Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286009667> ?p ?o ?g. }
- W4286009667 abstract "SUMMARY Many leukocytes use fast and flexible amoeboid migration strategies to move autonomously throughout tissues. Here, we show that the movement of mast cells (MCs), leukocytes with important roles during allergies and anaphylaxis, fundamentally differs from this rapid adhesion-free leukocyte migration. We identify a crucial role for integrin-dependent adhesion in controlling slow MC movement, which shapes the positioning and network-like tissue distribution of this long-lived immune cell type. In contrast to other immune and non-immune cells, MCs cannot compensate for the lack of integrin function by switching to another migration mode. Single-cell RNA-sequencing revealed a special role for integrins in defining a mature MC phenotype in the periarteriolar tissue space where several stromal cell types provide an anatomical niche rich in Kit ligand, the major MC growth and survival factor. Collectively, this study highlights substrate-dependent haptokinesis as an important mechanism for MC network formation and the tissue organization of resident immune cells." @default.
- W4286009667 created "2022-07-21" @default.
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- W4286009667 date "2022-07-20" @default.
- W4286009667 modified "2023-10-01" @default.
- W4286009667 title "Slow integrin-dependent migration organizes networks of tissue-resident mast cells" @default.
- W4286009667 cites W128409938 @default.
- W4286009667 cites W1491326478 @default.
- W4286009667 cites W1502103265 @default.
- W4286009667 cites W1645519732 @default.
- W4286009667 cites W1652780616 @default.
- W4286009667 cites W1972170345 @default.
- W4286009667 cites W1981641790 @default.
- W4286009667 cites W1989571703 @default.
- W4286009667 cites W1989780564 @default.
- W4286009667 cites W1996589341 @default.
- W4286009667 cites W2000513178 @default.
- W4286009667 cites W2008177080 @default.
- W4286009667 cites W2023567051 @default.
- W4286009667 cites W2023877563 @default.
- W4286009667 cites W2025383736 @default.
- W4286009667 cites W2026632078 @default.
- W4286009667 cites W2026826762 @default.
- W4286009667 cites W2035538295 @default.
- W4286009667 cites W2035632882 @default.
- W4286009667 cites W2037010084 @default.
- W4286009667 cites W2038846887 @default.
- W4286009667 cites W2039767921 @default.
- W4286009667 cites W2041357218 @default.
- W4286009667 cites W2041474347 @default.
- W4286009667 cites W2041493859 @default.
- W4286009667 cites W2046318104 @default.
- W4286009667 cites W2047053027 @default.
- W4286009667 cites W2073290778 @default.
- W4286009667 cites W2090890518 @default.
- W4286009667 cites W2093351508 @default.
- W4286009667 cites W2100895205 @default.
- W4286009667 cites W2104135721 @default.
- W4286009667 cites W2111803487 @default.
- W4286009667 cites W2120243513 @default.
- W4286009667 cites W2122228460 @default.
- W4286009667 cites W2124379487 @default.
- W4286009667 cites W2126464081 @default.
- W4286009667 cites W2129401976 @default.
- W4286009667 cites W2130265677 @default.
- W4286009667 cites W2145420458 @default.
- W4286009667 cites W2149915978 @default.
- W4286009667 cites W2150709405 @default.
- W4286009667 cites W2152239989 @default.
- W4286009667 cites W2166791153 @default.
- W4286009667 cites W2177185177 @default.
- W4286009667 cites W2223932693 @default.
- W4286009667 cites W2258506980 @default.
- W4286009667 cites W2272711685 @default.
- W4286009667 cites W2304850680 @default.
- W4286009667 cites W2312041018 @default.
- W4286009667 cites W2337731566 @default.
- W4286009667 cites W2342688693 @default.
- W4286009667 cites W2403530540 @default.
- W4286009667 cites W2472063172 @default.
- W4286009667 cites W2520035645 @default.
- W4286009667 cites W2535016255 @default.
- W4286009667 cites W2611269800 @default.
- W4286009667 cites W2614625323 @default.
- W4286009667 cites W2767394894 @default.
- W4286009667 cites W2803906736 @default.
- W4286009667 cites W2807207064 @default.
- W4286009667 cites W2889326414 @default.
- W4286009667 cites W2897650637 @default.
- W4286009667 cites W2901606464 @default.
- W4286009667 cites W2914523197 @default.
- W4286009667 cites W2932008715 @default.
- W4286009667 cites W2940120301 @default.
- W4286009667 cites W2977346494 @default.
- W4286009667 cites W3017380720 @default.
- W4286009667 cites W3025781942 @default.
- W4286009667 cites W3096742301 @default.
- W4286009667 cites W3111809848 @default.
- W4286009667 cites W3118341807 @default.
- W4286009667 cites W3121128702 @default.
- W4286009667 cites W4200044074 @default.
- W4286009667 cites W4220923643 @default.