. The infections of circoviruses are known to be associated with a series of fatal diseases, but the protease of circovirus still remains unknown. In this research, we identified viral capsid protein (Cap) as the protease of porcine circovirus type 2 (PCV2), to our knowledge the first circoviruses protease to be reported. First, we found that the expression of host proteins is affected due to PCV2 infection in the porcine kidney (PK-15) cells. Then, by proteomic analysis, 253 host proteins that were down regulated were identified due to direct or indirect effects of PCV2. Further, Cap expression, but not other ORFs of PCV2, significantly reduced both JMJD6 (bifunctional arginine demethylase and lysyl-hydroxylase) and CCT5 (the chaperonin containing TCP1 subunit 5) in PK-15 cells. Finally, the results in vitro hydrolysis assays demonstrated that Cap could directly degraded either JMJD6 or CCT5 with different catalytic efficiency. In summary, our study expands repertoire of PCV2 Cap and promotes the development of inhibitors toward the anti-PCV2." @default.
- W4285733874 created "2022-07-18" @default.
- W4285733874 creator A5009310435 @default.
- W4285733874 creator A5016130612 @default.
- W4285733874 creator A5058079930 @default.
- W4285733874 creator A5069318439 @default.
- W4285733874 creator A5076699095 @default.
- W4285733874 creator A5081676882 @default.
- W4285733874 creator A5087847070 @default.
- W4285733874 date "2022-07-15" @default.
- W4285733874 modified "2023-09-30" @default.
- W4285733874 title "Cap Is the Protease of the Porcine Circovirus 2" @default.
- W4285733874 cites W1664402626 @default.
- W4285733874 cites W1978718965 @default.
- W4285733874 cites W1983170246 @default.
- W4285733874 cites W1990559162 @default.
- W4285733874 cites W2003408366 @default.
- W4285733874 cites W2011614230 @default.
- W4285733874 cites W2044168200 @default.
- W4285733874 cites W2066904072 @default.
- W4285733874 cites W2105889769 @default.
- W4285733874 cites W2110808927 @default.
- W4285733874 cites W2120764395 @default.
- W4285733874 cites W2130253098 @default.
- W4285733874 cites W2147997790 @default.
- W4285733874 cites W2153314219 @default.
- W4285733874 cites W2165055155 @default.
- W4285733874 cites W2763547223 @default.
- W4285733874 cites W2768652310 @default.
- W4285733874 cites W4210955468 @default.
- W4285733874 cites W91971790 @default.
- W4285733874 doi "https://doi.org/10.3390/v14071550" @default.
- W4285733874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35891530" @default.
- W4285733874 hasPublicationYear "2022" @default.
- W4285733874 type Work @default.
- W4285733874 citedByCount "1" @default.
- W4285733874 countsByYear W42857338742023 @default.
- W4285733874 crossrefType "journal-article" @default.
- W4285733874 hasAuthorship W4285733874A5009310435 @default.
- W4285733874 hasAuthorship W4285733874A5016130612 @default.
- W4285733874 hasAuthorship W4285733874A5058079930 @default.
- W4285733874 hasAuthorship W4285733874A5069318439 @default.
- W4285733874 hasAuthorship W4285733874A5076699095 @default.
- W4285733874 hasAuthorship W4285733874A5081676882 @default.
- W4285733874 hasAuthorship W4285733874A5087847070 @default.
- W4285733874 hasBestOaLocation W42857338741 @default.
- W4285733874 hasConcept C153911025 @default.
- W4285733874 hasConcept C159047783 @default.
- W4285733874 hasConcept C181199279 @default.
- W4285733874 hasConcept C182220744 @default.
- W4285733874 hasConcept C202878990 @default.
- W4285733874 hasConcept C2522874641 @default.
- W4285733874 hasConcept C2776714187 @default.
- W4285733874 hasConcept C2779231742 @default.
- W4285733874 hasConcept C2781045504 @default.
- W4285733874 hasConcept C55493867 @default.
- W4285733874 hasConcept C86803240 @default.
- W4285733874 hasConceptScore W4285733874C153911025 @default.
- W4285733874 hasConceptScore W4285733874C159047783 @default.
- W4285733874 hasConceptScore W4285733874C181199279 @default.
- W4285733874 hasConceptScore W4285733874C182220744 @default.
- W4285733874 hasConceptScore W4285733874C202878990 @default.
- W4285733874 hasConceptScore W4285733874C2522874641 @default.
- W4285733874 hasConceptScore W4285733874C2776714187 @default.
- W4285733874 hasConceptScore W4285733874C2779231742 @default.
- W4285733874 hasConceptScore W4285733874C2781045504 @default.
- W4285733874 hasConceptScore W4285733874C55493867 @default.
- W4285733874 hasConceptScore W4285733874C86803240 @default.
- W4285733874 hasFunder F4320325562 @default.
- W4285733874 hasIssue "7" @default.
- W4285733874 hasLocation W42857338741 @default.
- W4285733874 hasLocation W42857338742 @default.
- W4285733874 hasLocation W42857338743 @default.
- W4285733874 hasOpenAccess W4285733874 @default.
- W4285733874 hasPrimaryLocation W42857338741 @default.
- W4285733874 hasRelatedWork W107018270 @default.
- W4285733874 hasRelatedWork W2001012225 @default.
- W4285733874 hasRelatedWork W2007561664 @default.
- W4285733874 hasRelatedWork W2107865312 @default.
- W4285733874 hasRelatedWork W2531515272 @default.
- W4285733874 hasRelatedWork W2754396944 @default.
- W4285733874 hasRelatedWork W2783646741 @default.
- W4285733874 hasRelatedWork W3120659120 @default.
- W4285733874 hasRelatedWork W3181199134 @default.
- W4285733874 hasRelatedWork W4288046429 @default.
- W4285733874 hasVolume "14" @default.
- W4285733874 isParatext "false" @default.
- W4285733874 isRetracted "false" @default.
- W4285733874 workType "article" @default.