FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286255663> ?p ?o ?g. }

• W4286255663 endingPage "115567" @default.
• W4286255663 startingPage "115567" @default.
• W4286255663 abstract "Liver fibrosis is a chronic liver disease that can lead to cirrhosis, liver failure, and hepatocellular carcinoma, and it is associated with long-term adverse outcomes and mortality. As a primary resource for complementary and alternative medicine, traditional Chinese medicine (TCM) has accumulated a large number of effective formulas for the treatment of liver fibrosis in clinical practice. However, studies on how to systematically optimize TCM formulas are still lacking. To provide a methodological reference for the systematic optimization of TCM formulae against liver fibrosis and explored the underlying molecular mechanisms; To provide an efficient method for searching for lead compounds from natural sources and developing from herbal medicines; To enable clinicians and patients to make more reasonable choices and promote the effective treatment toward those patients with liver fibrosis. TCM formulas related to treating liver fibrosis were collected from the Web of Science, PubMed, the China National Knowledge Infrastructure (CNKI), Wan Fang, and the Chinese Scientific Journals Database (VIP). Furthermore, the TCM compatibility patterns were mined using association analysis. The core TCM combinations were found by designing an optimized formulas algorithm. Finally, the hub target proteins, potential molecular mechanisms, and active compounds were explored through integrative pharmacology and docking-based inverse virtual screening (IVS) approaches. We found that the herbs for reinforcing deficiency, activating blood, removing blood stasis, and clearing heat were the basis of TCM formulae patterns. Furthermore, the combination of Salviae Miltiorrhizae (Salvia miltiorrhiza Bunge; Chinese salvia/Danshen), Astragali Radix (Astragalus membranaceus (Fisch.) Bunge; Astragalus/Huangqi), and Radix Bupleuri (Bupleurum chinense DC.; Bupleurum/Chaihu) was identified as core groups. A total of six targets (TNF, STAT3, EGFR, IL2, ICAM1, PTGS2) play a pivotal role in TCM-mediated liver fibrosis inhibition. (−)-Cryptotanshinone, Tanshinaldehyde, Ononin, Thymol, Daidzein, and Formononetin were identified as active compounds in TCM. And mechanistically, TCM could affect the development of liver fibrosis by regulating inflammation, immunity, angiogenesis, antioxidants, and involvement in TNF, MicroRNAs, Jak-STAT, NF-kappa B, and C-type lectin receptors (CLRs) signaling pathways. Molecular docking results showed that key components had good potential to bind to the target genes. In summary, this study provides a methodological reference for the systematic optimization of TCM formulae and exploration of underlying molecular mechanisms." @default.
• W4286255663 created "2022-07-21" @default.
• W4286255663 creator A5009744459 @default.
• W4286255663 creator A5015012309 @default.
• W4286255663 creator A5019645685 @default.
• W4286255663 creator A5021687717 @default.
• W4286255663 creator A5039461460 @default.
• W4286255663 creator A5050382136 @default.
• W4286255663 creator A5057949766 @default.
• W4286255663 creator A5071541212 @default.
• W4286255663 creator A5088096061 @default.
• W4286255663 date "2022-10-01" @default.
• W4286255663 modified "2023-10-15" @default.
• W4286255663 title "An optimized herbal combination for the treatment of liver fibrosis: Hub genes, bioactive ingredients, and molecular mechanisms" @default.
• W4286255663 cites W1544009106 @default.
• W4286255663 cites W1774228708 @default.
• W4286255663 cites W1854632697 @default.
• W4286255663 cites W1906327883 @default.
• W4286255663 cites W1973710869 @default.
• W4286255663 cites W1976777085 @default.
• W4286255663 cites W1997362383 @default.
• W4286255663 cites W2015284016 @default.
• W4286255663 cites W2020084080 @default.
• W4286255663 cites W2023044058 @default.
• W4286255663 cites W2024790024 @default.
• W4286255663 cites W2035673396 @default.
• W4286255663 cites W2042570069 @default.
• W4286255663 cites W2042938039 @default.
• W4286255663 cites W2049938006 @default.
• W4286255663 cites W2056782561 @default.
• W4286255663 cites W2061161895 @default.
• W4286255663 cites W2062952133 @default.
• W4286255663 cites W2069849035 @default.
• W4286255663 cites W2078668520 @default.
• W4286255663 cites W2091096046 @default.
• W4286255663 cites W2123500593 @default.
• W4286255663 cites W2136850043 @default.
• W4286255663 cites W2139202210 @default.
• W4286255663 cites W2220594341 @default.
• W4286255663 cites W2336040088 @default.
• W4286255663 cites W2343503409 @default.
• W4286255663 cites W2396930286 @default.
• W4286255663 cites W2411666094 @default.
• W4286255663 cites W2469102333 @default.
• W4286255663 cites W2518987390 @default.
• W4286255663 cites W2552083010 @default.
• W4286255663 cites W2565588562 @default.
• W4286255663 cites W2587805291 @default.
• W4286255663 cites W2588176311 @default.
• W4286255663 cites W2607229053 @default.
• W4286255663 cites W2607326270 @default.
• W4286255663 cites W2612145762 @default.
• W4286255663 cites W2624797255 @default.
• W4286255663 cites W2728683192 @default.
• W4286255663 cites W2741309469 @default.
• W4286255663 cites W2761687106 @default.
• W4286255663 cites W2765805888 @default.
• W4286255663 cites W2769223366 @default.
• W4286255663 cites W2776484474 @default.
• W4286255663 cites W2785091318 @default.
• W4286255663 cites W2790962805 @default.
• W4286255663 cites W2796699845 @default.
• W4286255663 cites W2799452674 @default.
• W4286255663 cites W2799974540 @default.
• W4286255663 cites W2800351476 @default.
• W4286255663 cites W2801088198 @default.
• W4286255663 cites W2807620615 @default.
• W4286255663 cites W2808071690 @default.
• W4286255663 cites W2829356211 @default.
• W4286255663 cites W2844503360 @default.
• W4286255663 cites W2881438881 @default.
• W4286255663 cites W2883071546 @default.
• W4286255663 cites W2886504687 @default.
• W4286255663 cites W2888538474 @default.
• W4286255663 cites W2890158083 @default.
• W4286255663 cites W2890324251 @default.
• W4286255663 cites W2892759967 @default.
• W4286255663 cites W2893835498 @default.
• W4286255663 cites W2899830682 @default.
• W4286255663 cites W2913004193 @default.
• W4286255663 cites W2915321625 @default.
• W4286255663 cites W2921434986 @default.
• W4286255663 cites W2922229918 @default.
• W4286255663 cites W2932172543 @default.
• W4286255663 cites W2938048562 @default.
• W4286255663 cites W2941766873 @default.
• W4286255663 cites W2943048707 @default.
• W4286255663 cites W2943921906 @default.
• W4286255663 cites W2944039552 @default.
• W4286255663 cites W2945955076 @default.
• W4286255663 cites W2949225922 @default.
• W4286255663 cites W2951891435 @default.
• W4286255663 cites W2952297670 @default.
• W4286255663 cites W2954917865 @default.
• W4286255663 cites W2961328380 @default.
• W4286255663 cites W2964366186 @default.
• W4286255663 cites W2965150010 @default.
• W4286255663 cites W2965264299 @default.

• next