Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285803033> ?p ?o ?g. }
- W4285803033 endingPage "1733" @default.
- W4285803033 startingPage "1733" @default.
- W4285803033 abstract "Intra-articular injections of glucocorticoids (GC) or hyaluronic acid (HA) are commonly used interventions for patients suffering from knee osteoarthritis (OA). Both substances are combined to achieve a chondroprotective and anti-inflammatory effect. Clinical studies have shown benefits, but data on the cellular level are still lacking. This study aimed to investigate the effect of the GC triamcinolone hexacetonide, HA, and a mix of both substances on cytokine-treated chondrocytes in vitro. Chondrocytes isolated from human articular cartilage were seeded on 6- and 24-well plates. Mimicking OA's inflammatory state, cells were treated with IL-1β and IL-17 for six days, whereby, after three days, test substances (10%) were added to the culture medium. Chondrocytes were analyzed on days three and six concerning their actin polymerization, expression of anabolic and catabolic genes, metabolic activity, cytokine release, and reactive oxygen species (ROS). Adding HA or GC/HA to the inflammatory culture medium increased the metabolic activity of chondrocytes, while groups containing GC reduced catabolic gene expression and the release of TNF-α. In addition, enhanced F-actin content was shown supplementing HA or GC/HA to the culture medium. Supplementing GC with HA leads to an anti-inflammatory and chondroprotective effect by diminishing the side effects of GC supplementation alone." @default.
- W4285803033 created "2022-07-19" @default.
- W4285803033 creator A5005484603 @default.
- W4285803033 creator A5033903010 @default.
- W4285803033 creator A5044319769 @default.
- W4285803033 creator A5076546970 @default.
- W4285803033 creator A5084865407 @default.
- W4285803033 creator A5088359955 @default.
- W4285803033 date "2022-07-18" @default.
- W4285803033 modified "2023-10-03" @default.
- W4285803033 title "Increased Chondroprotective Effect of Combining Hyaluronic Acid with a Glucocorticoid Compared to Separate Administration on Cytokine-Treated Osteoarthritic Chondrocytes in a 2D Culture" @default.
- W4285803033 cites W1501094962 @default.
- W4285803033 cites W1831989259 @default.
- W4285803033 cites W1858962647 @default.
- W4285803033 cites W1964375939 @default.
- W4285803033 cites W1967139262 @default.
- W4285803033 cites W1967269017 @default.
- W4285803033 cites W1967723563 @default.
- W4285803033 cites W1967811658 @default.
- W4285803033 cites W1978943323 @default.
- W4285803033 cites W1980755508 @default.
- W4285803033 cites W1984317348 @default.
- W4285803033 cites W1988861536 @default.
- W4285803033 cites W1990692609 @default.
- W4285803033 cites W1993990835 @default.
- W4285803033 cites W1997078828 @default.
- W4285803033 cites W2007452107 @default.
- W4285803033 cites W2015699079 @default.
- W4285803033 cites W2035972979 @default.
- W4285803033 cites W2037866214 @default.
- W4285803033 cites W2045683491 @default.
- W4285803033 cites W2051061580 @default.
- W4285803033 cites W2058394330 @default.
- W4285803033 cites W2061412466 @default.
- W4285803033 cites W2070265035 @default.
- W4285803033 cites W2082954333 @default.
- W4285803033 cites W2087363463 @default.
- W4285803033 cites W2090136414 @default.
- W4285803033 cites W2099285233 @default.
- W4285803033 cites W2107277218 @default.
- W4285803033 cites W2111110563 @default.
- W4285803033 cites W2113670619 @default.
- W4285803033 cites W2142472895 @default.
- W4285803033 cites W2144475884 @default.
- W4285803033 cites W2162435517 @default.
- W4285803033 cites W2164993228 @default.
- W4285803033 cites W2184933226 @default.
- W4285803033 cites W2192080449 @default.
- W4285803033 cites W2230785318 @default.
- W4285803033 cites W2235731915 @default.
- W4285803033 cites W2292034152 @default.
- W4285803033 cites W2471765685 @default.
- W4285803033 cites W2519760004 @default.
- W4285803033 cites W2574631460 @default.
- W4285803033 cites W2580619303 @default.
- W4285803033 cites W2584503597 @default.
- W4285803033 cites W2586415715 @default.
- W4285803033 cites W2619901099 @default.
- W4285803033 cites W2735527928 @default.
- W4285803033 cites W2801046945 @default.
- W4285803033 cites W2883609079 @default.
- W4285803033 cites W2952643930 @default.
- W4285803033 cites W2970975149 @default.
- W4285803033 cites W2979673331 @default.
- W4285803033 cites W3003035923 @default.
- W4285803033 cites W3160603068 @default.
- W4285803033 cites W3193501355 @default.
- W4285803033 cites W4200622488 @default.
- W4285803033 cites W4254025084 @default.
- W4285803033 doi "https://doi.org/10.3390/biomedicines10071733" @default.
- W4285803033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35885038" @default.
- W4285803033 hasPublicationYear "2022" @default.
- W4285803033 type Work @default.
- W4285803033 citedByCount "3" @default.
- W4285803033 countsByYear W42858030332022 @default.
- W4285803033 countsByYear W42858030332023 @default.
- W4285803033 crossrefType "journal-article" @default.
- W4285803033 hasAuthorship W4285803033A5005484603 @default.
- W4285803033 hasAuthorship W4285803033A5033903010 @default.
- W4285803033 hasAuthorship W4285803033A5044319769 @default.
- W4285803033 hasAuthorship W4285803033A5076546970 @default.
- W4285803033 hasAuthorship W4285803033A5084865407 @default.
- W4285803033 hasAuthorship W4285803033A5088359955 @default.
- W4285803033 hasBestOaLocation W42858030331 @default.
- W4285803033 hasConcept C1008401 @default.
- W4285803033 hasConcept C105702510 @default.
- W4285803033 hasConcept C142724271 @default.
- W4285803033 hasConcept C185592680 @default.
- W4285803033 hasConcept C202751555 @default.
- W4285803033 hasConcept C203014093 @default.
- W4285803033 hasConcept C204787440 @default.
- W4285803033 hasConcept C2776164576 @default.
- W4285803033 hasConcept C2777529286 @default.
- W4285803033 hasConcept C2778690821 @default.
- W4285803033 hasConcept C2780550940 @default.
- W4285803033 hasConcept C2780841215 @default.
- W4285803033 hasConcept C55493867 @default.
- W4285803033 hasConcept C62231903 @default.