FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285809715> ?p ?o ?g. }

• W4285809715 endingPage "103109" @default.
• W4285809715 startingPage "103109" @default.
• W4285809715 abstract "Myelin water imaging is a magnetic resonance imaging (MRI) technique that quantifies myelin damage and repair in multiple sclerosis (MS) via the myelin water fraction (MWF).In this substudy of a phase 3 therapeutic trial, OPERA II, MWF was assessed in relapsing MS participants assigned to interferon beta-1a (IFNb-1a) or ocrelizumab (OCR) during a two-year double-blind period (DBP) followed by a two-year open label extension (OLE) with ocrelizumab treatment.MWF in normal appearing white matter (NAWM), including both whole brain NAWM and 5 white matter structures, and chronic lesions, was assessed in 29 OCR and 26 IFNb-1a treated participants at weeks 0, 24, 48 and 96 (DBP), and weeks 144 and 192 (OLE), and in white matter for 23 healthy control participants at weeks 0, 48 and 96.Linear mixed-effects models of data from baseline to week 96 showed a difference in the change in MWF over time favouring ocrelizumab in all NAWM regions. At week 192, lesion MWF was lower for participants originally randomised to IFNb-1a compared to those originally randomised to OCR. Controls showed no change in MWF over 96 weeks in any region.Ocrelizumab appears to protect against demyelination in MS NAWM and chronic lesions and may allow for a more permissive micro environment for remyelination to occur in focal and diffusely damaged tissue." @default.
• W4285809715 created "2022-07-19" @default.
• W4285809715 creator A5001048945 @default.
• W4285809715 creator A5004025365 @default.
• W4285809715 creator A5012087557 @default.
• W4285809715 creator A5021896055 @default.
• W4285809715 creator A5029466688 @default.
• W4285809715 creator A5030980805 @default.
• W4285809715 creator A5033042644 @default.
• W4285809715 creator A5057710841 @default.
• W4285809715 creator A5060171390 @default.
• W4285809715 creator A5071619668 @default.
• W4285809715 creator A5081310170 @default.
• W4285809715 creator A5084754494 @default.
• W4285809715 date "2022-01-01" @default.
• W4285809715 modified "2023-10-07" @default.
• W4285809715 title "Myelin water imaging in relapsing multiple sclerosis treated with ocrelizumab and interferon beta-1a" @default.
• W4285809715 cites W1595872863 @default.
• W4285809715 cites W1942882964 @default.
• W4285809715 cites W1961889966 @default.
• W4285809715 cites W1968388072 @default.
• W4285809715 cites W1981679538 @default.
• W4285809715 cites W1991509815 @default.
• W4285809715 cites W1993501415 @default.
• W4285809715 cites W2009837079 @default.
• W4285809715 cites W2027102257 @default.
• W4285809715 cites W2036559773 @default.
• W4285809715 cites W2044439746 @default.
• W4285809715 cites W2080737598 @default.
• W4285809715 cites W2090719688 @default.
• W4285809715 cites W2101539564 @default.
• W4285809715 cites W2117245594 @default.
• W4285809715 cites W2118692366 @default.
• W4285809715 cites W2136145485 @default.
• W4285809715 cites W2136573752 @default.
• W4285809715 cites W2191834907 @default.
• W4285809715 cites W2293040502 @default.
• W4285809715 cites W2404056086 @default.
• W4285809715 cites W2488956337 @default.
• W4285809715 cites W2530170980 @default.
• W4285809715 cites W2555529900 @default.
• W4285809715 cites W2556951263 @default.
• W4285809715 cites W2561881161 @default.
• W4285809715 cites W2744553073 @default.
• W4285809715 cites W2801723726 @default.
• W4285809715 cites W2900990031 @default.
• W4285809715 cites W2909629350 @default.
• W4285809715 cites W2917694209 @default.
• W4285809715 cites W3037799124 @default.
• W4285809715 cites W3045030255 @default.
• W4285809715 cites W3080676737 @default.
• W4285809715 cites W3093955191 @default.
• W4285809715 cites W3120261134 @default.
• W4285809715 cites W3121557208 @default.
• W4285809715 cites W3126596385 @default.
• W4285809715 cites W3183720253 @default.
• W4285809715 doi "https://doi.org/10.1016/j.nicl.2022.103109" @default.
• W4285809715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35878575" @default.
• W4285809715 hasPublicationYear "2022" @default.
• W4285809715 type Work @default.
• W4285809715 citedByCount "4" @default.
• W4285809715 countsByYear W42858097152022 @default.
• W4285809715 countsByYear W42858097152023 @default.
• W4285809715 crossrefType "journal-article" @default.
• W4285809715 hasAuthorship W4285809715A5001048945 @default.
• W4285809715 hasAuthorship W4285809715A5004025365 @default.
• W4285809715 hasAuthorship W4285809715A5012087557 @default.
• W4285809715 hasAuthorship W4285809715A5021896055 @default.
• W4285809715 hasAuthorship W4285809715A5029466688 @default.
• W4285809715 hasAuthorship W4285809715A5030980805 @default.
• W4285809715 hasAuthorship W4285809715A5033042644 @default.
• W4285809715 hasAuthorship W4285809715A5057710841 @default.
• W4285809715 hasAuthorship W4285809715A5060171390 @default.
• W4285809715 hasAuthorship W4285809715A5071619668 @default.
• W4285809715 hasAuthorship W4285809715A5081310170 @default.
• W4285809715 hasAuthorship W4285809715A5084754494 @default.
• W4285809715 hasBestOaLocation W42858097151 @default.
• W4285809715 hasConcept C126322002 @default.
• W4285809715 hasConcept C126838900 @default.
• W4285809715 hasConcept C142724271 @default.
• W4285809715 hasConcept C143409427 @default.
• W4285809715 hasConcept C203014093 @default.
• W4285809715 hasConcept C2778609137 @default.
• W4285809715 hasConcept C2778843634 @default.
• W4285809715 hasConcept C2779338263 @default.
• W4285809715 hasConcept C2780640218 @default.
• W4285809715 hasConcept C2780653079 @default.
• W4285809715 hasConcept C2781192897 @default.
• W4285809715 hasConcept C2989005 @default.
• W4285809715 hasConcept C529278444 @default.
• W4285809715 hasConcept C71924100 @default.
• W4285809715 hasConceptScore W4285809715C126322002 @default.
• W4285809715 hasConceptScore W4285809715C126838900 @default.
• W4285809715 hasConceptScore W4285809715C142724271 @default.
• W4285809715 hasConceptScore W4285809715C143409427 @default.
• W4285809715 hasConceptScore W4285809715C203014093 @default.
• W4285809715 hasConceptScore W4285809715C2778609137 @default.
• W4285809715 hasConceptScore W4285809715C2778843634 @default.

• next