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- W4286252308 abstract "Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory FcγRIIB (CD32B). Dogma suggests inhibition is mediated through the FcγRIIB immunoreceptor tyrosine-based inhibition motif (ITIM), negatively regulating immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling from activating FcγR. To assess this, we generated experimental models expressing human (h)FcγRIIB on targets or effectors, lacking or retaining ITIM signaling capacity. We demonstrate that signaling through the hFcγRIIB ITIM is dispensable for impairing monoclonal antibody (mAb)-mediated depletion of normal and malignant murine target cells through three therapeutically relevant surface receptors (CD20, CD25, and OX40) affecting immunotherapy. We demonstrate that hFcγRIIB competition with activating FcγRs for antibody Fc, rather than ITIM signaling, is sufficient to impair activating FcγR engagement, inhibiting effector function and immunotherapy." @default.
- W4286252308 created "2022-07-21" @default.
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- W4286252308 date "2022-07-01" @default.
- W4286252308 modified "2023-10-01" @default.
- W4286252308 title "FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms" @default.
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- W4286252308 cites W1750939701 @default.
- W4286252308 cites W1862569453 @default.
- W4286252308 cites W1942129679 @default.
- W4286252308 cites W1966727106 @default.
- W4286252308 cites W1971242419 @default.
- W4286252308 cites W1973647796 @default.
- W4286252308 cites W1978972377 @default.
- W4286252308 cites W1986574524 @default.
- W4286252308 cites W1991535283 @default.
- W4286252308 cites W1992108947 @default.
- W4286252308 cites W1996710470 @default.
- W4286252308 cites W2000061036 @default.
- W4286252308 cites W2002496843 @default.
- W4286252308 cites W2003244776 @default.
- W4286252308 cites W2004756723 @default.
- W4286252308 cites W2009109361 @default.
- W4286252308 cites W2010310014 @default.
- W4286252308 cites W2010329820 @default.
- W4286252308 cites W2017873446 @default.
- W4286252308 cites W2018192985 @default.
- W4286252308 cites W2036995752 @default.
- W4286252308 cites W2043228552 @default.
- W4286252308 cites W2048787440 @default.
- W4286252308 cites W2052077324 @default.
- W4286252308 cites W2053313205 @default.
- W4286252308 cites W2057745345 @default.
- W4286252308 cites W2063909696 @default.
- W4286252308 cites W2067488824 @default.
- W4286252308 cites W2071875829 @default.
- W4286252308 cites W2075785757 @default.
- W4286252308 cites W2083091113 @default.
- W4286252308 cites W2083480719 @default.
- W4286252308 cites W2084039682 @default.
- W4286252308 cites W2104088439 @default.
- W4286252308 cites W2110794121 @default.
- W4286252308 cites W2110990893 @default.
- W4286252308 cites W2115450015 @default.
- W4286252308 cites W2117281169 @default.
- W4286252308 cites W2119008186 @default.
- W4286252308 cites W2128402413 @default.
- W4286252308 cites W2134057839 @default.
- W4286252308 cites W2140516324 @default.
- W4286252308 cites W2141484788 @default.
- W4286252308 cites W2147350757 @default.
- W4286252308 cites W2166874143 @default.
- W4286252308 cites W2285839050 @default.
- W4286252308 cites W2334505016 @default.
- W4286252308 cites W2380566153 @default.
- W4286252308 cites W2467602923 @default.
- W4286252308 cites W2528260904 @default.
- W4286252308 cites W2550794796 @default.
- W4286252308 cites W2607137647 @default.
- W4286252308 cites W2677663897 @default.
- W4286252308 cites W2782652020 @default.
- W4286252308 cites W2784597909 @default.
- W4286252308 cites W2901938738 @default.
- W4286252308 cites W2922709611 @default.
- W4286252308 cites W2971108270 @default.
- W4286252308 cites W3036939904 @default.
- W4286252308 cites W3080759034 @default.
- W4286252308 cites W3098454574 @default.
- W4286252308 cites W3117480333 @default.
- W4286252308 cites W3186485642 @default.
- W4286252308 cites W4205628911 @default.
- W4286252308 cites W4207044427 @default.
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- W4286252308 doi "https://doi.org/10.1016/j.celrep.2022.111099" @default.
- W4286252308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35858562" @default.
- W4286252308 hasPublicationYear "2022" @default.
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