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- W4286111558 endingPage "1091" @default.
- W4286111558 startingPage "1091" @default.
- W4286111558 abstract "In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR-induced downstream pathways were considered from the prevalence of intrinsic disorder. Mapping of the intrinsic disorder to the HCV-TLR interactome and to the TLR-based pathways of human innate immune response to the HCV infection demonstrates that substantial levels of intrinsic disorder are characteristic for proteins involved in the regulation and execution of these innate immunity pathways and in HCV-TLR interaction. Disordered regions, being commonly enriched in sites of various posttranslational modifications, may play important functional roles by promoting protein-protein interactions and support the binding of the analyzed proteins to other partners such as nucleic acids. It seems that this system represents an important illustration of the role of intrinsic disorder in virus-host warfare." @default.
- W4286111558 created "2022-07-21" @default.
- W4286111558 creator A5027796660 @default.
- W4286111558 creator A5067599101 @default.
- W4286111558 creator A5083199032 @default.
- W4286111558 date "2022-07-21" @default.
- W4286111558 modified "2023-10-06" @default.
- W4286111558 title "Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors" @default.
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