FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285736900> ?p ?o ?g. }

• W4285736900 endingPage "138137" @default.
• W4285736900 startingPage "138137" @default.
• W4285736900 abstract "Activatable nanosystem for cancer therapy are of considerable attention in the field of theranostics. Nevertheless, constructing activatable nanosystem with specific response performance and turn “on–off” treatment mode still remains an enormous challenge. Here, we developed a cascade reaction nanomedicine for highly efficient cancer theranostics by constructing and delivering multifunctional activatable nanocapsules into the tumor region. 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS, activatable agent) and camptothecin (CPT, chemotherapeutic drug) have been encapsulated into large pore-sized dendritic macroporous silica coated Fe3O4 nanocapsules (Fe3O4@DMSN), further modified with poly(vinylpyrrolidone) (PVP) to improve the solubility and biocompatibility, defined as [email protected] NCs. The prepared nanocapsules can be specifically responded to tumor microenvironment by a nanozyme-catalyzed two-step acceleration process to turn on its hyperthermia effect and imaging performance due to the production of oxidized ABTS, simultaneously. Moreover, the generating hydroxyl radicals are attributed to the overexpressed H2O2 in the tumor microenvironment and the self-depletion intracellular GSH endow [email protected] with the capability of promoted chemodynamic therapy, therefore resulting in significant therapeutic effect in connection with chemotherapy and tumor microenvironment-mediated photothermal therapy. What’s more, the H2O2-activated and tumor microenvironment improved profiles endow the nanocapsules to be specific to tumors, avoiding the damage to normal tissue. These prominent characteristics of [email protected] NCs may open up a new trail to explore activatable nanoplatform for imaging-directed smart, precise, and noninvasive tumor theranostics." @default.
• W4285736900 created "2022-07-18" @default.
• W4285736900 creator A5003522943 @default.
• W4285736900 creator A5033129101 @default.
• W4285736900 creator A5042237918 @default.
• W4285736900 creator A5045309022 @default.
• W4285736900 creator A5048826252 @default.
• W4285736900 creator A5051519108 @default.
• W4285736900 creator A5059389033 @default.
• W4285736900 creator A5065223693 @default.
• W4285736900 creator A5065637954 @default.
• W4285736900 creator A5068723280 @default.
• W4285736900 date "2022-12-01" @default.
• W4285736900 modified "2023-10-14" @default.
• W4285736900 title "Tumor microenvironment activated glutathione self-depletion theranostic nanocapsules for imaging-directed synergistic cancer therapy" @default.
• W4285736900 cites W1678884887 @default.
• W4285736900 cites W1972832452 @default.
• W4285736900 cites W2041648514 @default.
• W4285736900 cites W2042138520 @default.
• W4285736900 cites W2229268188 @default.
• W4285736900 cites W2398986011 @default.
• W4285736900 cites W2569530200 @default.
• W4285736900 cites W2615993918 @default.
• W4285736900 cites W2728722006 @default.
• W4285736900 cites W2747423355 @default.
• W4285736900 cites W2766554468 @default.
• W4285736900 cites W2787460561 @default.
• W4285736900 cites W2793503277 @default.
• W4285736900 cites W2804721694 @default.
• W4285736900 cites W2889742140 @default.
• W4285736900 cites W2896035171 @default.
• W4285736900 cites W2907278948 @default.
• W4285736900 cites W2913429346 @default.
• W4285736900 cites W2936513263 @default.
• W4285736900 cites W2952331148 @default.
• W4285736900 cites W2952499681 @default.
• W4285736900 cites W2969296993 @default.
• W4285736900 cites W2969836098 @default.
• W4285736900 cites W2977879878 @default.
• W4285736900 cites W2982280565 @default.
• W4285736900 cites W2984026802 @default.
• W4285736900 cites W2987501108 @default.
• W4285736900 cites W2995385480 @default.
• W4285736900 cites W3011335061 @default.
• W4285736900 cites W3015714009 @default.
• W4285736900 cites W3021980235 @default.
• W4285736900 cites W3048510814 @default.
• W4285736900 cites W3086396309 @default.
• W4285736900 cites W3093795255 @default.
• W4285736900 cites W3097560427 @default.
• W4285736900 cites W3112340938 @default.
• W4285736900 cites W3125711003 @default.
• W4285736900 cites W3136252736 @default.
• W4285736900 cites W3148113482 @default.
• W4285736900 cites W3148405623 @default.
• W4285736900 cites W3194110152 @default.
• W4285736900 cites W3201882315 @default.
• W4285736900 cites W3201967662 @default.
• W4285736900 cites W3204165958 @default.
• W4285736900 cites W3206546024 @default.
• W4285736900 cites W3208486179 @default.
• W4285736900 cites W4200483722 @default.
• W4285736900 cites W4206911311 @default.
• W4285736900 cites W4210263703 @default.
• W4285736900 cites W4214484048 @default.
• W4285736900 cites W4220869079 @default.
• W4285736900 cites W4220998645 @default.
• W4285736900 cites W4251271452 @default.
• W4285736900 cites W4379087938 @default.
• W4285736900 doi "https://doi.org/10.1016/j.cej.2022.138137" @default.
• W4285736900 hasPublicationYear "2022" @default.
• W4285736900 type Work @default.
• W4285736900 citedByCount "4" @default.
• W4285736900 countsByYear W42857369002023 @default.
• W4285736900 crossrefType "journal-article" @default.
• W4285736900 hasAuthorship W4285736900A5003522943 @default.
• W4285736900 hasAuthorship W4285736900A5033129101 @default.
• W4285736900 hasAuthorship W4285736900A5042237918 @default.
• W4285736900 hasAuthorship W4285736900A5045309022 @default.
• W4285736900 hasAuthorship W4285736900A5048826252 @default.
• W4285736900 hasAuthorship W4285736900A5051519108 @default.
• W4285736900 hasAuthorship W4285736900A5059389033 @default.
• W4285736900 hasAuthorship W4285736900A5065223693 @default.
• W4285736900 hasAuthorship W4285736900A5065637954 @default.
• W4285736900 hasAuthorship W4285736900A5068723280 @default.
• W4285736900 hasConcept C12554922 @default.
• W4285736900 hasConcept C15083742 @default.
• W4285736900 hasConcept C155672457 @default.
• W4285736900 hasConcept C171250308 @default.
• W4285736900 hasConcept C178790620 @default.
• W4285736900 hasConcept C18150654 @default.
• W4285736900 hasConcept C182606246 @default.
• W4285736900 hasConcept C185592680 @default.
• W4285736900 hasConcept C192562407 @default.
• W4285736900 hasConcept C204399865 @default.
• W4285736900 hasConcept C2776107976 @default.
• W4285736900 hasConcept C2777230088 @default.
• W4285736900 hasConcept C2779820397 @default.

• next