FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285741891> ?p ?o ?g. }

• W4285741891 endingPage "270" @default.
• W4285741891 startingPage "231" @default.
• W4285741891 abstract "Osteoporosis is a significant health problem, with skeletal fractures increasing morbidity and mortality. Excess glucocorticoids (GC) represents the leading cause of secondary osteoporosis. The first phase of glucocorticoid-induced osteoporosis is increased bone resorption. In this Chapter, in vitro studies of the direct glucocorticoid receptor (GR) mediated cellular effects of GC on osteoclasts to affect bone resorption and indirect effects on osteoblast lineage cells to increase the RANKL/OPG ratio and stimulate osteoclastogenesis and bone resorption are reviewed in detail, together with detailed descriptions of in vivo effects of GC in different portions of the skeleton in research animals and humans. Brief sections are devoted to contrasting functions of GC in osteonecrosis, vitamin D formation, in vitro and in vivo bone resorptive actions dependent on vitamin D receptor and vitamin D toxicity, as well as the molecular basis of GR action. Included are also more detailed assessments of the interactions of GC with the major calcium regulating hormones, 1,25(OH)2-vitamin D3 and parathyroid hormone, describing the in vitro increases in RANKL/OPG ratios, osteoclastogenesis and synergistic bone resorption that occurs when GC is combined with either 1,25(OH)2-vitamin D3 or parathyroid hormone. Additionally, a molecular basic for the synergistic interaction of GC with 1,25(OH)2-vitamin D3 is provided along with a suggested molecular basic for the interaction between GC and parathyroid hormone." @default.
• W4285741891 created "2022-07-18" @default.
• W4285741891 creator A5019689323 @default.
• W4285741891 creator A5047793230 @default.
• W4285741891 creator A5059269242 @default.
• W4285741891 date "2022-01-01" @default.
• W4285741891 modified "2023-10-03" @default.
• W4285741891 title "Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3" @default.
• W4285741891 cites W1520730348 @default.
• W4285741891 cites W1534645474 @default.
• W4285741891 cites W1551136566 @default.
• W4285741891 cites W1874408158 @default.
• W4285741891 cites W1891625866 @default.
• W4285741891 cites W1897274595 @default.
• W4285741891 cites W1902098806 @default.
• W4285741891 cites W1963556204 @default.
• W4285741891 cites W1964454575 @default.
• W4285741891 cites W1967301186 @default.
• W4285741891 cites W1969429995 @default.
• W4285741891 cites W1969464592 @default.
• W4285741891 cites W1971211179 @default.
• W4285741891 cites W1971501588 @default.
• W4285741891 cites W1972285228 @default.
• W4285741891 cites W1972567404 @default.
• W4285741891 cites W1976050918 @default.
• W4285741891 cites W1978136096 @default.
• W4285741891 cites W1978968292 @default.
• W4285741891 cites W1980418071 @default.
• W4285741891 cites W1982395713 @default.
• W4285741891 cites W1982615479 @default.
• W4285741891 cites W1982945684 @default.
• W4285741891 cites W1984126393 @default.
• W4285741891 cites W1987608927 @default.
• W4285741891 cites W1988694418 @default.
• W4285741891 cites W1996296651 @default.
• W4285741891 cites W1997031417 @default.
• W4285741891 cites W1997510672 @default.
• W4285741891 cites W1997966580 @default.
• W4285741891 cites W1998000745 @default.
• W4285741891 cites W1999032828 @default.
• W4285741891 cites W1999319214 @default.
• W4285741891 cites W2000647744 @default.
• W4285741891 cites W2002315967 @default.
• W4285741891 cites W2002629371 @default.
• W4285741891 cites W2005123937 @default.
• W4285741891 cites W2007169317 @default.
• W4285741891 cites W2007731700 @default.
• W4285741891 cites W2008585978 @default.
• W4285741891 cites W2011203192 @default.
• W4285741891 cites W2018602999 @default.
• W4285741891 cites W2020229324 @default.
• W4285741891 cites W2020765879 @default.
• W4285741891 cites W2021280621 @default.
• W4285741891 cites W2024712262 @default.
• W4285741891 cites W2025660877 @default.
• W4285741891 cites W2031532064 @default.
• W4285741891 cites W2033866180 @default.
• W4285741891 cites W2034528005 @default.
• W4285741891 cites W2034541958 @default.
• W4285741891 cites W2034716448 @default.
• W4285741891 cites W2035000923 @default.
• W4285741891 cites W2035254675 @default.
• W4285741891 cites W2038281561 @default.
• W4285741891 cites W2038469606 @default.
• W4285741891 cites W2040337853 @default.
• W4285741891 cites W2040452815 @default.
• W4285741891 cites W2040734947 @default.
• W4285741891 cites W2043651158 @default.
• W4285741891 cites W2045008807 @default.
• W4285741891 cites W2048730055 @default.
• W4285741891 cites W2048996241 @default.
• W4285741891 cites W2049671131 @default.
• W4285741891 cites W2050104200 @default.
• W4285741891 cites W2052379922 @default.
• W4285741891 cites W2054866872 @default.
• W4285741891 cites W2056253305 @default.
• W4285741891 cites W2056681753 @default.
• W4285741891 cites W2060037483 @default.
• W4285741891 cites W2062447638 @default.
• W4285741891 cites W2064603645 @default.
• W4285741891 cites W2065317510 @default.
• W4285741891 cites W2072697232 @default.
• W4285741891 cites W2073739957 @default.
• W4285741891 cites W2074405142 @default.
• W4285741891 cites W2074559070 @default.
• W4285741891 cites W2077803308 @default.
• W4285741891 cites W2079911260 @default.
• W4285741891 cites W2080570046 @default.
• W4285741891 cites W2081885660 @default.
• W4285741891 cites W2085368041 @default.
• W4285741891 cites W2086037419 @default.
• W4285741891 cites W2091773006 @default.
• W4285741891 cites W2093859462 @default.
• W4285741891 cites W2093915139 @default.
• W4285741891 cites W2096992703 @default.
• W4285741891 cites W2099527909 @default.
• W4285741891 cites W2101487607 @default.
• W4285741891 cites W2102680446 @default.

• next