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- W4285992421 abstract "Currently, retinoids are the first-line noninvasive treatment for decreasing the appearance of fine lines and wrinkles. Although retinol does decrease signs of photodamage and aging, it has a side effect profile of erythema, peeling, pruritus, dryness and burning and/or stinging. Bakuchiol is a natural retinol alternative with anti-aging properties and less side effects. It is a meroterpene phenol found in the seeds and leaves of the plant Psoralea coryfolia and has anti-inflammatory, antiproliferative, and antiacne properties. We assessed the efficacy and side-effect profile of bakuchiol in decreasing the appearance of fine lines and wrinkles, erythema and pigmentation. Thirty four participants were asked to apply a sunscreen with SPF 30 containing bakuchiol twice daily. A facial photograph and analytical system captured photos of the subjects’ faces at 0,4,8 and 12 weeks and a board certified dermatologist graded the facial erythema. After 12 weeks of use, bakuchiol containing sunscreen significantly reduced the surface area of subsurface spots (p=0.04), especially spots less than 2 mm2 (p<0.001) and between 2-4 mm2 (p=0.002). The spot count also significantly decreased (p<0.001). Grading done by a board-certified dermatologist revealed decreased erythema in the subjects (p<0.001). Our study demonstrates that bakuchiol containing sunscreen may decrease facial pigmentation and facial erythema." @default.
- W4285992421 created "2022-07-21" @default.
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- W4285992421 date "2022-08-01" @default.
- W4285992421 modified "2023-09-28" @default.
- W4285992421 title "LB954 Assessment of a topical bakuchiol containing cream for facial photoaging" @default.
- W4285992421 doi "https://doi.org/10.1016/j.jid.2022.05.973" @default.
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