Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286247462> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4286247462 abstract "Abstract Background Glioma is a primary malignant cancer of the most common and aggressive sort occurring in the neuroectoderm, with an extremely high incidence of morbidity, mortality, and recurrence. There are limited treatment options for glioma. It is recognized that dysregulation of RNA binding proteins (RBPs) is intimately involved in the occurrence and progression of multiple malignant cancers. However, the role of RBP in glioma is not fully understood. In the current study, we used a new model to predict the course of glioma development and prognosis related to RBP. Methods To begin with, we obtained RNA-seq profiles of glioma and matched clinical data from the Chinese Glioma Genome Data (CGGA) database. The unsupervised clustering algorithms such as the K-means clustering algorithm, t-SNE, U-MAP, and principal component analysis were used to identify tumor subtypes that were pivotal in the development of glioma. Subsequently the progression of tumor subtypes was determined by the MS scoring model and proposed time series analysis. Next, RBPs with a major role in the progression of glioma were identified by weighted gene co-expression network analysis and Lasso Cox regression models. Functional analysis of key RBP-related genes was performed by gene set enrichment analysis (GSEA) and the STRING database to reveal the potential mechanisms of the biomarker. Results A total of six tumor subgroups were identified and were strongly homogeneous among subgroups. The stages of progression of the six tumor subgroups were identified by the proposed time-series analysis and MS model. We confirmed that BCLAF1 was correlated with survival in glioma patients and was closely associated with the progression of glioma by weighted gene co-expression network analysis, Lasso Cox, and multivariate Cox regression analysis. Finally, Functional annotation shows that BCLAF1 may influence the progression of glioma through RNA shearing that affects cell cycle, Wnt signaling pathway, and other cancer development signals. Conclusions In summary, the present study first identified six subtypes of glioma progression as well as the malignancy ranking. Secondly, it was established that BCLAF1 could be used as an RBP-related prognostic marker with extremely important applications in the clinical diagnosis and personalized treatment of glioma." @default.
- W4286247462 created "2022-07-21" @default.
- W4286247462 creator A5009017304 @default.
- W4286247462 creator A5011336448 @default.
- W4286247462 creator A5021374991 @default.
- W4286247462 creator A5022746945 @default.
- W4286247462 creator A5032694786 @default.
- W4286247462 creator A5034623064 @default.
- W4286247462 creator A5039398140 @default.
- W4286247462 creator A5048794921 @default.
- W4286247462 creator A5064884940 @default.
- W4286247462 creator A5071773009 @default.
- W4286247462 creator A5079714321 @default.
- W4286247462 creator A5083217404 @default.
- W4286247462 creator A5090420512 @default.
- W4286247462 creator A5091161457 @default.
- W4286247462 date "2022-07-05" @default.
- W4286247462 modified "2023-09-23" @default.
- W4286247462 title "A novel model-based identification and validation of pivotal RNA-binding protein in the evolution of glioma" @default.
- W4286247462 doi "https://doi.org/10.21203/rs.3.rs-1778371/v1" @default.
- W4286247462 hasPublicationYear "2022" @default.
- W4286247462 type Work @default.
- W4286247462 citedByCount "0" @default.
- W4286247462 crossrefType "posted-content" @default.
- W4286247462 hasAuthorship W4286247462A5009017304 @default.
- W4286247462 hasAuthorship W4286247462A5011336448 @default.
- W4286247462 hasAuthorship W4286247462A5021374991 @default.
- W4286247462 hasAuthorship W4286247462A5022746945 @default.
- W4286247462 hasAuthorship W4286247462A5032694786 @default.
- W4286247462 hasAuthorship W4286247462A5034623064 @default.
- W4286247462 hasAuthorship W4286247462A5039398140 @default.
- W4286247462 hasAuthorship W4286247462A5048794921 @default.
- W4286247462 hasAuthorship W4286247462A5064884940 @default.
- W4286247462 hasAuthorship W4286247462A5071773009 @default.
- W4286247462 hasAuthorship W4286247462A5079714321 @default.
- W4286247462 hasAuthorship W4286247462A5083217404 @default.
- W4286247462 hasAuthorship W4286247462A5090420512 @default.
- W4286247462 hasAuthorship W4286247462A5091161457 @default.
- W4286247462 hasBestOaLocation W42862474621 @default.
- W4286247462 hasConcept C121608353 @default.
- W4286247462 hasConcept C126322002 @default.
- W4286247462 hasConcept C2778227246 @default.
- W4286247462 hasConcept C2779256057 @default.
- W4286247462 hasConcept C502942594 @default.
- W4286247462 hasConcept C50382708 @default.
- W4286247462 hasConcept C54355233 @default.
- W4286247462 hasConcept C70721500 @default.
- W4286247462 hasConcept C71924100 @default.
- W4286247462 hasConcept C86803240 @default.
- W4286247462 hasConceptScore W4286247462C121608353 @default.
- W4286247462 hasConceptScore W4286247462C126322002 @default.
- W4286247462 hasConceptScore W4286247462C2778227246 @default.
- W4286247462 hasConceptScore W4286247462C2779256057 @default.
- W4286247462 hasConceptScore W4286247462C502942594 @default.
- W4286247462 hasConceptScore W4286247462C50382708 @default.
- W4286247462 hasConceptScore W4286247462C54355233 @default.
- W4286247462 hasConceptScore W4286247462C70721500 @default.
- W4286247462 hasConceptScore W4286247462C71924100 @default.
- W4286247462 hasConceptScore W4286247462C86803240 @default.
- W4286247462 hasLocation W42862474621 @default.
- W4286247462 hasOpenAccess W4286247462 @default.
- W4286247462 hasPrimaryLocation W42862474621 @default.
- W4286247462 hasRelatedWork W1496570301 @default.
- W4286247462 hasRelatedWork W1931738192 @default.
- W4286247462 hasRelatedWork W1972028817 @default.
- W4286247462 hasRelatedWork W2001355942 @default.
- W4286247462 hasRelatedWork W2342168255 @default.
- W4286247462 hasRelatedWork W2572375357 @default.
- W4286247462 hasRelatedWork W2897072461 @default.
- W4286247462 hasRelatedWork W3025969769 @default.
- W4286247462 hasRelatedWork W3148213590 @default.
- W4286247462 hasRelatedWork W4245298553 @default.
- W4286247462 isParatext "false" @default.
- W4286247462 isRetracted "false" @default.
- W4286247462 workType "article" @default.