Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285741128> ?p ?o ?g. }
- W4285741128 abstract "Selaginella doederleinii Hieron is a traditional Chinese medicinal herb widely used to treat different cancers. Previously, we showed that the total bioflavonoid extract of S. doederleinii (TBESD) exhibits anti-carcinogenic activities both in vitro and in vivo . However, the plasma protein binding and pharmacokinetics parameters of TBESD remain unclear. To investigate plasma protein binding, tissue distribution, and excretion of TBESD, rats were administered a single dose of TBESD (600 mg/kg) intragastrically and tissue distribution and excretion of TBESD components were determined by rapid high-performance liquid chromatography and tandem mass spectrometry. TBESD binding to human serum albumin (HSA) was assessed by fluorescence spectroscopy. TBESD components amentoflavone, delicaflavone, robustaflavone, 2″,3″-dihydro-3′,3‴-biapigenin, and 3′,3‴-binaringenin were rapidly absorbed and distributed in various tissues, mostly in the lungs, kidneys, and ovaries, without long-term accumulation. The excretion of bioflavonoids occurred mostly via the intestinal tract and constituted 30% of the administered dose up to 48 h. Spectral analysis indicated that TBESD had a dynamic quenching effect on HSA by binding to one HSA site through hydrophobic interactions and hydrogen bond formation. This is the first comprehensive report on the tissue distribution, excretion, and plasma protein binding of TBESD. This study provides important information on TBESD pharmacokinetics necessary for its further development into a therapeutic form for clinical applications." @default.
- W4285741128 created "2022-07-18" @default.
- W4285741128 creator A5002876333 @default.
- W4285741128 creator A5004757794 @default.
- W4285741128 creator A5005496259 @default.
- W4285741128 creator A5008554297 @default.
- W4285741128 creator A5016586260 @default.
- W4285741128 creator A5019518812 @default.
- W4285741128 creator A5027223987 @default.
- W4285741128 creator A5056869471 @default.
- W4285741128 creator A5073524555 @default.
- W4285741128 creator A5077604881 @default.
- W4285741128 creator A5082668462 @default.
- W4285741128 date "2022-04-29" @default.
- W4285741128 modified "2023-10-18" @default.
- W4285741128 title "Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract From Selaginella doederleinii" @default.
- W4285741128 cites W1906607230 @default.
- W4285741128 cites W1994078041 @default.
- W4285741128 cites W2161106472 @default.
- W4285741128 cites W2293181601 @default.
- W4285741128 cites W2417562061 @default.
- W4285741128 cites W2548898110 @default.
- W4285741128 cites W2550762087 @default.
- W4285741128 cites W2554597529 @default.
- W4285741128 cites W2557056866 @default.
- W4285741128 cites W2590635691 @default.
- W4285741128 cites W2594932855 @default.
- W4285741128 cites W2767084125 @default.
- W4285741128 cites W2776363656 @default.
- W4285741128 cites W2883288679 @default.
- W4285741128 cites W2892222865 @default.
- W4285741128 cites W2894952529 @default.
- W4285741128 cites W2896220888 @default.
- W4285741128 cites W2901516736 @default.
- W4285741128 cites W2944865378 @default.
- W4285741128 cites W2945010855 @default.
- W4285741128 cites W2958000770 @default.
- W4285741128 cites W2969439826 @default.
- W4285741128 cites W2981132553 @default.
- W4285741128 cites W2981722081 @default.
- W4285741128 cites W2995076164 @default.
- W4285741128 cites W3002801594 @default.
- W4285741128 cites W3006521225 @default.
- W4285741128 cites W3010213197 @default.
- W4285741128 cites W3039700603 @default.
- W4285741128 cites W3092683011 @default.
- W4285741128 cites W3106562927 @default.
- W4285741128 cites W3112900069 @default.
- W4285741128 cites W3121014675 @default.
- W4285741128 cites W3129779260 @default.
- W4285741128 cites W3170503105 @default.
- W4285741128 cites W3197344038 @default.
- W4285741128 cites W3211566953 @default.
- W4285741128 cites W3212898523 @default.
- W4285741128 cites W4241252418 @default.
- W4285741128 doi "https://doi.org/10.3389/fphar.2022.849110" @default.
- W4285741128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35571075" @default.
- W4285741128 hasPublicationYear "2022" @default.
- W4285741128 type Work @default.
- W4285741128 citedByCount "0" @default.
- W4285741128 crossrefType "journal-article" @default.
- W4285741128 hasAuthorship W4285741128A5002876333 @default.
- W4285741128 hasAuthorship W4285741128A5004757794 @default.
- W4285741128 hasAuthorship W4285741128A5005496259 @default.
- W4285741128 hasAuthorship W4285741128A5008554297 @default.
- W4285741128 hasAuthorship W4285741128A5016586260 @default.
- W4285741128 hasAuthorship W4285741128A5019518812 @default.
- W4285741128 hasAuthorship W4285741128A5027223987 @default.
- W4285741128 hasAuthorship W4285741128A5056869471 @default.
- W4285741128 hasAuthorship W4285741128A5073524555 @default.
- W4285741128 hasAuthorship W4285741128A5077604881 @default.
- W4285741128 hasAuthorship W4285741128A5082668462 @default.
- W4285741128 hasBestOaLocation W42857411281 @default.
- W4285741128 hasConcept C10146269 @default.
- W4285741128 hasConcept C112705442 @default.
- W4285741128 hasConcept C146543888 @default.
- W4285741128 hasConcept C150903083 @default.
- W4285741128 hasConcept C185592680 @default.
- W4285741128 hasConcept C207001950 @default.
- W4285741128 hasConcept C2776125364 @default.
- W4285741128 hasConcept C2778597219 @default.
- W4285741128 hasConcept C55493867 @default.
- W4285741128 hasConcept C86803240 @default.
- W4285741128 hasConcept C98274493 @default.
- W4285741128 hasConceptScore W4285741128C10146269 @default.
- W4285741128 hasConceptScore W4285741128C112705442 @default.
- W4285741128 hasConceptScore W4285741128C146543888 @default.
- W4285741128 hasConceptScore W4285741128C150903083 @default.
- W4285741128 hasConceptScore W4285741128C185592680 @default.
- W4285741128 hasConceptScore W4285741128C207001950 @default.
- W4285741128 hasConceptScore W4285741128C2776125364 @default.
- W4285741128 hasConceptScore W4285741128C2778597219 @default.
- W4285741128 hasConceptScore W4285741128C55493867 @default.
- W4285741128 hasConceptScore W4285741128C86803240 @default.
- W4285741128 hasConceptScore W4285741128C98274493 @default.
- W4285741128 hasFunder F4320321001 @default.
- W4285741128 hasFunder F4320321878 @default.
- W4285741128 hasLocation W42857411281 @default.
- W4285741128 hasLocation W42857411282 @default.
- W4285741128 hasLocation W42857411283 @default.