Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285803721> ?p ?o ?g. }
- W4285803721 abstract "The Arf GTPase family is involved in a wide range of cellular regulation including membrane trafficking and organelle-structure assembly. Here, we have generated a proximity interaction network for the Arf family using the miniTurboID approach combined with TMT-based quantitative mass spectrometry. Our interactome confirmed known interactions and identified many novel interactors that provide leads for defining Arf pathway cell biological functions. We explored the unexpected finding that phospholipase D1 (PLD1) preferentially interacts with two closely related but poorly studied Arf family GTPases, ARL11 and ARL14, showing that PLD1 is activated by ARL11/14 and may recruit these GTPases to membrane vesicles, and that PLD1 and ARL11 collaborate to promote macrophage phagocytosis. Moreover, ARL5A and ARL5B were found to interact with and recruit phosphatidylinositol 4-kinase beta (PI4KB) at trans-Golgi, thus promoting PI4KB's function in PI4P synthesis and protein secretion." @default.
- W4285803721 created "2022-07-19" @default.
- W4285803721 creator A5003681988 @default.
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- W4285803721 date "2022-07-17" @default.
- W4285803721 modified "2023-10-18" @default.
- W4285803721 title "Defining the proximal interaction networks of Arf <scp>GTPases</scp> reveals a mechanism for the regulation of <scp>PLD1</scp> and <scp>PI4KB</scp>" @default.
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- W4285803721 doi "https://doi.org/10.15252/embj.2022110698" @default.
- W4285803721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35844135" @default.
- W4285803721 hasPublicationYear "2022" @default.
- W4285803721 type Work @default.