Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286110688> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4286110688 endingPage "S110" @default.
- W4286110688 startingPage "S110" @default.
- W4286110688 abstract "The GLUT1 transporter mediates glucose uptake in most tissues and is upregulated in both inflammatory and malignant skin diseases. Most melanomas overexpress both GLUT1 and GLUT3, but it is unclear whether the closely related transporters are functionally redundant. Consistent with its function in keratinocytes, GLUT1 knockdown in melanoma cells (UACC-62 and Mel-juso) inhibited glucose uptake and cell proliferation. Notably, GLUT3 knockdown did not impair glucose transport yet showed even more dramatic effects on cell proliferation and morphology. Fractionation revealed the preferential localization of GLUT1 to the plasma membrane while GLUT3 preferentially localized to endosomes. RNA-sequencing, Western blotting, and immunofluorescence revealed an essential role for GLUT3 in signal transducer and activator of transcription 3 (STAT3) activation, which has been implicated in melanoma growth and metastasis. Deletion of GLUT1 or GLUT3 in primary mouse melanocytes through Tyrosinase-cre expression confirmed a critical role for GLUT3 in STAT3 activation and non-redundant roles for GLUT1 and GLUT3 in pigmentation and melanocyte proliferation ex vivo. These studies identify unique functions for GLUT1 and GLUT3 in melanoma and melanocytes and highlight the GLUT3-STAT3 signaling axis as a potential therapeutic target in melanoma." @default.
- W4286110688 created "2022-07-21" @default.
- W4286110688 creator A5007830872 @default.
- W4286110688 creator A5017359359 @default.
- W4286110688 creator A5034177582 @default.
- W4286110688 creator A5048570128 @default.
- W4286110688 creator A5060485484 @default.
- W4286110688 creator A5067487444 @default.
- W4286110688 date "2022-08-01" @default.
- W4286110688 modified "2023-09-26" @default.
- W4286110688 title "637 Non-redundant roles for GLUT1 and GLUT3 in melanoma and primary melanocytes" @default.
- W4286110688 doi "https://doi.org/10.1016/j.jid.2022.05.648" @default.
- W4286110688 hasPublicationYear "2022" @default.
- W4286110688 type Work @default.
- W4286110688 citedByCount "0" @default.
- W4286110688 crossrefType "journal-article" @default.
- W4286110688 hasAuthorship W4286110688A5007830872 @default.
- W4286110688 hasAuthorship W4286110688A5017359359 @default.
- W4286110688 hasAuthorship W4286110688A5034177582 @default.
- W4286110688 hasAuthorship W4286110688A5048570128 @default.
- W4286110688 hasAuthorship W4286110688A5060485484 @default.
- W4286110688 hasAuthorship W4286110688A5067487444 @default.
- W4286110688 hasBestOaLocation W42861106881 @default.
- W4286110688 hasConcept C134018914 @default.
- W4286110688 hasConcept C161573976 @default.
- W4286110688 hasConcept C173396325 @default.
- W4286110688 hasConcept C185592680 @default.
- W4286110688 hasConcept C2777658100 @default.
- W4286110688 hasConcept C2777952866 @default.
- W4286110688 hasConcept C2778616655 @default.
- W4286110688 hasConcept C2778923194 @default.
- W4286110688 hasConcept C2779306644 @default.
- W4286110688 hasConcept C502942594 @default.
- W4286110688 hasConcept C54355233 @default.
- W4286110688 hasConcept C55493867 @default.
- W4286110688 hasConcept C62112901 @default.
- W4286110688 hasConcept C62478195 @default.
- W4286110688 hasConcept C81885089 @default.
- W4286110688 hasConcept C86803240 @default.
- W4286110688 hasConcept C95444343 @default.
- W4286110688 hasConceptScore W4286110688C134018914 @default.
- W4286110688 hasConceptScore W4286110688C161573976 @default.
- W4286110688 hasConceptScore W4286110688C173396325 @default.
- W4286110688 hasConceptScore W4286110688C185592680 @default.
- W4286110688 hasConceptScore W4286110688C2777658100 @default.
- W4286110688 hasConceptScore W4286110688C2777952866 @default.
- W4286110688 hasConceptScore W4286110688C2778616655 @default.
- W4286110688 hasConceptScore W4286110688C2778923194 @default.
- W4286110688 hasConceptScore W4286110688C2779306644 @default.
- W4286110688 hasConceptScore W4286110688C502942594 @default.
- W4286110688 hasConceptScore W4286110688C54355233 @default.
- W4286110688 hasConceptScore W4286110688C55493867 @default.
- W4286110688 hasConceptScore W4286110688C62112901 @default.
- W4286110688 hasConceptScore W4286110688C62478195 @default.
- W4286110688 hasConceptScore W4286110688C81885089 @default.
- W4286110688 hasConceptScore W4286110688C86803240 @default.
- W4286110688 hasConceptScore W4286110688C95444343 @default.
- W4286110688 hasIssue "8" @default.
- W4286110688 hasLocation W42861106881 @default.
- W4286110688 hasOpenAccess W4286110688 @default.
- W4286110688 hasPrimaryLocation W42861106881 @default.
- W4286110688 hasRelatedWork W181881744 @default.
- W4286110688 hasRelatedWork W1860378841 @default.
- W4286110688 hasRelatedWork W1994015196 @default.
- W4286110688 hasRelatedWork W2006525554 @default.
- W4286110688 hasRelatedWork W2039667275 @default.
- W4286110688 hasRelatedWork W2068494651 @default.
- W4286110688 hasRelatedWork W2106389476 @default.
- W4286110688 hasRelatedWork W2144693486 @default.
- W4286110688 hasRelatedWork W3049305782 @default.
- W4286110688 hasRelatedWork W4282824628 @default.
- W4286110688 hasVolume "142" @default.
- W4286110688 isParatext "false" @default.
- W4286110688 isRetracted "false" @default.
- W4286110688 workType "article" @default.