Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285806737> ?p ?o ?g. }
- W4285806737 endingPage "104771" @default.
- W4285806737 startingPage "104771" @default.
- W4285806737 abstract "Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets the pancreas. Here, we employ bromocriptine as a tool to elucidate the roles of catecholamine signaling in regulating pancreatic hormone secretion. In β-cells, bromocriptine acts on D2R and α2A-adrenergic receptor (α2A-AR) to reduce glucose-stimulated insulin secretion (GSIS). Moreover, in α-cells, bromocriptine acts via D2R to reduce glucagon secretion. α2A-AR activation by bromocriptine recruits an ensemble of G proteins with no β-arrestin2 recruitment. In contrast, D2R recruits G proteins and β-arrestin2 upon bromocriptine stimulation, demonstrating receptor-specific signaling. Docking studies reveal distinct bromocriptine binding to α2A-AR versus D2R, providing a structural basis for bromocriptine’s dual actions on β-cell α2A-AR and D2R. Together, joint dopaminergic and adrenergic receptor actions on α-cell and β-cell hormone release provide a new therapeutic mechanism to improve dysglycemia." @default.
- W4285806737 created "2022-07-19" @default.
- W4285806737 creator A5002297958 @default.
- W4285806737 creator A5013792187 @default.
- W4285806737 creator A5022343281 @default.
- W4285806737 creator A5025842562 @default.
- W4285806737 creator A5034202004 @default.
- W4285806737 creator A5040292972 @default.
- W4285806737 creator A5041804176 @default.
- W4285806737 creator A5042873368 @default.
- W4285806737 creator A5053200897 @default.
- W4285806737 creator A5056446196 @default.
- W4285806737 creator A5057969622 @default.
- W4285806737 creator A5063384054 @default.
- W4285806737 creator A5069927019 @default.
- W4285806737 creator A5072771208 @default.
- W4285806737 creator A5076880355 @default.
- W4285806737 date "2022-08-01" @default.
- W4285806737 modified "2023-09-30" @default.
- W4285806737 title "Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine" @default.
- W4285806737 cites W1507887256 @default.
- W4285806737 cites W1544363839 @default.
- W4285806737 cites W1565257873 @default.
- W4285806737 cites W1786514222 @default.
- W4285806737 cites W1909895122 @default.
- W4285806737 cites W1932064022 @default.
- W4285806737 cites W1959679999 @default.
- W4285806737 cites W1967612416 @default.
- W4285806737 cites W1972562997 @default.
- W4285806737 cites W1973974623 @default.
- W4285806737 cites W1975664737 @default.
- W4285806737 cites W1977862375 @default.
- W4285806737 cites W1983330821 @default.
- W4285806737 cites W1986092886 @default.
- W4285806737 cites W1986935249 @default.
- W4285806737 cites W1987350568 @default.
- W4285806737 cites W1987735363 @default.
- W4285806737 cites W1989850958 @default.
- W4285806737 cites W1990950002 @default.
- W4285806737 cites W1991721039 @default.
- W4285806737 cites W1998568262 @default.
- W4285806737 cites W2001447612 @default.
- W4285806737 cites W2002249936 @default.
- W4285806737 cites W2005082727 @default.
- W4285806737 cites W2012738439 @default.
- W4285806737 cites W2020260928 @default.
- W4285806737 cites W2027389034 @default.
- W4285806737 cites W2029505402 @default.
- W4285806737 cites W2030670787 @default.
- W4285806737 cites W2031057942 @default.
- W4285806737 cites W2033927270 @default.
- W4285806737 cites W2036023624 @default.
- W4285806737 cites W2047967291 @default.
- W4285806737 cites W2048159519 @default.
- W4285806737 cites W2049764565 @default.
- W4285806737 cites W2049927057 @default.
- W4285806737 cites W2057952370 @default.
- W4285806737 cites W2061481034 @default.
- W4285806737 cites W2065127510 @default.
- W4285806737 cites W2066583605 @default.
- W4285806737 cites W2074631079 @default.
- W4285806737 cites W2076100881 @default.
- W4285806737 cites W2080580057 @default.
- W4285806737 cites W2087968790 @default.
- W4285806737 cites W2089560759 @default.
- W4285806737 cites W2089919712 @default.
- W4285806737 cites W2095374622 @default.
- W4285806737 cites W2097744565 @default.
- W4285806737 cites W2103994532 @default.
- W4285806737 cites W2107582181 @default.
- W4285806737 cites W2113905390 @default.
- W4285806737 cites W2120358730 @default.
- W4285806737 cites W2122104686 @default.
- W4285806737 cites W2126132542 @default.
- W4285806737 cites W2130358596 @default.
- W4285806737 cites W2133147215 @default.
- W4285806737 cites W2133608824 @default.
- W4285806737 cites W2140402299 @default.
- W4285806737 cites W2140864873 @default.
- W4285806737 cites W2144035284 @default.
- W4285806737 cites W2144228386 @default.
- W4285806737 cites W2145094745 @default.
- W4285806737 cites W2152903006 @default.
- W4285806737 cites W2155941934 @default.
- W4285806737 cites W2158187739 @default.
- W4285806737 cites W2159388107 @default.
- W4285806737 cites W2166977877 @default.
- W4285806737 cites W2168954492 @default.
- W4285806737 cites W2169274492 @default.
- W4285806737 cites W2196957770 @default.
- W4285806737 cites W2209250985 @default.
- W4285806737 cites W2213830934 @default.
- W4285806737 cites W2230681148 @default.
- W4285806737 cites W2271472870 @default.
- W4285806737 cites W2291516670 @default.
- W4285806737 cites W2333990294 @default.
- W4285806737 cites W2334709822 @default.
- W4285806737 cites W2346521219 @default.