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- W4286009102 abstract "<b><i>Background:</i></b> Gitelman’s and Bartter’s syndromes (GS/BS) are rare genetic tubulopathies characterized by electrolyte imbalance and activation of the renin-angiotensin-aldosterone system (RAAS). These syndromes have intriguing biochemical and hormonal abnormalities that lead them to be protected from hypertension and cardiovascular and renal remodeling. <b><i>Summary:</i></b> In this review, we explore the biochemical/molecular mechanisms induced by the activation of the RAAS and its counterregulatory arm which is particularly activated in GS/BS patients, in the context of blood pressure regulation. In addition, we report our findings in the context of the COVID-19 pandemic where we observed GS/BS subjects being protected from infection. <b><i>Key Messages:</i></b> The intracellular pathways induced by Ang II, starting from induction of oxidative stress and vasoconstriction, are crucial for the progression toward cardiovascular-renal remodeling and might be useful targets in order to reduce/halt the progression of Ang II/oxidative stress-induced cardiovascular-renal morbidity in several diseases." @default.
- W4286009102 created "2022-07-21" @default.
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- W4286009102 date "2022-01-01" @default.
- W4286009102 modified "2023-09-26" @default.
- W4286009102 title "Gitelman’s and Bartter’s Syndromes: From Genetics to the Molecular Basis of Hypertension and More" @default.
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- W4286009102 doi "https://doi.org/10.1159/000526070" @default.
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