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- W4285992242 abstract "A common clinical dilemma is distinguishing maculopapular exanthem (MPE) with systemic symptoms from severe cutaneous drug reactions, such as drug-induced hypersensitivity syndrome (DIHS). Drug-induced acute interstitial nephritis (DI-AIN) with MPE can be especially challenging to differentiate from DIHS with renal involvement. It is crucial to distinguish DI-AIN from DIHS as the prognosis and treatment differ. Our goal was to estimate the percentage of published DI-AIN cases meeting RegiSCAR criteria for DIHS and characterize the outcomes. We conducted a systematic literature search in MEDLINE (1946-2020) to find studies of DI-AIN with MPE, including DI-AIN with DIHS. Two data collectors performed independent review and data abstraction, including age, sex, RegiSCAR criteria, mortality, and drug culprit. Thirty-seven studies with 43 cases met the selection criteria. Of 28 published DI-AIN cases, 35.7% met RegiSCAR criteria for possible DIHS and 7.1% for probable/definite DIHS. Among these cases, mortality was 23.1% (possible) and 21.4% (probable/definite), respectively, compared to 6.25% for cases not meeting DIHS criteria. This review highlights that many DI-AIN cases meet RegiSCAR criteria for possible DIHS. A DIHS diagnosis may have been missed in some cases due to the diagnostic overlap between these conditions. Since there was a trend toward higher mortality in DI-AIN cases that met RegiSCAR criteria for possible DIHS, research is needed to clarify whether these cases are DIHS and whether treatment with oral corticosteroids improves outcomes." @default.
- W4285992242 created "2022-07-21" @default.
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- W4285992242 date "2022-08-01" @default.
- W4285992242 modified "2023-09-26" @default.
- W4285992242 title "159 Diagnostic overlap of drug-induced acute interstitial nephritis with cutaneous involvement and drug-induced hypersensitivity syndrome" @default.
- W4285992242 doi "https://doi.org/10.1016/j.jid.2022.05.166" @default.
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