Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285798917> ?p ?o ?g. }
- W4285798917 abstract "Infants developing necrotizing enterocolitis (NEC) have a different metabolomic profile compared to controls. The potential of specific metabolomics, i.e. amino acids and amino alcohols (AAA), as early diagnostic biomarkers for NEC is largely unexplored. In this multicenter prospective case-control study, longitudinally collected fecal samples from preterm infants (born <30 weeks of gestation) from 1-3 days before diagnosis of severe NEC (Bell's stage IIIA/IIIB), were analyzed by targeted high-performance liquid chromatography (HPLC). Control samples were collected from gestational and postnatal age-matched infants. Thirty-one NEC cases (15 NEC IIIA;16 NEC IIIB) with 1:1 matched controls were included. Preclinical samples of infants with NEC were characterized by five increased essential amino acids-isoleucine, leucine, methionine, phenylalanine and valine. Lysine and ethanolamine ratios were lower prior to NEC, compared to control samples. A multivariate model was rendered based on isoleucine, lysine, ethanolamine, tryptophan and ornithine, modestly discriminating cases from controls (AUC 0.67; p < 0.001). Targeted HPLC pointed to several specific AAA alterations in samples collected 1-3 days before NEC onset, compared to controls. Whether this reflects metabolic alterations and has a role in early biomarker development for NEC, has yet to be elucidated." @default.
- W4285798917 created "2022-07-19" @default.
- W4285798917 creator A5008148334 @default.
- W4285798917 creator A5015259088 @default.
- W4285798917 creator A5019576860 @default.
- W4285798917 creator A5025463978 @default.
- W4285798917 creator A5026257121 @default.
- W4285798917 creator A5027940792 @default.
- W4285798917 creator A5028081239 @default.
- W4285798917 creator A5036462844 @default.
- W4285798917 creator A5042964493 @default.
- W4285798917 creator A5050981112 @default.
- W4285798917 creator A5051628638 @default.
- W4285798917 creator A5052358398 @default.
- W4285798917 creator A5058228324 @default.
- W4285798917 creator A5087989651 @default.
- W4285798917 creator A5089129794 @default.
- W4285798917 creator A5089325768 @default.
- W4285798917 creator A5089442654 @default.
- W4285798917 creator A5089682843 @default.
- W4285798917 date "2022-07-19" @default.
- W4285798917 modified "2023-09-30" @default.
- W4285798917 title "Fecal amine metabolite analysis before onset of severe necrotizing enterocolitis in preterm infants: a prospective case–control study" @default.
- W4285798917 cites W1569631496 @default.
- W4285798917 cites W1802132637 @default.
- W4285798917 cites W1964043348 @default.
- W4285798917 cites W1989647615 @default.
- W4285798917 cites W1990422104 @default.
- W4285798917 cites W2015540485 @default.
- W4285798917 cites W2018810173 @default.
- W4285798917 cites W2034519657 @default.
- W4285798917 cites W2037990526 @default.
- W4285798917 cites W2038168279 @default.
- W4285798917 cites W2039698305 @default.
- W4285798917 cites W2072813242 @default.
- W4285798917 cites W2129783473 @default.
- W4285798917 cites W2168150136 @default.
- W4285798917 cites W2301034803 @default.
- W4285798917 cites W2328370969 @default.
- W4285798917 cites W2350379238 @default.
- W4285798917 cites W2574079157 @default.
- W4285798917 cites W2589687870 @default.
- W4285798917 cites W2617696743 @default.
- W4285798917 cites W2731955755 @default.
- W4285798917 cites W2765566796 @default.
- W4285798917 cites W2772606302 @default.
- W4285798917 cites W2793033675 @default.
- W4285798917 cites W2795579070 @default.
- W4285798917 cites W2809515090 @default.
- W4285798917 cites W2883693532 @default.
- W4285798917 cites W2886547861 @default.
- W4285798917 cites W2886985529 @default.
- W4285798917 cites W2887762792 @default.
- W4285798917 cites W2888401908 @default.
- W4285798917 cites W2892056324 @default.
- W4285798917 cites W2902079562 @default.
- W4285798917 cites W2903707086 @default.
- W4285798917 cites W2936180285 @default.
- W4285798917 cites W2938535690 @default.
- W4285798917 cites W2944442511 @default.
- W4285798917 cites W2946362234 @default.
- W4285798917 cites W2996486822 @default.
- W4285798917 cites W2999597222 @default.
- W4285798917 cites W3001856178 @default.
- W4285798917 cites W3027318708 @default.
- W4285798917 cites W3113213386 @default.
- W4285798917 cites W3176026299 @default.
- W4285798917 cites W2091311856 @default.
- W4285798917 doi "https://doi.org/10.1038/s41598-022-16351-8" @default.
- W4285798917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35853977" @default.
- W4285798917 hasPublicationYear "2022" @default.
- W4285798917 type Work @default.
- W4285798917 citedByCount "1" @default.
- W4285798917 countsByYear W42857989172023 @default.
- W4285798917 crossrefType "journal-article" @default.
- W4285798917 hasAuthorship W4285798917A5008148334 @default.
- W4285798917 hasAuthorship W4285798917A5015259088 @default.
- W4285798917 hasAuthorship W4285798917A5019576860 @default.
- W4285798917 hasAuthorship W4285798917A5025463978 @default.
- W4285798917 hasAuthorship W4285798917A5026257121 @default.
- W4285798917 hasAuthorship W4285798917A5027940792 @default.
- W4285798917 hasAuthorship W4285798917A5028081239 @default.
- W4285798917 hasAuthorship W4285798917A5036462844 @default.
- W4285798917 hasAuthorship W4285798917A5042964493 @default.
- W4285798917 hasAuthorship W4285798917A5050981112 @default.
- W4285798917 hasAuthorship W4285798917A5051628638 @default.
- W4285798917 hasAuthorship W4285798917A5052358398 @default.
- W4285798917 hasAuthorship W4285798917A5058228324 @default.
- W4285798917 hasAuthorship W4285798917A5087989651 @default.
- W4285798917 hasAuthorship W4285798917A5089129794 @default.
- W4285798917 hasAuthorship W4285798917A5089325768 @default.
- W4285798917 hasAuthorship W4285798917A5089442654 @default.
- W4285798917 hasAuthorship W4285798917A5089682843 @default.
- W4285798917 hasBestOaLocation W42857989171 @default.
- W4285798917 hasConcept C126322002 @default.
- W4285798917 hasConcept C188816634 @default.
- W4285798917 hasConcept C2776580952 @default.
- W4285798917 hasConcept C2776796294 @default.
- W4285798917 hasConcept C2777305461 @default.
- W4285798917 hasConcept C2777468819 @default.