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- W4285992444 abstract "Atopic dermatitis (AD) and bullous pemphigoid (BP) are inflammatory skin diseases associated with intense pruritus and significant quality of life (QOL) impact. While they differ in classical presentation (eczematous eruption vs urticaria and blisters) and population characteristics (young-to middle-aged persons vs elderly), early stages of BP can appear similar to AD clinically and histologically. As part of this observational cohort study, we investigated whether there were differences in anxiety and depression between the cohorts at baseline and over time. This study included 93 patients with either AD (50) or BP (43) and a history of chronic pruritus. Our cohort was mostly female (61%), mean ages 47.2 (AD) and 72.2 (BP), with mean severity scores 35.9 (AD, SCORAD) and 19.1 (BP, BPDAI). The Hospital Anxiety and Depression Scale was used to measure depression (HADS-D) and anxiety (HADS-A). At baseline, BP patients had overall higher HADS-D scores, 6.14 ± 4.4 compared to AD 4.33 ± 4.4 (p = 0.023) indicating greater depressive symptoms, although the mean HADS-D and HADS-A scores in both cohorts were in the “Normal” range (score ≤7). Notably, 31% of BP and 16% of AD patients were in the “Borderline/Abnormal” range for depression and 38% of BP and 30% of AD patients for anxiety. While HADS-D scores were noted to be increased in BP patients at baseline, no differences were found at follow-up visits in AD or BP. There were no significant changes in HADS scores over time within each cohort. Both HADS-D (PCC 0.424, p<0.01) and HADS-A (PCC 0.235, p=0.038) scores significantly correlated with itch severity measured using the ItchyQuant. Anxiety and depression are important aspects of patient care to consider in diseases such as AD and BP that can greatly impact QOL. Clinicians should be particularly mindful of depression and anxiety as it relates to itch severity." @default.
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- W4285992444 date "2022-08-01" @default.
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- W4285992444 title "268 Depression and anxiety in atopic dermatitis vs bullous pemphigoid" @default.
- W4285992444 doi "https://doi.org/10.1016/j.jid.2022.05.275" @default.
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