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- W4286252713 abstract "Secretory immunoglobulin A (SIgA) interaction with commensal bacteria conditions microbiota composition and function. However, mechanisms regulating reciprocal control of microbiota and SIgA are not defined. Bacteria-derived adenosine triphosphate (ATP) limits T follicular helper (Tfh) cells in the Peyer's patches (PPs) via P2X7 receptor (P2X7R) and thereby SIgA generation. Here we show that hydrolysis of extracellular ATP (eATP) by apyrase results in amplification of the SIgA repertoire. The enhanced breadth of SIgA in mice colonized with apyrase-releasing Escherichia coli influences topographical distribution of bacteria and expression of genes involved in metabolic versus immune functions in the intestinal epithelium. SIgA-mediated conditioning of bacteria and enterocyte function is reflected by differences in nutrient absorption in mice colonized with apyrase-expressing bacteria. Apyrase-induced SIgA improves intestinal homeostasis and attenuates barrier impairment and susceptibility to infection by enteric pathogens in antibiotic-induced dysbiosis. Therefore, amplification of SIgA by apyrase can be leveraged to restore intestinal fitness in dysbiotic conditions." @default.
- W4286252713 created "2022-07-21" @default.
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- W4286252713 date "2022-07-01" @default.
- W4286252713 modified "2023-09-30" @default.
- W4286252713 title "Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis" @default.
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- W4286252713 doi "https://doi.org/10.1016/j.celrep.2022.111112" @default.
- W4286252713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35858559" @default.
- W4286252713 hasPublicationYear "2022" @default.
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