Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285802258> ?p ?o ?g. }
- W4285802258 endingPage "3486" @default.
- W4285802258 startingPage "3486" @default.
- W4285802258 abstract "Cancer-associated fibroblasts (CAFs) reside within the tumor microenvironment, facilitating cancer progression and metastasis via direct and indirect interactions with cancer cells and other stromal cell types. CAFs are composed of heterogeneous subpopulations of activated fibroblasts, including myofibroblastic, inflammatory, and immunosuppressive CAFs. In this study, we sought to identify subpopulations of CAFs isolated from human lung adenocarcinomas and describe their transcriptomic and functional characteristics through single-cell RNA sequencing (scRNA-seq) and subsequent bioinformatics analyses. Cell trajectory analysis of combined total and THY1 + CAFs revealed two branching points with five distinct branches. Based on Gene Ontology analysis, we denoted Branch 1 as “immunosuppressive”, Branch 2 as “neoantigen presenting”, Branch 4 as “myofibroblastic”, and Branch 5 as “proliferative” CAFs. We selected representative branch-specific markers and measured their expression levels in total and THY1 + CAFs. We also investigated the effects of these markers on CAF activity under coculture with lung cancer cells. This study describes novel subpopulations of CAFs in lung adenocarcinoma, highlighting their potential value as therapeutic targets." @default.
- W4285802258 created "2022-07-19" @default.
- W4285802258 creator A5003463853 @default.
- W4285802258 creator A5003719092 @default.
- W4285802258 creator A5009049568 @default.
- W4285802258 creator A5031083361 @default.
- W4285802258 creator A5035847757 @default.
- W4285802258 creator A5047095759 @default.
- W4285802258 creator A5055800505 @default.
- W4285802258 creator A5062061036 @default.
- W4285802258 creator A5069309146 @default.
- W4285802258 creator A5071755447 @default.
- W4285802258 creator A5076585994 @default.
- W4285802258 creator A5078369678 @default.
- W4285802258 creator A5082511680 @default.
- W4285802258 date "2022-07-18" @default.
- W4285802258 modified "2023-10-15" @default.
- W4285802258 title "Identification and Characterization of Cancer-Associated Fibroblast Subpopulations in Lung Adenocarcinoma" @default.
- W4285802258 cites W1200678608 @default.
- W4285802258 cites W1890349608 @default.
- W4285802258 cites W1999574084 @default.
- W4285802258 cites W2001024793 @default.
- W4285802258 cites W2003762242 @default.
- W4285802258 cites W2069399470 @default.
- W4285802258 cites W2074891103 @default.
- W4285802258 cites W2108231528 @default.
- W4285802258 cites W2123242217 @default.
- W4285802258 cites W2126882378 @default.
- W4285802258 cites W2131271579 @default.
- W4285802258 cites W2150881491 @default.
- W4285802258 cites W2169456326 @default.
- W4285802258 cites W2184867100 @default.
- W4285802258 cites W2266287744 @default.
- W4285802258 cites W2331825045 @default.
- W4285802258 cites W2332030302 @default.
- W4285802258 cites W2523216894 @default.
- W4285802258 cites W2582033455 @default.
- W4285802258 cites W2649656222 @default.
- W4285802258 cites W2736521070 @default.
- W4285802258 cites W2738330632 @default.
- W4285802258 cites W2767281692 @default.
- W4285802258 cites W2771542157 @default.
- W4285802258 cites W2778974161 @default.
- W4285802258 cites W2790543400 @default.
- W4285802258 cites W2794480084 @default.
- W4285802258 cites W2799908276 @default.
- W4285802258 cites W2865352686 @default.
- W4285802258 cites W2887149328 @default.
- W4285802258 cites W2898471127 @default.
- W4285802258 cites W2902447942 @default.
- W4285802258 cites W2911883556 @default.
- W4285802258 cites W2917766674 @default.
- W4285802258 cites W2921665198 @default.
- W4285802258 cites W2941384888 @default.
- W4285802258 cites W2944545583 @default.
- W4285802258 cites W2949237386 @default.
- W4285802258 cites W2951071083 @default.
- W4285802258 cites W2951222857 @default.
- W4285802258 cites W2954890254 @default.
- W4285802258 cites W2961869653 @default.
- W4285802258 cites W2962704087 @default.
- W4285802258 cites W2966710588 @default.
- W4285802258 cites W2970289072 @default.
- W4285802258 cites W2985644141 @default.
- W4285802258 cites W2986162201 @default.
- W4285802258 cites W2994565852 @default.
- W4285802258 cites W3003058300 @default.
- W4285802258 cites W3009370296 @default.
- W4285802258 cites W3022968840 @default.
- W4285802258 cites W3026844837 @default.
- W4285802258 cites W3043246820 @default.
- W4285802258 cites W3092471248 @default.
- W4285802258 cites W3092537029 @default.
- W4285802258 cites W3110893055 @default.
- W4285802258 cites W3128646645 @default.
- W4285802258 cites W3143016204 @default.
- W4285802258 cites W3165395145 @default.
- W4285802258 cites W3174631073 @default.
- W4285802258 cites W3185046562 @default.
- W4285802258 doi "https://doi.org/10.3390/cancers14143486" @default.
- W4285802258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35884546" @default.
- W4285802258 hasPublicationYear "2022" @default.
- W4285802258 type Work @default.
- W4285802258 citedByCount "5" @default.
- W4285802258 countsByYear W42858022582022 @default.
- W4285802258 countsByYear W42858022582023 @default.
- W4285802258 crossrefType "journal-article" @default.
- W4285802258 hasAuthorship W4285802258A5003463853 @default.
- W4285802258 hasAuthorship W4285802258A5003719092 @default.
- W4285802258 hasAuthorship W4285802258A5009049568 @default.
- W4285802258 hasAuthorship W4285802258A5031083361 @default.
- W4285802258 hasAuthorship W4285802258A5035847757 @default.
- W4285802258 hasAuthorship W4285802258A5047095759 @default.
- W4285802258 hasAuthorship W4285802258A5055800505 @default.
- W4285802258 hasAuthorship W4285802258A5062061036 @default.
- W4285802258 hasAuthorship W4285802258A5069309146 @default.
- W4285802258 hasAuthorship W4285802258A5071755447 @default.
- W4285802258 hasAuthorship W4285802258A5076585994 @default.