FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285801850> ?p ?o ?g. }

• W4285801850 endingPage "915" @default.
• W4285801850 startingPage "915" @default.
• W4285801850 abstract "<h3>Importance</h3> Presence of developmental delays in autism is well established, yet few studies have characterized variability in developmental milestone attainment in this population. <h3>Objective</h3> To characterize variability in the age at which autistic individuals attain key developmental milestones based on co-occurring intellectual disability (ID), presence of a rare disruptive genetic variant associated with neurodevelopmental disorders (NDD), age at autism diagnosis, and research cohort membership. <h3>Design</h3> The study team harmonized data from 4 cross-sectional autism cohorts: the Autism Genetics Research Exchange (n = 3284; 1997-2015), The Autism Simplex Collection (n = 694; 2008-2011), the Simons Simplex Collection (n = 2753; 2008-2011), and the Simons Foundation Powering Autism Research for Knowledge (n = 10 367; 2016-present). The last sample further included 4145 siblings without an autism diagnosis or ID. <h3>Participants</h3> Convenience sample of 21 243 autistic individuals or their siblings without an autism diagnosis aged 4 to 17 years. <h3>Main Outcomes and Measures</h3> Parents reported ages at which participants attained key milestones including smiling, sitting upright, crawling, walking, spoon-feeding self, speaking words, speaking phrases, and acquiring bladder and bowel control. A total of 5295 autistic individuals, and their biological parents, were genetically characterized to identify de novo variants in NDD-associated genes. The study team conducted time-to-event analyses to estimate and compare percentiles in time with milestone attainment across autistic individuals, subgroups of autistic individuals, and the sibling sample. <h3>Results</h3> Seventeen thousand ninety-eight autistic individuals (mean age, 9.15 years; 80.8% male) compared with 4145 siblings without autism or ID (mean age, 10.2 years; 50.2% female) showed delays in milestone attainment, with median (IQR) delays ranging from 0.7 (0.3-1.6) to 19.7 (11.4-32.2) months. More severe and more variable delays in autism were associated with the presence of co-occurring ID, carrying an NDD-associated rare genetic variant, and being diagnosed with autism by age 5 years. More severe and more variable delays were also associated with membership in earlier study cohorts, consistent with autism’s diagnostic and ascertainment expansion over the last 30 years. <h3>Conclusions and Relevance</h3> As the largest summary to date of developmental milestone attainment in autism, to our knowledge, this study demonstrates substantial developmental variability across different conditions and provides important context for understanding the phenotypic and etiological heterogeneity of autism." @default.
• W4285801850 created "2022-07-19" @default.
• W4285801850 creator A5002303468 @default.
• W4285801850 creator A5018364849 @default.
• W4285801850 creator A5039423400 @default.
• W4285801850 creator A5059184433 @default.
• W4285801850 creator A5060291693 @default.
• W4285801850 creator A5067226360 @default.
• W4285801850 creator A5077615112 @default.
• W4285801850 date "2022-09-01" @default.
• W4285801850 modified "2023-10-05" @default.
• W4285801850 title "Developmental Variability in Autism Across 17 000 Autistic Individuals and 4000 Siblings Without an Autism Diagnosis" @default.
• W4285801850 cites W1549109732 @default.
• W4285801850 cites W1596515083 @default.
• W4285801850 cites W1880416213 @default.
• W4285801850 cites W1903167465 @default.
• W4285801850 cites W1976197617 @default.
• W4285801850 cites W1978140034 @default.
• W4285801850 cites W2008627757 @default.
• W4285801850 cites W2033021653 @default.
• W4285801850 cites W2048517170 @default.
• W4285801850 cites W2062328738 @default.
• W4285801850 cites W2070034706 @default.
• W4285801850 cites W2074099509 @default.
• W4285801850 cites W2080373387 @default.
• W4285801850 cites W2082036307 @default.
• W4285801850 cites W2084885420 @default.
• W4285801850 cites W2094623935 @default.
• W4285801850 cites W2118574816 @default.
• W4285801850 cites W2120017555 @default.
• W4285801850 cites W2122163116 @default.
• W4285801850 cites W2129844670 @default.
• W4285801850 cites W2135032122 @default.
• W4285801850 cites W2139525474 @default.
• W4285801850 cites W2142635246 @default.
• W4285801850 cites W2159197552 @default.
• W4285801850 cites W2275737843 @default.
• W4285801850 cites W2282690096 @default.
• W4285801850 cites W2318996262 @default.
• W4285801850 cites W2592553489 @default.
• W4285801850 cites W2604697269 @default.
• W4285801850 cites W2625862723 @default.
• W4285801850 cites W2767648131 @default.
• W4285801850 cites W2785900161 @default.
• W4285801850 cites W2806934123 @default.
• W4285801850 cites W2902200636 @default.
• W4285801850 cites W2927010782 @default.
• W4285801850 cites W2954258230 @default.
• W4285801850 cites W2955503846 @default.
• W4285801850 cites W2984581630 @default.
• W4285801850 cites W3024199257 @default.
• W4285801850 cites W3093292403 @default.
• W4285801850 cites W3099367322 @default.
• W4285801850 cites W3162021500 @default.
• W4285801850 cites W3204469225 @default.
• W4285801850 cites W3216151710 @default.
• W4285801850 cites W4200619411 @default.
• W4285801850 cites W4229838445 @default.
• W4285801850 cites W4237250872 @default.
• W4285801850 cites W4240268771 @default.
• W4285801850 cites W4244921826 @default.
• W4285801850 cites W4248215124 @default.
• W4285801850 cites W4249154079 @default.
• W4285801850 doi "https://doi.org/10.1001/jamapediatrics.2022.2423" @default.
• W4285801850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35849387" @default.
• W4285801850 hasPublicationYear "2022" @default.
• W4285801850 type Work @default.
• W4285801850 citedByCount "7" @default.
• W4285801850 countsByYear W42858018502022 @default.
• W4285801850 countsByYear W42858018502023 @default.
• W4285801850 crossrefType "journal-article" @default.
• W4285801850 hasAuthorship W4285801850A5002303468 @default.
• W4285801850 hasAuthorship W4285801850A5018364849 @default.
• W4285801850 hasAuthorship W4285801850A5039423400 @default.
• W4285801850 hasAuthorship W4285801850A5059184433 @default.
• W4285801850 hasAuthorship W4285801850A5060291693 @default.
• W4285801850 hasAuthorship W4285801850A5067226360 @default.
• W4285801850 hasAuthorship W4285801850A5077615112 @default.
• W4285801850 hasBestOaLocation W42858018501 @default.
• W4285801850 hasConcept C118552586 @default.
• W4285801850 hasConcept C120060458 @default.
• W4285801850 hasConcept C126322002 @default.
• W4285801850 hasConcept C138496976 @default.
• W4285801850 hasConcept C15744967 @default.
• W4285801850 hasConcept C166957645 @default.
• W4285801850 hasConcept C187212893 @default.
• W4285801850 hasConcept C205778803 @default.
• W4285801850 hasConcept C2778594975 @default.
• W4285801850 hasConcept C2908647359 @default.
• W4285801850 hasConcept C2909830880 @default.
• W4285801850 hasConcept C551499885 @default.
• W4285801850 hasConcept C70410870 @default.
• W4285801850 hasConcept C71924100 @default.
• W4285801850 hasConcept C72563966 @default.
• W4285801850 hasConcept C95457728 @default.
• W4285801850 hasConcept C99454951 @default.
• W4285801850 hasConceptScore W4285801850C118552586 @default.
• W4285801850 hasConceptScore W4285801850C120060458 @default.

• next