Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285987586> ?p ?o ?g. }
- W4285987586 abstract "Abnormal accumulation of β-amyloid (Aβ) peptides is a culprit in Alzheimer's disease (AD); blocking Aβ generation is therefore being explored as a logical approach for AD treatment. Here, we demonstrate that targeted inhibition of β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE-1) in microglia has unique advantages. When Bace-1 was deleted in Alzheimer's 5xFAD microglia, fewer amyloid plaques developed, and this reduction was not due to changes in APP processing but rather to enhanced Aβ clearance, in line with the increase in a microglial gene signature favoring phagocytosis. Moreover, deletion of Bace-1 in microglia enhances functions of autophagolysosomes and Aβ-induced metabolic reprogramming necessary for Aβ degradation by favoring phosphorylation of mammalian target of rapamycin complex (mTOR) at Ser2448 and modulating the PI3K-mTOR-HIF-1α signaling pathways. Mice with deletion of Bace-1 in microglia showed no reduction in long-term potentiation, unlike global deletion of Bace-1. Our results suggest that targeted inhibition of BACE-1 in microglia is a superior strategy for AD treatment." @default.
- W4285987586 created "2022-07-20" @default.
- W4285987586 creator A5011709431 @default.
- W4285987586 creator A5038360689 @default.
- W4285987586 creator A5044271800 @default.
- W4285987586 creator A5069467385 @default.
- W4285987586 creator A5080251857 @default.
- W4285987586 date "2022-07-22" @default.
- W4285987586 modified "2023-10-18" @default.
- W4285987586 title "Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance" @default.
- W4285987586 cites W1523933087 @default.
- W4285987586 cites W1862417723 @default.
- W4285987586 cites W2026592619 @default.
- W4285987586 cites W2033067082 @default.
- W4285987586 cites W2053043919 @default.
- W4285987586 cites W2069248995 @default.
- W4285987586 cites W2124490243 @default.
- W4285987586 cites W2128613449 @default.
- W4285987586 cites W2132087224 @default.
- W4285987586 cites W2170644095 @default.
- W4285987586 cites W2548224030 @default.
- W4285987586 cites W2592518050 @default.
- W4285987586 cites W2622807556 @default.
- W4285987586 cites W2761726094 @default.
- W4285987586 cites W2787171652 @default.
- W4285987586 cites W2791832923 @default.
- W4285987586 cites W2793170415 @default.
- W4285987586 cites W2798054687 @default.
- W4285987586 cites W2801000404 @default.
- W4285987586 cites W2810355541 @default.
- W4285987586 cites W2892210142 @default.
- W4285987586 cites W2913836969 @default.
- W4285987586 cites W2918491861 @default.
- W4285987586 cites W2918727416 @default.
- W4285987586 cites W2921691737 @default.
- W4285987586 cites W2937097483 @default.
- W4285987586 cites W2954390789 @default.
- W4285987586 cites W2976163884 @default.
- W4285987586 cites W2982501787 @default.
- W4285987586 cites W2989656389 @default.
- W4285987586 cites W2997706401 @default.
- W4285987586 cites W3012807323 @default.
- W4285987586 cites W3027232257 @default.
- W4285987586 cites W3081139002 @default.
- W4285987586 cites W3091919022 @default.
- W4285987586 cites W3092929739 @default.
- W4285987586 cites W3107979799 @default.
- W4285987586 cites W3175929234 @default.
- W4285987586 cites W4283029637 @default.
- W4285987586 doi "https://doi.org/10.1126/sciadv.abo3610" @default.
- W4285987586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35857844" @default.
- W4285987586 hasPublicationYear "2022" @default.
- W4285987586 type Work @default.
- W4285987586 citedByCount "15" @default.
- W4285987586 countsByYear W42859875862022 @default.
- W4285987586 countsByYear W42859875862023 @default.
- W4285987586 crossrefType "journal-article" @default.
- W4285987586 hasAuthorship W4285987586A5011709431 @default.
- W4285987586 hasAuthorship W4285987586A5038360689 @default.
- W4285987586 hasAuthorship W4285987586A5044271800 @default.
- W4285987586 hasAuthorship W4285987586A5069467385 @default.
- W4285987586 hasAuthorship W4285987586A5080251857 @default.
- W4285987586 hasBestOaLocation W42859875862 @default.
- W4285987586 hasConcept C104317684 @default.
- W4285987586 hasConcept C126322002 @default.
- W4285987586 hasConcept C169760540 @default.
- W4285987586 hasConcept C170493617 @default.
- W4285987586 hasConcept C179104552 @default.
- W4285987586 hasConcept C185592680 @default.
- W4285987586 hasConcept C203014093 @default.
- W4285987586 hasConcept C25274449 @default.
- W4285987586 hasConcept C2776914184 @default.
- W4285987586 hasConcept C2777633098 @default.
- W4285987586 hasConcept C2779134260 @default.
- W4285987586 hasConcept C2779830541 @default.
- W4285987586 hasConcept C31705614 @default.
- W4285987586 hasConcept C502032728 @default.
- W4285987586 hasConcept C55493867 @default.
- W4285987586 hasConcept C62478195 @default.
- W4285987586 hasConcept C71924100 @default.
- W4285987586 hasConcept C77255625 @default.
- W4285987586 hasConcept C86554907 @default.
- W4285987586 hasConcept C86803240 @default.
- W4285987586 hasConcept C95444343 @default.
- W4285987586 hasConceptScore W4285987586C104317684 @default.
- W4285987586 hasConceptScore W4285987586C126322002 @default.
- W4285987586 hasConceptScore W4285987586C169760540 @default.
- W4285987586 hasConceptScore W4285987586C170493617 @default.
- W4285987586 hasConceptScore W4285987586C179104552 @default.
- W4285987586 hasConceptScore W4285987586C185592680 @default.
- W4285987586 hasConceptScore W4285987586C203014093 @default.
- W4285987586 hasConceptScore W4285987586C25274449 @default.
- W4285987586 hasConceptScore W4285987586C2776914184 @default.
- W4285987586 hasConceptScore W4285987586C2777633098 @default.
- W4285987586 hasConceptScore W4285987586C2779134260 @default.
- W4285987586 hasConceptScore W4285987586C2779830541 @default.
- W4285987586 hasConceptScore W4285987586C31705614 @default.
- W4285987586 hasConceptScore W4285987586C502032728 @default.
- W4285987586 hasConceptScore W4285987586C55493867 @default.
- W4285987586 hasConceptScore W4285987586C62478195 @default.