Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286238721> ?p ?o ?g. }
- W4286238721 abstract "ABSTRACT The transcription factor SOX2 is a vital regulator of stem cell activity in various developing and adult tissues. Mounting evidence has demonstrated the importance of SOX2 in regulating the induction and maintenance of stemness as well as in controlling cell proliferation, lineage decisions and differentiation. Recent studies have revealed that the ability of SOX2 to regulate these stem cell features involves its function as a pioneer factor, with the capacity to target nucleosomal DNA, modulate chromatin accessibility and prepare silent genes for subsequent activation. Moreover, although SOX2 binds to similar DNA motifs in different stem cells, its multifaceted and cell type-specific functions are reliant on context-dependent features. These cell type-specific properties include variations in partner factor availability and SOX2 protein expression levels. In this Primer, we discuss recent findings that have increased our understanding of how SOX2 executes its versatile functions as a master regulator of stem cell activities." @default.
- W4286238721 created "2022-07-21" @default.
- W4286238721 creator A5028996978 @default.
- W4286238721 creator A5054203950 @default.
- W4286238721 creator A5070520166 @default.
- W4286238721 date "2022-07-15" @default.
- W4286238721 modified "2023-10-04" @default.
- W4286238721 title "SOX2 transcription factor binding and function" @default.
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