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• W4285808110 abstract "Parallel transmission (pTx) is an approach to improve image uniformity for ultra-high field imaging. In this study, we modified an echo planar imaging (EPI) sequence to design subject-specific pTx pulses online. We compared its performance against EPI with conventional circularly polarised (CP) pulses. We compared the pTx-EPI and CP-EPI sequences in a short EPI acquisition protocol and for two different functional paradigms in six healthy volunteers (2 female, aged 23–36 years, mean age 29.2 years). We chose two paradigms that are typically affected by signal dropout at 7 T: a visual objects localiser to determine face/scene selective brain regions and a semantic-processing task. Across all subjects, pTx-EPI improved whole-brain mean temporal signal-to-noise ratio (tSNR) by 11.0% compared to CP-EPI. We also compared the ability of pTx-EPI and CP-EPI to detect functional activation for three contrasts over the two paradigms: face > object and scene > object for the visual objects localiser and semantic association > pattern matching for the semantic-processing paradigm. Across all three contrasts, pTx-EPI showed higher median z-scores and detected more active voxels in relevant areas, as determined from previous 3 T studies. We have demonstrated a workflow for EPI acquisitions with online per-subject pulse calculations. We saw improved performance in both tSNR and functional acquisitions from pTx-EPI. Thus, we believe that online calculation pTx-EPI is robust enough for future fMRI studies, especially where activation is expected in brain areas liable to significant signal dropout." @default.
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• W4285808110 date "2022-11-01" @default.
• W4285808110 modified "2023-09-25" @default.
• W4285808110 title "Parallel transmit (pTx) with online pulse design for task-based fMRI at 7 T" @default.
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• W4285808110 doi "https://doi.org/10.1016/j.mri.2022.07.003" @default.
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