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- W4286207948 abstract "Sonic hedgehog (Shh) is essential for limb development, and the mechanisms that govern the propagation and maintenance of its expression has been well studied; however, the mechanisms that govern the initiation of Shh expression are incomplete. Here we report that ETV2 initiates Shh expression by changing the chromatin status of the developmental limb enhancer, ZRS. Etv2 expression precedes Shh in limb buds, and Etv2 inactivation prevents the opening of limb chromatin, including the ZRS, resulting in an absence of Shh expression. Etv2 overexpression in limb buds causes nucleosomal displacement at the ZRS, ectopic Shh expression, and polydactyly. Areas of nucleosome displacement coincide with ETS binding site clusters. ETV2 also functions as a transcriptional activator of ZRS and is antagonized by ETV4/5 repressors. Known human polydactyl mutations introduce novel ETV2 binding sites in the ZRS, suggesting that ETV2 dosage regulates ZRS activation. These studies identify ETV2 as a pioneer transcription factor (TF) regulating the onset of Shh expression, having both a chromatin regulatory role and a transcriptional activation role." @default.
- W4286207948 created "2022-07-21" @default.
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- W4286207948 date "2022-07-21" @default.
- W4286207948 modified "2023-10-14" @default.
- W4286207948 title "Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud" @default.
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- W4286207948 cites W1977038560 @default.
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- W4286207948 cites W1993035406 @default.
- W4286207948 cites W1996353071 @default.
- W4286207948 cites W1997048827 @default.
- W4286207948 cites W1997285053 @default.
- W4286207948 cites W2002391499 @default.
- W4286207948 cites W2007827699 @default.
- W4286207948 cites W2017526981 @default.
- W4286207948 cites W2030406511 @default.
- W4286207948 cites W2035618305 @default.
- W4286207948 cites W2053073820 @default.
- W4286207948 cites W2055050547 @default.
- W4286207948 cites W2056783276 @default.
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- W4286207948 cites W2082664445 @default.
- W4286207948 cites W2090384629 @default.
- W4286207948 cites W2095696977 @default.
- W4286207948 cites W2110093634 @default.
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- W4286207948 cites W2124231777 @default.
- W4286207948 cites W2128876415 @default.
- W4286207948 cites W2132117628 @default.
- W4286207948 cites W2133557974 @default.
- W4286207948 cites W2134957137 @default.
- W4286207948 cites W2139476145 @default.
- W4286207948 cites W2141876905 @default.
- W4286207948 cites W2143777308 @default.
- W4286207948 cites W2144091055 @default.
- W4286207948 cites W2145144631 @default.
- W4286207948 cites W2151754128 @default.
- W4286207948 cites W2153145187 @default.
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- W4286207948 cites W2170551349 @default.
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- W4286207948 cites W2171808845 @default.
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- W4286207948 cites W2237430945 @default.
- W4286207948 cites W2277149073 @default.
- W4286207948 cites W2281392042 @default.
- W4286207948 cites W2282254547 @default.
- W4286207948 cites W2287778117 @default.
- W4286207948 cites W2288721051 @default.
- W4286207948 cites W2464553334 @default.
- W4286207948 cites W2536097271 @default.
- W4286207948 cites W2565065629 @default.
- W4286207948 cites W2565637885 @default.
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- W4286207948 cites W2953029843 @default.
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- W4286207948 doi "https://doi.org/10.1038/s41467-022-31848-6" @default.
- W4286207948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35864091" @default.
- W4286207948 hasPublicationYear "2022" @default.
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