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- W4286009719 abstract "This study aimed to investigate the effectiveness of curcumin (CCM) against gentamicin (GEN) and sodium salicylates (NaS)-induced ototoxic effects in rats. For 15 consecutive days, seven rat groups were given 1 mL/rat physiological saline orally, 1 mL/rat olive oil orally, 50 mg/kg bwt CCM orally, 120 mg/kg bwt GEN intraperitoneally, 300 mg/kg bwt NaS intraperitoneally, CCM+GEN, or CCM+NaS. The distortion product otoacoustic emission measurements were conducted. The rats' hearing function and balance have been behaviorally assessed using auditory startle response, Preyer reflex, and beam balance scale tests. The serum lipid peroxidation and oxidative stress biomarkers have been measured. Immunohistochemical investigations of the apoptotic marker caspase-3 and the inflammatory indicator nuclear factor kappa (NF-κB) in cochlear tissues were conducted. GEN and NaS exposure resulted in deficit hearing and impaired ability to retain balance. GEN and NaS exposure significantly decreased the reduced glutathione level and catalase activity but increased malondialdehyde content. GEN and NaS exposure evoked pathological alterations in cochlear and vestibular tissues and increased caspase-3 and NF-κB immunoexpression. CCM significantly counteracted the GEN and NaS injurious effects. These outcomes concluded that CCM could be a naturally efficient therapeutic agent against GEN and NaS-associated ototoxic side effects." @default.
- W4286009719 created "2022-07-21" @default.
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- W4286009719 date "2022-07-20" @default.
- W4286009719 modified "2023-10-18" @default.
- W4286009719 title "Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats" @default.
- W4286009719 cites W1045245205 @default.
- W4286009719 cites W1581795123 @default.
- W4286009719 cites W1606526565 @default.
- W4286009719 cites W1821047717 @default.
- W4286009719 cites W1975786243 @default.
- W4286009719 cites W1976219141 @default.
- W4286009719 cites W1980244467 @default.
- W4286009719 cites W1983310681 @default.
- W4286009719 cites W1986499908 @default.
- W4286009719 cites W1992225989 @default.
- W4286009719 cites W1993054367 @default.
- W4286009719 cites W1994193544 @default.
- W4286009719 cites W1996135966 @default.
- W4286009719 cites W2003092473 @default.
- W4286009719 cites W2017786805 @default.
- W4286009719 cites W2030943241 @default.
- W4286009719 cites W2034101922 @default.
- W4286009719 cites W2035639257 @default.
- W4286009719 cites W2035778488 @default.
- W4286009719 cites W2037282849 @default.
- W4286009719 cites W2039221969 @default.
- W4286009719 cites W2048034726 @default.
- W4286009719 cites W2051512454 @default.
- W4286009719 cites W2052754106 @default.
- W4286009719 cites W2056035692 @default.
- W4286009719 cites W2060455759 @default.
- W4286009719 cites W2063497441 @default.
- W4286009719 cites W2072949164 @default.
- W4286009719 cites W2079466271 @default.
- W4286009719 cites W2083375860 @default.
- W4286009719 cites W2093341940 @default.
- W4286009719 cites W2093773915 @default.
- W4286009719 cites W2096668773 @default.
- W4286009719 cites W2098864202 @default.
- W4286009719 cites W2102635192 @default.
- W4286009719 cites W2104467900 @default.
- W4286009719 cites W2104843155 @default.
- W4286009719 cites W2129040674 @default.
- W4286009719 cites W2130253389 @default.
- W4286009719 cites W2131357228 @default.
- W4286009719 cites W2135087363 @default.
- W4286009719 cites W2141515673 @default.
- W4286009719 cites W2149067076 @default.
- W4286009719 cites W2165179199 @default.
- W4286009719 cites W2166781237 @default.
- W4286009719 cites W2168745915 @default.
- W4286009719 cites W2407297331 @default.
- W4286009719 cites W2411087675 @default.
- W4286009719 cites W2513598013 @default.
- W4286009719 cites W2520943469 @default.
- W4286009719 cites W2553801530 @default.
- W4286009719 cites W2555248667 @default.
- W4286009719 cites W2594701775 @default.
- W4286009719 cites W2623184693 @default.
- W4286009719 cites W2729588591 @default.
- W4286009719 cites W2745006122 @default.
- W4286009719 cites W2775545376 @default.
- W4286009719 cites W2805029829 @default.
- W4286009719 cites W2921976528 @default.
- W4286009719 cites W2944523362 @default.
- W4286009719 cites W2964485240 @default.
- W4286009719 cites W2966021251 @default.
- W4286009719 cites W2981382756 @default.
- W4286009719 cites W2996622361 @default.
- W4286009719 cites W3001760695 @default.
- W4286009719 cites W3005157613 @default.
- W4286009719 cites W3008118257 @default.
- W4286009719 cites W3011915645 @default.
- W4286009719 cites W3014842218 @default.
- W4286009719 cites W3023440847 @default.
- W4286009719 cites W3068735935 @default.
- W4286009719 cites W3107737723 @default.
- W4286009719 cites W3135953201 @default.
- W4286009719 cites W3152324430 @default.
- W4286009719 cites W3163463387 @default.
- W4286009719 cites W3196424958 @default.
- W4286009719 cites W4220907164 @default.
- W4286009719 cites W4238157547 @default.
- W4286009719 doi "https://doi.org/10.1007/s11356-022-21932-1" @default.
- W4286009719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35859240" @default.
- W4286009719 hasPublicationYear "2022" @default.
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