FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286209076> ?p ?o ?g. }

• W4286209076 endingPage "3525" @default.
• W4286209076 startingPage "3525" @default.
• W4286209076 abstract "Lipopolysaccharide (LPS) is associated with chronic intestinal inflammation and promotes intestinal cancer progression in the gut. While the interplay between LPS and intestinal immune cells has been well-characterized, little is known about LPS and the intestinal epithelium interactions. In this study, we explored the differential effects of LPS on proliferation and the transcriptome in 3D enteroids/colonoids obtained from dogs with naturally occurring gastrointestinal (GI) diseases including inflammatory bowel disease (IBD) and intestinal mast cell tumor. The study objective was to analyze the LPS-induced modulation of signaling pathways involving the intestinal epithelia and contributing to colorectal cancer development in the context of an inflammatory (IBD) or a tumor microenvironment. While LPS incubation resulted in a pro-cancer gene expression pattern and stimulated proliferation of IBD enteroids and colonoids, downregulation of several cancer-associated genes such as Gpatch4, SLC7A1, ATP13A2, and TEX45 was also observed in tumor enteroids. Genes participating in porphyrin metabolism (CP), nucleocytoplasmic transport (EEF1A1), arachidonic acid, and glutathione metabolism (GPX1) exhibited a similar pattern of altered expression between IBD enteroids and IBD colonoids following LPS stimulation. In contrast, genes involved in anion transport, transcription and translation, apoptotic processes, and regulation of adaptive immune responses showed the opposite expression patterns between IBD enteroids and colonoids following LPS treatment. In brief, the crosstalk between LPS/TLR4 signal transduction pathway and several metabolic pathways such as primary bile acid biosynthesis and secretion, peroxisome, renin-angiotensin system, glutathione metabolism, and arachidonic acid pathways may be important in driving chronic intestinal inflammation and intestinal carcinogenesis." @default.
• W4286209076 created "2022-07-21" @default.
• W4286209076 creator A5001395805 @default.
• W4286209076 creator A5011768048 @default.
• W4286209076 creator A5028552606 @default.
• W4286209076 creator A5031092581 @default.
• W4286209076 creator A5036496208 @default.
• W4286209076 creator A5056934496 @default.
• W4286209076 creator A5062945808 @default.
• W4286209076 creator A5063529721 @default.
• W4286209076 creator A5068306424 @default.
• W4286209076 creator A5070520368 @default.
• W4286209076 creator A5080870965 @default.
• W4286209076 creator A5084387267 @default.
• W4286209076 date "2022-07-20" @default.
• W4286209076 modified "2023-10-14" @default.
• W4286209076 title "Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor" @default.
• W4286209076 cites W1485876582 @default.
• W4286209076 cites W1518351006 @default.
• W4286209076 cites W1570683131 @default.
• W4286209076 cites W1574718766 @default.
• W4286209076 cites W1894349587 @default.
• W4286209076 cites W1922836231 @default.
• W4286209076 cites W1922927471 @default.
• W4286209076 cites W1967621091 @default.
• W4286209076 cites W1968464607 @default.
• W4286209076 cites W1969193178 @default.
• W4286209076 cites W1969315310 @default.
• W4286209076 cites W1969599430 @default.
• W4286209076 cites W1971541772 @default.
• W4286209076 cites W1974208182 @default.
• W4286209076 cites W1974972293 @default.
• W4286209076 cites W1984668252 @default.
• W4286209076 cites W1986249376 @default.
• W4286209076 cites W1986791525 @default.
• W4286209076 cites W1989715383 @default.
• W4286209076 cites W1989894293 @default.
• W4286209076 cites W1994190235 @default.
• W4286209076 cites W1994389789 @default.
• W4286209076 cites W1997256300 @default.
• W4286209076 cites W1998826717 @default.
• W4286209076 cites W1999272644 @default.
• W4286209076 cites W1999448532 @default.
• W4286209076 cites W1999557815 @default.
• W4286209076 cites W1999638426 @default.
• W4286209076 cites W2003064885 @default.
• W4286209076 cites W2007584860 @default.
• W4286209076 cites W2008005259 @default.
• W4286209076 cites W2017736914 @default.
• W4286209076 cites W2019709057 @default.
• W4286209076 cites W2019709699 @default.
• W4286209076 cites W2022147094 @default.
• W4286209076 cites W2033023829 @default.
• W4286209076 cites W2034028219 @default.
• W4286209076 cites W2037186017 @default.
• W4286209076 cites W2045021854 @default.
• W4286209076 cites W2049352926 @default.
• W4286209076 cites W2050014601 @default.
• W4286209076 cites W2060544552 @default.
• W4286209076 cites W2067476349 @default.
• W4286209076 cites W2067525322 @default.
• W4286209076 cites W2069200323 @default.
• W4286209076 cites W2072246786 @default.
• W4286209076 cites W2084634649 @default.
• W4286209076 cites W2086219357 @default.
• W4286209076 cites W2088723851 @default.
• W4286209076 cites W2092346711 @default.
• W4286209076 cites W2093977679 @default.
• W4286209076 cites W2094158049 @default.
• W4286209076 cites W2099716759 @default.
• W4286209076 cites W2102677667 @default.
• W4286209076 cites W2103023611 @default.
• W4286209076 cites W2106321006 @default.
• W4286209076 cites W2109558235 @default.
• W4286209076 cites W2119990392 @default.
• W4286209076 cites W2122982861 @default.
• W4286209076 cites W2123662098 @default.
• W4286209076 cites W2124819852 @default.
• W4286209076 cites W2129499324 @default.
• W4286209076 cites W2130200307 @default.
• W4286209076 cites W2132690146 @default.
• W4286209076 cites W2134415362 @default.
• W4286209076 cites W2144272122 @default.
• W4286209076 cites W2144470409 @default.
• W4286209076 cites W2145066945 @default.
• W4286209076 cites W2148990080 @default.
• W4286209076 cites W2153583721 @default.
• W4286209076 cites W2159482845 @default.
• W4286209076 cites W2164154943 @default.
• W4286209076 cites W2165194174 @default.
• W4286209076 cites W2165762437 @default.
• W4286209076 cites W2166105333 @default.
• W4286209076 cites W2167121797 @default.
• W4286209076 cites W2167279371 @default.
• W4286209076 cites W2185731902 @default.
• W4286209076 cites W2211097356 @default.
• W4286209076 cites W2229731832 @default.
• W4286209076 cites W2256634634 @default.

• next