Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285742362> ?p ?o ?g. }
- W4285742362 abstract "Mechanical allodynia (MA) is the main reason that patients with diabetic peripheral neuropathy (DPN) seek medical advice. It severely debilitates the quality of life. Investigating hyperglycemia-induced changes in neural transcription could provide fundamental insights into the complex pathogenesis of painful DPN (PDPN). Gene expression profiles of physiological dorsal root ganglia (DRG) have been studied. However, the transcriptomic changes in DRG neurons in PDPN remain largely unexplored. In this study, by single-cell RNA sequencing on dissociated rat DRG, we identified five physiological neuron types and a novel neuron type MAAC ( Fxyd7 + /Atp1b1 + ) in PDPN. The novel neuron type originated from peptidergic neuron cluster and was characterized by highly expressing genes related to neurofilament and cytoskeleton. Based on the inferred gene regulatory networks, we found that activated transcription factors Hobx7 and Larp1 in MAAC could enhance Atp1b1 expression. Moreover, we constructed the cellular communication network of MAAC and revealed its receptor-ligand pairs for transmitting signals with other cells. Our molecular investigation at single-cell resolution advances the understanding of the dynamic peripheral neuron changes and underlying molecular mechanisms during the development of PDPN." @default.
- W4285742362 created "2022-07-18" @default.
- W4285742362 creator A5009622796 @default.
- W4285742362 creator A5025639798 @default.
- W4285742362 creator A5027655104 @default.
- W4285742362 creator A5033253886 @default.
- W4285742362 creator A5040235858 @default.
- W4285742362 creator A5052565511 @default.
- W4285742362 creator A5087273468 @default.
- W4285742362 creator A5089681600 @default.
- W4285742362 date "2022-05-20" @default.
- W4285742362 modified "2023-10-11" @default.
- W4285742362 title "The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-Seq" @default.
- W4285742362 cites W1588482966 @default.
- W4285742362 cites W1645611860 @default.
- W4285742362 cites W1905377350 @default.
- W4285742362 cites W1959233553 @default.
- W4285742362 cites W1964571549 @default.
- W4285742362 cites W1984883254 @default.
- W4285742362 cites W1993384327 @default.
- W4285742362 cites W2003266871 @default.
- W4285742362 cites W2011411357 @default.
- W4285742362 cites W2018707257 @default.
- W4285742362 cites W2023305654 @default.
- W4285742362 cites W2024328449 @default.
- W4285742362 cites W2030665584 @default.
- W4285742362 cites W2033072655 @default.
- W4285742362 cites W2039341058 @default.
- W4285742362 cites W2061801043 @default.
- W4285742362 cites W2066104426 @default.
- W4285742362 cites W2084414551 @default.
- W4285742362 cites W2087395943 @default.
- W4285742362 cites W2103017472 @default.
- W4285742362 cites W2106406376 @default.
- W4285742362 cites W2126229620 @default.
- W4285742362 cites W2138207763 @default.
- W4285742362 cites W2138243502 @default.
- W4285742362 cites W2138754606 @default.
- W4285742362 cites W2142275367 @default.
- W4285742362 cites W2152877252 @default.
- W4285742362 cites W2154996842 @default.
- W4285742362 cites W2159675211 @default.
- W4285742362 cites W2166711075 @default.
- W4285742362 cites W2169456326 @default.
- W4285742362 cites W2172201406 @default.
- W4285742362 cites W2172395413 @default.
- W4285742362 cites W2196690866 @default.
- W4285742362 cites W2211603551 @default.
- W4285742362 cites W2286142055 @default.
- W4285742362 cites W2306460448 @default.
- W4285742362 cites W2394842952 @default.
- W4285742362 cites W2464201598 @default.
- W4285742362 cites W2475610676 @default.
- W4285742362 cites W2500444210 @default.
- W4285742362 cites W2581074366 @default.
- W4285742362 cites W2588505206 @default.
- W4285742362 cites W2597734448 @default.
- W4285742362 cites W2616922646 @default.
- W4285742362 cites W2740120239 @default.
- W4285742362 cites W2753084136 @default.
- W4285742362 cites W2762506555 @default.
- W4285742362 cites W2788398310 @default.
- W4285742362 cites W2887384837 @default.
- W4285742362 cites W2888547849 @default.
- W4285742362 cites W2890740349 @default.
- W4285742362 cites W2891841682 @default.
- W4285742362 cites W2901656544 @default.
- W4285742362 cites W2907514116 @default.
- W4285742362 cites W2912743928 @default.
- W4285742362 cites W2916719694 @default.
- W4285742362 cites W2922106290 @default.
- W4285742362 cites W2947524951 @default.
- W4285742362 cites W2951912016 @default.
- W4285742362 cites W2952734288 @default.
- W4285742362 cites W2979925777 @default.
- W4285742362 cites W3048656622 @default.
- W4285742362 cites W3078481672 @default.
- W4285742362 cites W3089751406 @default.
- W4285742362 cites W3132661792 @default.
- W4285742362 cites W3134557264 @default.
- W4285742362 cites W3135813546 @default.
- W4285742362 cites W3156537381 @default.
- W4285742362 cites W3164692211 @default.
- W4285742362 cites W4240924657 @default.
- W4285742362 cites W4292092457 @default.
- W4285742362 doi "https://doi.org/10.3389/fnmol.2022.856299" @default.
- W4285742362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35668789" @default.
- W4285742362 hasPublicationYear "2022" @default.
- W4285742362 type Work @default.
- W4285742362 citedByCount "6" @default.
- W4285742362 countsByYear W42857423622022 @default.
- W4285742362 countsByYear W42857423622023 @default.
- W4285742362 crossrefType "journal-article" @default.
- W4285742362 hasAuthorship W4285742362A5009622796 @default.
- W4285742362 hasAuthorship W4285742362A5025639798 @default.
- W4285742362 hasAuthorship W4285742362A5027655104 @default.
- W4285742362 hasAuthorship W4285742362A5033253886 @default.
- W4285742362 hasAuthorship W4285742362A5040235858 @default.
- W4285742362 hasAuthorship W4285742362A5052565511 @default.
- W4285742362 hasAuthorship W4285742362A5087273468 @default.