Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286002112> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4286002112 abstract "Abstract Backgrounds : Epigenetic influence plays a role in the association between exposure to air pollution and attention deficit hyperactivity disorder (ADHD); however, research regarding sulfur dioxide (SO 2 ) is scarce. Herein, we investigate the associations between prenatal SO 2 exposure and ADHD rating scale (ARS) scores at ages 4, 6, and 8 years repeatedly in a mother-child cohort (n = 329). Whole blood samples were obtained at ages 2 and 6 years, and genome-wide DNA methylation (DNAm) was analyzed for 51 children using the Illumina Infinium HumanMethylation BeadChip. We analyzed the associations between prenatal SO 2 exposure and DNAm levels at ages 2 and 6, and investigated the association between the DNAm levels at the significant CpGs and ARS at ages 4, 6, and 8. Weighted gene co-methylation network analysis was conducted to detect modules weighted for prenatal SO 2 exposure and ARS. Results Prenatal SO 2 exposure was associated with ADHD symptoms. DNAm levels at the 6 CpGs (cg07583420 ( INS-IGF2 ), cg05075097 ( INS-IGF2 ), cg25163476 ( INS-IGF2 ), cg20296524 ( TARBP1 ), cg15705054 ( PBXIP1 ), and cg05951817 ( SLC6A4 )) at age 2 were associated with prenatal SO 2 exposure levels; however, DNAm at age 6 was not associated with prenatal SO 2 exposure. Of the 6 CpGs, 5 were grouped into a module correlated with prenatal SO 2 exposure and ARS, of which cg07583420 ( INS-IGF2 ) was persistently linked with ARS at ages 4, 6, and 8. Conclusions Changes in DNAm levels associated with prenatal SO 2 exposure during early childhood are linked to increases in ARS in later childhood." @default.
- W4286002112 created "2022-07-21" @default.
- W4286002112 creator A5012527971 @default.
- W4286002112 creator A5021384385 @default.
- W4286002112 creator A5029182095 @default.
- W4286002112 creator A5032190014 @default.
- W4286002112 creator A5033003246 @default.
- W4286002112 creator A5039800887 @default.
- W4286002112 creator A5040855454 @default.
- W4286002112 creator A5042083758 @default.
- W4286002112 creator A5058166237 @default.
- W4286002112 creator A5075190718 @default.
- W4286002112 creator A5076179270 @default.
- W4286002112 creator A5080823003 @default.
- W4286002112 creator A5088176190 @default.
- W4286002112 date "2022-07-20" @default.
- W4286002112 modified "2023-10-18" @default.
- W4286002112 title "DNA methylation at insulin-insulin like growth factor 2 is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms" @default.
- W4286002112 doi "https://doi.org/10.21203/rs.3.rs-1703984/v2" @default.
- W4286002112 hasPublicationYear "2022" @default.
- W4286002112 type Work @default.
- W4286002112 citedByCount "0" @default.
- W4286002112 crossrefType "posted-content" @default.
- W4286002112 hasAuthorship W4286002112A5012527971 @default.
- W4286002112 hasAuthorship W4286002112A5021384385 @default.
- W4286002112 hasAuthorship W4286002112A5029182095 @default.
- W4286002112 hasAuthorship W4286002112A5032190014 @default.
- W4286002112 hasAuthorship W4286002112A5033003246 @default.
- W4286002112 hasAuthorship W4286002112A5039800887 @default.
- W4286002112 hasAuthorship W4286002112A5040855454 @default.
- W4286002112 hasAuthorship W4286002112A5042083758 @default.
- W4286002112 hasAuthorship W4286002112A5058166237 @default.
- W4286002112 hasAuthorship W4286002112A5075190718 @default.
- W4286002112 hasAuthorship W4286002112A5076179270 @default.
- W4286002112 hasAuthorship W4286002112A5080823003 @default.
- W4286002112 hasAuthorship W4286002112A5088176190 @default.
- W4286002112 hasBestOaLocation W42860021121 @default.
- W4286002112 hasConcept C104317684 @default.
- W4286002112 hasConcept C118552586 @default.
- W4286002112 hasConcept C126322002 @default.
- W4286002112 hasConcept C150194340 @default.
- W4286002112 hasConcept C190727270 @default.
- W4286002112 hasConcept C2775921022 @default.
- W4286002112 hasConcept C2779234561 @default.
- W4286002112 hasConcept C2780783007 @default.
- W4286002112 hasConcept C3018923374 @default.
- W4286002112 hasConcept C33288867 @default.
- W4286002112 hasConcept C41091548 @default.
- W4286002112 hasConcept C42407357 @default.
- W4286002112 hasConcept C46973012 @default.
- W4286002112 hasConcept C54355233 @default.
- W4286002112 hasConcept C71924100 @default.
- W4286002112 hasConcept C72563966 @default.
- W4286002112 hasConcept C86803240 @default.
- W4286002112 hasConceptScore W4286002112C104317684 @default.
- W4286002112 hasConceptScore W4286002112C118552586 @default.
- W4286002112 hasConceptScore W4286002112C126322002 @default.
- W4286002112 hasConceptScore W4286002112C150194340 @default.
- W4286002112 hasConceptScore W4286002112C190727270 @default.
- W4286002112 hasConceptScore W4286002112C2775921022 @default.
- W4286002112 hasConceptScore W4286002112C2779234561 @default.
- W4286002112 hasConceptScore W4286002112C2780783007 @default.
- W4286002112 hasConceptScore W4286002112C3018923374 @default.
- W4286002112 hasConceptScore W4286002112C33288867 @default.
- W4286002112 hasConceptScore W4286002112C41091548 @default.
- W4286002112 hasConceptScore W4286002112C42407357 @default.
- W4286002112 hasConceptScore W4286002112C46973012 @default.
- W4286002112 hasConceptScore W4286002112C54355233 @default.
- W4286002112 hasConceptScore W4286002112C71924100 @default.
- W4286002112 hasConceptScore W4286002112C72563966 @default.
- W4286002112 hasConceptScore W4286002112C86803240 @default.
- W4286002112 hasLocation W42860021121 @default.
- W4286002112 hasOpenAccess W4286002112 @default.
- W4286002112 hasPrimaryLocation W42860021121 @default.
- W4286002112 hasRelatedWork W1998349112 @default.
- W4286002112 hasRelatedWork W2024490794 @default.
- W4286002112 hasRelatedWork W2046964473 @default.
- W4286002112 hasRelatedWork W2052355316 @default.
- W4286002112 hasRelatedWork W2054863651 @default.
- W4286002112 hasRelatedWork W2107880877 @default.
- W4286002112 hasRelatedWork W2128056428 @default.
- W4286002112 hasRelatedWork W2151182744 @default.
- W4286002112 hasRelatedWork W2902329290 @default.
- W4286002112 hasRelatedWork W4291019124 @default.
- W4286002112 isParatext "false" @default.
- W4286002112 isRetracted "false" @default.
- W4286002112 workType "article" @default.