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• W4285992612 abstract "Necrobiosis lipoidica (NL) is a chronic granulomatous disease of the skin. A growing body of literature suggest that janus kinase (JAK) inhibitors for may be effective in the treatment of granulomatous skin diseases, including NL. Prior translational research identified activation of JAK-STAT pathways by interferon gamma (IFNγ) and other cytokines is integral to macrophage activation in these diseases. We aimed to evaluate the safety and efficacy of topical ruxolitinib, a JAK-1/2 inhibitor, for the treatment of NL. An open-label, single-arm study of 12 patients was conducted at Mayo Clinic Arizona (NCT04492618). The primary endpoint was the change in NL score (0-12) of the index treatment lesions (weeks 0 and 12). Additional endpoints included: Physician Global Assessment (PGA), body surface area (BSA), lesion count, Skindex-16, Pruritus NRS. Mean NL lesion score decreased from 4.4 (SD 1.5) at baseline to 1.7 (SD 1.0) at week 12 (P=0.003). Nine (81.8%) of patients were responsive by PGA at week 12. Mean BSA involvement decreased by 0.4% (SD 0.8, P=0.034). Mean Skindex-16 score improved from 33.8 (SD 19.4) at baseline to 11.8 (SD 13.2) at week 12 (P=0.03). There was no significant change in lesion count or pruritus NRS from baseline to week 12. This study shows that topical ruxolitinib may be an effective treatment for NL. Larger randomized controlled trials are needed to better characterize effectiveness and long-term safety of topical ruxolitinib for the treatment of NL." @default.
• W4285992612 created "2022-07-21" @default.
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• W4285992612 date "2022-08-01" @default.
• W4285992612 modified "2023-10-01" @default.
• W4285992612 title "LB947 An open-label study of topical ruxolitinib in necrobiosis lipoidica" @default.
• W4285992612 doi "https://doi.org/10.1016/j.jid.2022.05.966" @default.
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