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- W4285806210 endingPage "104787" @default.
- W4285806210 startingPage "104787" @default.
- W4285806210 abstract "Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple AML subtypes. One common factor across AML subtypes is the presence of a block in differentiation. Overcoming this block should allow for the identification of therapies that are not dependent on a specific mutation for their efficacy. Here, we used a phenotypic screen to identify compounds that stimulate differentiation in genetically diverse AML cell lines. Lead compounds were shown to decrease tumor burden and to increase survival in vivo. Using multiple complementary target deconvolution approaches, these compounds were revealed to be anti-mitotic tubulin disruptors that cause differentiation by inducing a G2-M mitotic arrest. Together, these results reveal a function for tubulin disruptors in causing differentiation of AML cells." @default.
- W4285806210 created "2022-07-19" @default.
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- W4285806210 date "2022-08-01" @default.
- W4285806210 modified "2023-09-24" @default.
- W4285806210 title "A tubulin binding molecule drives differentiation of acute myeloid leukemia cells" @default.
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