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- W4286213072 abstract "Abstract Glucose and lactate play important roles for tumor growth. How to simultaneously deprive tumors of glucose and lactate is a big challenge. We have developed a cascade catalytic system (denoted as FPGLC) based on fluorinated polymer (FP) with co‐loading of glucose oxidase (GOx), lactate oxidase (LOx), and catalase (CAT). GOx and LOx deprive glucose and lactate, respectively, resulting in abundant hydrogen peroxide (H 2 O 2 ) generation. Meanwhile, CAT catalyzes H 2 O 2 into O 2 , which not only promotes catalytic reactions of GOx and LOx for consuming more glucose and lactate, but also alleviates tumor hypoxia. Benefiting from the excellent cross‐membrane and transmucosal penetration capacities of FP, FPGLC rapidly accumulated in tumors and subsequently mediated enhanced cascade catalytic therapy under the guidance of photoacoustic imaging. These results demonstrate that the dual depletion of glucose and lactate with O 2 supply is a promising strategy for efficient antitumor starvation therapy." @default.
- W4286213072 created "2022-07-21" @default.
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- W4286213072 date "2022-09-12" @default.
- W4286213072 modified "2023-10-16" @default.
- W4286213072 title "Biocatalytic Depletion of Tumorigenic Energy Sources Driven by Cascade Reactions for Efficient Antitumor Therapy" @default.
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- W4286213072 doi "https://doi.org/10.1002/anie.202204584" @default.
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