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- W4286203498 abstract "Abstract Fexinidazole is a heterocyclic compound that constitutes the first 100% oral treatment drug for African trypanosomiasis. Its effectiveness against T. brucei encouraged the investigation of its antiparasitic potential against T. cruzi , the aetiological agent of Chagas disease. Although previous studies addressed the antitrypanosomal effects of fexinidazole, none used electron microscopy to identify the main target structures of T. brucei or T. cruzi. In this work, we used microscopy techniques to analyze the ultrastructural alterations caused by fexinidazole in different developmental stages of T. cruzi . In addition to inhibiting T. cruzi proliferation, with IC 50 of 1 µM for intracellular amastigotes, fexinidazole promoted massive disorganization of reservosomes, the detachment of the plasma membrane, unpacking of nuclear heterochromatin, mitochondrial swelling, Golgi disruption and alterations in the kinetoplast-mitochondrion complex. Together, these observations point to fexinidazole as a potential drug leader for further development of chemotherapy against Chagas disease." @default.
- W4286203498 created "2022-07-21" @default.
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- W4286203498 date "2022-07-21" @default.
- W4286203498 modified "2023-09-27" @default.
- W4286203498 title "Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi" @default.
- W4286203498 doi "https://doi.org/10.21203/rs.3.rs-1848113/v1" @default.
- W4286203498 hasPublicationYear "2022" @default.
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