Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285801723> ?p ?o ?g. }
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- W4285801723 abstract "The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic, antioxidant, anti-inflammatory and P-gp inhibitor for enhancing bioavailability and to obtain synergistic anti-cancer effect against breast cancer. SNEDDS were developed using capmul MCM as oil, Tween 80 as surfactant and transcutol-HP as co-surfactant and optimized by central composite rotatable design. Neusilin US2 concentration was optimized for adsorption of liquid SNEDDS to prepare s-SNEDDS. The developed formulation was characterized and investigated for various in vitro and cell line comparative studies. Optimized TAM-RES-s-SNEDDS showed spherical droplets of a size less than 200 nm. In all in vitro studies, TAM-RES-s-SNEDDS showed significantly improved (p ˂ 0.05) release and permeation across the dialysis membrane and intestinal lumen. Moreover, TAM-RES-s-SNEDDS possessed significantly greater therapeutic efficacy (p < 0.05) and better internalization on the MCF-7 cell line as compared to the conventional formulation. Additionally, oral bioavailability of TAM from SNEDDS was 1.63 folds significantly higher (p < 0.05) than that of combination suspension and 4.16 folds significantly higher (p < 0.05) than TAM suspension. Thus, findings suggest that TAM- RES-s-SNEDDS can be the future delivery system that potentially delivers both drugs to cancer cells for better treatment." @default.
- W4285801723 created "2022-07-19" @default.
- W4285801723 creator A5022894865 @default.
- W4285801723 creator A5025737605 @default.
- W4285801723 creator A5026486245 @default.
- W4285801723 creator A5030760432 @default.
- W4285801723 creator A5049495987 @default.
- W4285801723 creator A5049947030 @default.
- W4285801723 creator A5065750369 @default.
- W4285801723 creator A5080857013 @default.
- W4285801723 creator A5084946200 @default.
- W4285801723 date "2022-07-18" @default.
- W4285801723 modified "2023-10-05" @default.
- W4285801723 title "Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer" @default.
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