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- W4285797478 abstract "Cell regenerative therapy is a modern solution for difficult-to-heal wounds. Keratinocytes, the most common cell type in the skin, are difficult to obtain without the creation of another wound. Stem cell differentiation towards keratinocytes is a challenging process, and it is difficult to reproduce in chemically defined media. Nevertheless, a co-culture of keratinocytes with stem cells usually achieves efficient differentiation. This systematic review aims to identify the secretions of normal human keratinocytes reported in the literature and correlate them with the differentiation process. An online search revealed 338 references, of which 100 met the selection criteria. A total of 80 different keratinocyte secretions were reported, which can be grouped mainly into cytokines, growth factors, and antimicrobial peptides. The growth-factor group mostly affects stem cell differentiation into keratinocytes, especially epidermal growth factor and members of the transforming growth factor family. Nevertheless, the reported secretions reflected the nature of the involved studies, as most of them focused on keratinocyte interaction with inflammation. This review highlights the secretory function of keratinocytes, as well as the need for intense investigation to characterize these secretions and evaluate their regenerative capacities." @default.
- W4285797478 created "2022-07-19" @default.
- W4285797478 creator A5006341659 @default.
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- W4285797478 creator A5055460006 @default.
- W4285797478 creator A5060972860 @default.
- W4285797478 creator A5067987540 @default.
- W4285797478 date "2022-07-19" @default.
- W4285797478 modified "2023-10-01" @default.
- W4285797478 title "A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective" @default.
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