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- W4286264225 abstract "• Coumarin based azo compounds were synthesized by conventional diazo-coupling reaction method. • Synthesized azo dyes were thoroughly characterized by various spectroscopic techniques. • Coumarin is known as biologically active compounds and its efficiency was increased by the linkage of azo unit. • In future these prepared azo compounds were effectively employed in clinical applications. In this paper we reported the synthesis of four different heterocyclic amines was utilized and treated with 4-Methylumbelliferone coupling component in acidic medium at 0-5°C. The synthesized azo compounds were characterized by various spectroscopic techniques such as IR, ( 1 H & 13 C) NMR, UV-Visible and Mass spectrometry. Further, all the synthesized azo compounds were screened for various biological activities such as antimicrobial, anti-tuberculosis, anti-cancer, anti-inflammatory and DNA cleavage studies and results revealed that, all the compounds shown potential activity towards the tested pathogenic strains. Parameters drug-likeness and ADMET properties are calculated." @default.
- W4286264225 created "2022-07-21" @default.
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- W4286264225 date "2022-12-01" @default.
- W4286264225 modified "2023-10-16" @default.
- W4286264225 title "Synthesis, characterization and biological evaluation of heterocyclic compounds containing 4-methylumbelliferone" @default.
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- W4286264225 doi "https://doi.org/10.1016/j.molstruc.2022.133759" @default.
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