FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285797456> ?p ?o ?g. }

• W4285797456 abstract "Abstract Background The development of new targeted alpha therapies motivates improving alpha particle dosimetry. For alpha particles, microscopic targets must be considered to estimate dosimetric quantities that can predict the biological response. As double-strand breaks (DSB) on DNA are the main cause of cell death by ionizing radiation, cell nuclei are relevant volumes necessary to consider as targets. Since a large variance is expected of alpha particle hits in individual cell nuclei irradiated by an uncollimated alpha-emitting source, the damage induced should have a similar distribution. The induction of DSB can be measured by immunofluorescent γ-H2AX staining. The cell γ-H2AX foci distribution and alpha particle hits distribution should be comparable and thereby verify the necessity to consider the relevant dosimetric volumes. Methods A Monte Carlo simulation model of an 241 Am source alpha particle irradiation setup was combined with two versions of realistic cell nuclei phantoms. These were generated from DAPI-stained PC3 cells imaged with fluorescent microscopy, one consisting of elliptical cylinders and the other of segmented mesh volumes. PC3 cells were irradiated with the 241 Am source for 4, 8 and 12 min, and after 30 min fixated and stained with immunofluorescent γ-H2AX marker. The detected radiation-induced foci (RIF) were compared to simulated RIF. Results The mesh volume phantom detected a higher mean of alpha particle hits and energy imparted (MeV) per cell nuclei than the elliptical cylinder phantom, but the mean specific energy (Gy) was very similar. The mesh volume phantom detected a slightly larger variance between individual cells, stemming from the more extreme and less continuous distribution of cell nuclei sizes represented in this phantom. The simulated RIF distribution from both phantoms was in good agreement with the detected RIF, although the detected distribution had a zero-inflated shape not seen in the simulated distributions. An estimate of undetected foci was used to correct the detected RIF distribution and improved the agreement with the simulations. Conclusion Two methods to generate cell nuclei phantoms for Monte Carlo dosimetry simulations were tested and generated similar results. The simulated and detected RIF distributions from alpha particle-irradiated PC3 cells were in good agreement, proposing the necessity to consider microscopic targets in alpha particle dosimetry." @default.
• W4285797456 created "2022-07-19" @default.
• W4285797456 creator A5009201915 @default.
• W4285797456 creator A5046454862 @default.
• W4285797456 creator A5048071393 @default.
• W4285797456 creator A5064307945 @default.
• W4285797456 date "2022-07-19" @default.
• W4285797456 modified "2023-09-30" @default.
• W4285797456 title "Small-scale dosimetry for alpha particle 241Am source cell irradiation and estimation of γ-H2AX foci distribution in prostate cancer cell line PC3" @default.
• W4285797456 cites W1602963387 @default.
• W4285797456 cites W1977798765 @default.
• W4285797456 cites W1990182181 @default.
• W4285797456 cites W1994295113 @default.
• W4285797456 cites W2001399958 @default.
• W4285797456 cites W2002849978 @default.
• W4285797456 cites W2018649196 @default.
• W4285797456 cites W2077922140 @default.
• W4285797456 cites W2115750062 @default.
• W4285797456 cites W2141454098 @default.
• W4285797456 cites W2199048853 @default.
• W4285797456 cites W2212722493 @default.
• W4285797456 cites W2225135041 @default.
• W4285797456 cites W2253304324 @default.
• W4285797456 cites W2461265000 @default.
• W4285797456 cites W2467018059 @default.
• W4285797456 cites W2568078552 @default.
• W4285797456 cites W2568913147 @default.
• W4285797456 cites W2604062834 @default.
• W4285797456 cites W2752446957 @default.
• W4285797456 cites W2784080506 @default.
• W4285797456 cites W2807351458 @default.
• W4285797456 cites W2810406532 @default.
• W4285797456 cites W2891647981 @default.
• W4285797456 cites W2900455372 @default.
• W4285797456 cites W2941919759 @default.
• W4285797456 cites W2980321267 @default.
• W4285797456 cites W2995653709 @default.
• W4285797456 cites W3010430884 @default.
• W4285797456 cites W3022733984 @default.
• W4285797456 cites W3040382454 @default.
• W4285797456 cites W3090080894 @default.
• W4285797456 cites W3158974138 @default.
• W4285797456 cites W789874838 @default.
• W4285797456 doi "https://doi.org/10.1186/s40658-022-00475-x" @default.
• W4285797456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35852717" @default.
• W4285797456 hasPublicationYear "2022" @default.
• W4285797456 type Work @default.
• W4285797456 citedByCount "0" @default.
• W4285797456 crossrefType "journal-article" @default.
• W4285797456 hasAuthorship W4285797456A5009201915 @default.
• W4285797456 hasAuthorship W4285797456A5046454862 @default.
• W4285797456 hasAuthorship W4285797456A5048071393 @default.
• W4285797456 hasAuthorship W4285797456A5064307945 @default.
• W4285797456 hasBestOaLocation W42857974561 @default.
• W4285797456 hasConcept C104293457 @default.
• W4285797456 hasConcept C105795698 @default.
• W4285797456 hasConcept C111337013 @default.
• W4285797456 hasConcept C120665830 @default.
• W4285797456 hasConcept C121332964 @default.
• W4285797456 hasConcept C136229726 @default.
• W4285797456 hasConcept C151337348 @default.
• W4285797456 hasConcept C18231593 @default.
• W4285797456 hasConcept C184779094 @default.
• W4285797456 hasConcept C185544564 @default.
• W4285797456 hasConcept C18903297 @default.
• W4285797456 hasConcept C192562407 @default.
• W4285797456 hasConcept C19499675 @default.
• W4285797456 hasConcept C2778517922 @default.
• W4285797456 hasConcept C2989005 @default.
• W4285797456 hasConcept C33923547 @default.
• W4285797456 hasConcept C66385817 @default.
• W4285797456 hasConcept C71924100 @default.
• W4285797456 hasConcept C75088862 @default.
• W4285797456 hasConcept C86803240 @default.
• W4285797456 hasConceptScore W4285797456C104293457 @default.
• W4285797456 hasConceptScore W4285797456C105795698 @default.
• W4285797456 hasConceptScore W4285797456C111337013 @default.
• W4285797456 hasConceptScore W4285797456C120665830 @default.
• W4285797456 hasConceptScore W4285797456C121332964 @default.
• W4285797456 hasConceptScore W4285797456C136229726 @default.
• W4285797456 hasConceptScore W4285797456C151337348 @default.
• W4285797456 hasConceptScore W4285797456C18231593 @default.
• W4285797456 hasConceptScore W4285797456C184779094 @default.
• W4285797456 hasConceptScore W4285797456C185544564 @default.
• W4285797456 hasConceptScore W4285797456C18903297 @default.
• W4285797456 hasConceptScore W4285797456C192562407 @default.
• W4285797456 hasConceptScore W4285797456C19499675 @default.
• W4285797456 hasConceptScore W4285797456C2778517922 @default.
• W4285797456 hasConceptScore W4285797456C2989005 @default.
• W4285797456 hasConceptScore W4285797456C33923547 @default.
• W4285797456 hasConceptScore W4285797456C66385817 @default.
• W4285797456 hasConceptScore W4285797456C71924100 @default.
• W4285797456 hasConceptScore W4285797456C75088862 @default.
• W4285797456 hasConceptScore W4285797456C86803240 @default.
• W4285797456 hasFunder F4320321491 @default.
• W4285797456 hasFunder F4320321806 @default.
• W4285797456 hasFunder F4320322790 @default.
• W4285797456 hasIssue "1" @default.
• W4285797456 hasLocation W42857974561 @default.
• W4285797456 hasLocation W42857974562 @default.

• next