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• W4286209326 abstract "ABSTRACT Staphylococcus aureus is a major human pathogen, which has to cope with oxidative stress as part of the host innate immune defense under macrophage and neutrophil infections. In this study, we have investigated the role of the catalase KatA and the peroxiredoxins AhpC, Tpx, and Bcp for priming and resistance under oxidative stress in S. aureus during aerobic and microaerophilic growth. The results revealed that S. aureus is resistant to high doses of up-to 100 mM H 2 O 2 during the aerobic growth. While KatA is essential for this high aerobic H 2 O 2 resistance, the peroxiredoxin AhpC contributes to detoxification of 0.4 mM H 2 O 2 in the absence of KatA. In addition, AhpC, Tpx and Bcp were shown to be required for detoxification of cumene hydroperoxide (CHP) and regeneration of the reduced state of the bacillithiol (BSH) redox potential during recovery from CHP stress in S. aureus . The high H 2 O 2 tolerance of aerobic S. aureus cells was associated with priming by endogenous H 2 O 2 levels, which was supported by an oxidative shift of the basal level of E BSH (−291 mV) compared to that in microaerophilic cells (−310 mV). In contrast, S. aureus can be primed by sub-lethal doses of 100 µM H 2 O 2 during the microaerophilic growth to acquire an improved resistance towards the otherwise lethal triggering stimulus of 10 mM H 2 O 2 . This microaerophilic priming was dependent on increased katA transcription and elevated KatA activity, whereas aerobic control cells showed already constitutive high KatA activity. Thus, KatA is the major player contributing to the high H 2 O 2 resistance of aerobic cells and to microaerophilic H 2 O 2 priming to survive the subsequent lethal triggering doses of H 2 O 2 , allowing the adaptation of S. aureus to oxidative stress under infections in different oxygen environments." @default.
• W4286209326 created "2022-07-21" @default.
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• W4286209326 date "2022-07-20" @default.
• W4286209326 modified "2023-10-16" @default.
• W4286209326 title "The catalase contributes to microaerophilic H₂O₂ priming and the peroxiredoxins AhpC, Tpx and Bcp confer resistance to organic hydroperoxides in <i>Staphylococcus aureus</i>" @default.
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• W4286209326 doi "https://doi.org/10.1101/2022.07.19.500589" @default.
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