Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286110907> ?p ?o ?g. }
- W4286110907 abstract "Proteins are able to irreversibly assemble biologically active ligands from building blocks bearing complementary reactive functions due their spatial proximity, through a kinetic target-guided synthetic process (also named in situ click chemistry). Although linkages thus formed are mostly passive, some of them have shown to significantly contribute to the protein binding through for instance hydrogen bonding and stacking interactions. Biocompatible reactions and click chemistry are a formidable source of inspiration for developing such new protein-directed ligations. This study reports a proximity-induced thiol-yne synthesis of carbonic anhydrase inhibitors. Not only this example widens the arsenal of kinetic target-guided synthesis (KTGS) eligible reactions, but the obtained product displayed unsuspected photophysical properties. The corresponding vinyl sulfide linkage conjugated to a coumarin core proved to be engaged in a monodirectional Z to E photoisomerization process. Further investigations guided by theoretical calculations showed that fine-tuning of the nature of the substituents on the coumarin moiety allows to obtain a bidirectional photochemical process, thus discovering a new photoswitching moiety, displaying moreover fluorescence properties. Due to the spectral tunability of coumarin derivatives, this work should open new opportunities for the design of vinyl sulfide-based photoswitch systems with modular photophysical properties." @default.
- W4286110907 created "2022-07-21" @default.
- W4286110907 creator A5016249353 @default.
- W4286110907 creator A5017532924 @default.
- W4286110907 creator A5035995343 @default.
- W4286110907 creator A5037698489 @default.
- W4286110907 creator A5038664509 @default.
- W4286110907 creator A5064744057 @default.
- W4286110907 creator A5077706216 @default.
- W4286110907 date "2022-09-01" @default.
- W4286110907 modified "2023-10-18" @default.
- W4286110907 title "Metalloenzyme‐Mediated Thiol‐Yne Addition Towards Photoisomerizable Fluorescent Dyes" @default.
- W4286110907 cites W1870801293 @default.
- W4286110907 cites W1907450442 @default.
- W4286110907 cites W1964545163 @default.
- W4286110907 cites W1969935817 @default.
- W4286110907 cites W1972547175 @default.
- W4286110907 cites W1973449775 @default.
- W4286110907 cites W1998101425 @default.
- W4286110907 cites W1999584476 @default.
- W4286110907 cites W2004925055 @default.
- W4286110907 cites W2011393168 @default.
- W4286110907 cites W2018277210 @default.
- W4286110907 cites W2024496732 @default.
- W4286110907 cites W2039001819 @default.
- W4286110907 cites W2044575523 @default.
- W4286110907 cites W2046791391 @default.
- W4286110907 cites W2070247562 @default.
- W4286110907 cites W2078632621 @default.
- W4286110907 cites W2084412851 @default.
- W4286110907 cites W2084856161 @default.
- W4286110907 cites W2089340783 @default.
- W4286110907 cites W2090507519 @default.
- W4286110907 cites W2092478799 @default.
- W4286110907 cites W2098944322 @default.
- W4286110907 cites W2099598643 @default.
- W4286110907 cites W2113154138 @default.
- W4286110907 cites W2118865435 @default.
- W4286110907 cites W2126744416 @default.
- W4286110907 cites W2133593582 @default.
- W4286110907 cites W2140898648 @default.
- W4286110907 cites W2146910635 @default.
- W4286110907 cites W2152147380 @default.
- W4286110907 cites W2155478020 @default.
- W4286110907 cites W2167165795 @default.
- W4286110907 cites W2169702602 @default.
- W4286110907 cites W2288097186 @default.
- W4286110907 cites W2321077391 @default.
- W4286110907 cites W2326558292 @default.
- W4286110907 cites W2330760879 @default.
- W4286110907 cites W2508767729 @default.
- W4286110907 cites W2528711804 @default.
- W4286110907 cites W2565819643 @default.
- W4286110907 cites W2582322962 @default.
- W4286110907 cites W2588240447 @default.
- W4286110907 cites W2592792382 @default.
- W4286110907 cites W2618283214 @default.
- W4286110907 cites W2768088666 @default.
- W4286110907 cites W2775714759 @default.
- W4286110907 cites W2777707484 @default.
- W4286110907 cites W2786983348 @default.
- W4286110907 cites W2791495218 @default.
- W4286110907 cites W2801401091 @default.
- W4286110907 cites W2805234123 @default.
- W4286110907 cites W2806856966 @default.
- W4286110907 cites W2887585241 @default.
- W4286110907 cites W2893453068 @default.
- W4286110907 cites W2898189170 @default.
- W4286110907 cites W2899359719 @default.
- W4286110907 cites W2910647810 @default.
- W4286110907 cites W2910968223 @default.
- W4286110907 cites W2914871918 @default.
- W4286110907 cites W2924053943 @default.
- W4286110907 cites W2947357552 @default.
- W4286110907 cites W2950713969 @default.
- W4286110907 cites W2976143231 @default.
- W4286110907 cites W2996361106 @default.
- W4286110907 cites W3005362744 @default.
- W4286110907 cites W3025703987 @default.
- W4286110907 cites W3026201818 @default.
- W4286110907 cites W3036981283 @default.
- W4286110907 cites W3039594420 @default.
- W4286110907 cites W3047096572 @default.
- W4286110907 cites W3094492244 @default.
- W4286110907 cites W3109296721 @default.
- W4286110907 cites W3129351820 @default.
- W4286110907 cites W3136206766 @default.
- W4286110907 cites W3137739827 @default.
- W4286110907 cites W3138959593 @default.
- W4286110907 cites W3160789548 @default.
- W4286110907 doi "https://doi.org/10.1002/chem.202202180" @default.
- W4286110907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35861353" @default.
- W4286110907 hasPublicationYear "2022" @default.
- W4286110907 type Work @default.
- W4286110907 citedByCount "2" @default.
- W4286110907 countsByYear W42861109072023 @default.
- W4286110907 crossrefType "journal-article" @default.
- W4286110907 hasAuthorship W4286110907A5016249353 @default.
- W4286110907 hasAuthorship W4286110907A5017532924 @default.
- W4286110907 hasAuthorship W4286110907A5035995343 @default.