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- W4285992302 abstract "Risk factors for cutaneous melanoma (CM) and nonmelanoma skin cancer (NMSC) include fair skin and extensive sun exposure. But, incidence has risen despite efforts to promote sun protection. Thus, identifying methods for therapeutic prevention is needed. Antioxidants such as vitamin E are theorized to reduce cancer risk by scavenging reactive species to reduce oxidative stress and DNA damage, but associations between vitamin E intake and skin cancer risk in women remain unclear. To investigate this, we used data from >93,000 postmenopausal women from the observational arm of the Women’s Health Initiative (WHI). The final cohort comprised of 78,881 White women across the US. WHI surveys captured baseline demographics, daily dietary vitamin E estimated from food frequency questionnaires, daily supplemental vitamin E, medical history, childhood and current sun exposure, and tendency to burn or tan. Outcomes were a confirmed diagnosis of melanoma in situ or invasive CM or a self-reported diagnosis of NMSC during study follow-up. The exposure was daily dietary and supplemental vitamin E intake at baseline stratified by tertile. Hazard ratios (HR) of CM by tertile of vitamin intake were estimated by proportional hazards models as the WHI recorded time-to-diagnosis for CM. Odds ratios (OR) of NMSC by tertile of vitamin intake were assessed by logistic regressions. Overall, 1,530 CM and 13,773 NMSC cases were identified over a median 19.3 years of follow-up. No associations between vitamin E intake and CM or NMSC were observed (CM: 2nd tertile HR=1, p=0.5; 3rd tertile HR=1, p=0.5. NMSC: 2nd tertile OR=1, p=0.9; 3rd tertile OR=1, p=0.2, versus the lowest tertile of intake). In summary, total vitamin E intake did not have a protective effect against NMSC or CM risk in postmenopausal women. Further study of potential therapeutic prevention agents for skin cancer in women is needed." @default.
- W4285992302 created "2022-07-21" @default.
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- W4285992302 date "2022-08-01" @default.
- W4285992302 modified "2023-09-28" @default.
- W4285992302 title "190 Lack of association between dietary and supplemental vitamin E intake with skin cancer risk in postmenopausal women" @default.
- W4285992302 doi "https://doi.org/10.1016/j.jid.2022.05.197" @default.
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