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- W4285742092 abstract "There are many clinical trials underway for the development of gene therapies, and some have resulted in gene therapy products being commercially approved already. Significant progress was made to develop safer and more effective strategies to deliver and regulate genetic products. An unsolved aspect is the immune system, which can affect the efficiency of gene therapy in different ways. Here we present an overview of approved gene therapy products and the immune response elicited by gene delivery systems. These include responses against the vector or its content after delivery and against the product of the corrected gene. Strategies to overcome the hurdles include hiding the vector or/and the transgene product from the immune system and hiding the immune system from the vector/transgene product. Combining different strategies, such as patient screening and intelligent vector design, gene therapy is set to make a difference in the life of patients with severe genetic diseases." @default.
- W4285742092 created "2022-07-18" @default.
- W4285742092 creator A5029825138 @default.
- W4285742092 creator A5032695747 @default.
- W4285742092 creator A5049129557 @default.
- W4285742092 creator A5065138381 @default.
- W4285742092 date "2022-01-01" @default.
- W4285742092 modified "2023-10-06" @default.
- W4285742092 title "Protection is not always a good thing: The immune system’s impact on gene therapy" @default.
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