FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286210053> ?p ?o ?g. }

• W4286210053 abstract "Abstract Most vertebrates and invertebrates such as Drosophila melanogaster are able to move in complex environments due to their ability to integrate sensory information along with motor commands. Mechanosensory structures exist along each leg to assist in motor coordination by transmitting external cues or proprioceptive information to motor centers in the central nervous system. Nevertheless, how different mechanosensory structures engage these locomotor centers and their underlying circuits remains poorly understood. Here, we tested the role of mechanosensory structures in movement initiation by optogenetically stimulating specific classes of leg sensory structures. We found that stimulation of leg Mechanosensory Bristles (MsB) and femoral Chordotonal Organ (ChO) is sufficient to initiate forward movement in immobile animals. While the stimulation of the ChO required brain centers to induce forward movement, unexpectedly, brief stimulation of leg MsB triggered sustained cyclic motor activity dependent only on circuits within the Ventral Nerve Cord (VNC). The duration of the MsB-induced movement was dependent on the number of excited cells and specific to leg afferents, since stimulation of MsB in other segments lead to different motor outcomes. MsB-mediated movement lacked inter and intra-leg coordination, but preserved antagonistic muscle activity within joints. Our data shows that sensory stimulation can act in combination with descending commands in order to elicit a faster response to mechanical stimulation. In addition, it sheds light on the ability of specific sensory circuits to modulate motor control, including initiation of movement, presenting a new system to better understand how different levels of coordination are controlled by VNC and central brain locomotor circuits. Significance Statement Sensory feedback is critical to allow smooth and stable locomotion. Proprioceptors interact directly with pre-motor centers optimizing and sustaining coordinated movement. However, initiation of moment is considered to be triggered by higher-order centers in the brain. Here we took advantage of the genetic toolkit provided by the fruit fly Drosophila melanogaster to optogenetically activate different classes of leg sensory cells in immobile animals. We found that leg mechanosensory bristles can specifically trigger sustained leg activity independently of higher-order centers as headless flies could sustain prolonged leg movement upon mechanosensory stimulation. Moreover, while this sensory-evoked movement lacks intra- and inter-leg coordination, it still preserved basic antagonistic muscle activity. These findings suggest a parallel mechanism to trigger fast movement upon sensory stimulation. In addition, it provides a new model for movement initiation and a point–of-entry to define pre-motor circuits." @default.
• W4286210053 created "2022-07-21" @default.
• W4286210053 creator A5054158726 @default.
• W4286210053 creator A5055392718 @default.
• W4286210053 creator A5056728021 @default.
• W4286210053 creator A5061698354 @default.
• W4286210053 creator A5085156932 @default.
• W4286210053 date "2022-07-20" @default.
• W4286210053 modified "2023-10-17" @default.
• W4286210053 title "Mechanosensory stimulation triggers sustained local motor activity in<i>Drosophila melanogaster</i>" @default.
• W4286210053 cites W1815156146 @default.
• W4286210053 cites W187849060 @default.
• W4286210053 cites W1927891220 @default.
• W4286210053 cites W1959866313 @default.
• W4286210053 cites W1965058295 @default.
• W4286210053 cites W1967869064 @default.
• W4286210053 cites W1969028910 @default.
• W4286210053 cites W1974336085 @default.
• W4286210053 cites W1977217014 @default.
• W4286210053 cites W1978157456 @default.
• W4286210053 cites W1981024652 @default.
• W4286210053 cites W1983447288 @default.
• W4286210053 cites W1987070790 @default.
• W4286210053 cites W1990625624 @default.
• W4286210053 cites W2002708908 @default.
• W4286210053 cites W2005161171 @default.
• W4286210053 cites W2007209883 @default.
• W4286210053 cites W2012183578 @default.
• W4286210053 cites W2022100341 @default.
• W4286210053 cites W2023064587 @default.
• W4286210053 cites W2023716285 @default.
• W4286210053 cites W2024228301 @default.
• W4286210053 cites W2030301369 @default.
• W4286210053 cites W2037967565 @default.
• W4286210053 cites W2039348394 @default.
• W4286210053 cites W2044009218 @default.
• W4286210053 cites W2056069458 @default.
• W4286210053 cites W2057582929 @default.
• W4286210053 cites W2058289443 @default.
• W4286210053 cites W2060014417 @default.
• W4286210053 cites W2078590190 @default.
• W4286210053 cites W2078621349 @default.
• W4286210053 cites W2081057391 @default.
• W4286210053 cites W2082688468 @default.
• W4286210053 cites W2088029930 @default.
• W4286210053 cites W2089538672 @default.
• W4286210053 cites W2090373601 @default.
• W4286210053 cites W2092098765 @default.
• W4286210053 cites W2093937828 @default.
• W4286210053 cites W2094728564 @default.
• W4286210053 cites W2102033338 @default.
• W4286210053 cites W2107240021 @default.
• W4286210053 cites W2115203443 @default.
• W4286210053 cites W2121371476 @default.
• W4286210053 cites W2122002176 @default.
• W4286210053 cites W2126688443 @default.
• W4286210053 cites W2136120438 @default.
• W4286210053 cites W2136465646 @default.
• W4286210053 cites W2145384795 @default.
• W4286210053 cites W2155732403 @default.
• W4286210053 cites W2159240874 @default.
• W4286210053 cites W2169487777 @default.
• W4286210053 cites W2169705936 @default.
• W4286210053 cites W2172683042 @default.
• W4286210053 cites W2273916944 @default.
• W4286210053 cites W2338776558 @default.
• W4286210053 cites W2338894068 @default.
• W4286210053 cites W2460397890 @default.
• W4286210053 cites W2548243319 @default.
• W4286210053 cites W2605171460 @default.
• W4286210053 cites W2614463946 @default.
• W4286210053 cites W2734838926 @default.
• W4286210053 cites W2737250643 @default.
• W4286210053 cites W2766134112 @default.
• W4286210053 cites W2766255495 @default.
• W4286210053 cites W2780788446 @default.
• W4286210053 cites W2783823892 @default.
• W4286210053 cites W2809773912 @default.
• W4286210053 cites W2885496356 @default.
• W4286210053 cites W2887114371 @default.
• W4286210053 cites W2888525247 @default.
• W4286210053 cites W2951628200 @default.
• W4286210053 cites W2952077706 @default.
• W4286210053 cites W2952571917 @default.
• W4286210053 cites W2964925904 @default.
• W4286210053 cites W3016509453 @default.
• W4286210053 cites W3051574499 @default.
• W4286210053 cites W3086433860 @default.
• W4286210053 cites W3108277554 @default.
• W4286210053 cites W3108286875 @default.
• W4286210053 cites W3158300028 @default.
• W4286210053 cites W3171809193 @default.
• W4286210053 cites W3208483013 @default.
• W4286210053 cites W4205910582 @default.
• W4286210053 cites W4281996973 @default.
• W4286210053 cites W4352979289 @default.
• W4286210053 cites W64102394 @default.
• W4286210053 doi "https://doi.org/10.1101/2022.07.19.500315" @default.
• W4286210053 hasPublicationYear "2022" @default.
• W4286210053 type Work @default.

• next